Search Results - "da Silva, Claudia L"

Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis by Carvalho, Marta S., Poundarik, Atharva A., Cabral, Joaquim M. S., da Silva, Cláudia L., Vashishth, Deepak

“…Bone regeneration, following fracture, relies on autologous and allogenic bone grafts. However, majority of fracture population consists of older individuals…”
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Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells by de Soure, António M., Fernandes-Platzgummer, Ana, da Silva, Cláudia L., Cabral, Joaquim M.S.

“…•Comprehensive overview on the manufacturing of human mesenchymal stem/stromal cells.•Bioprocess engineering approaches combining bioreactors with microcarrier…”
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Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix by Carvalho, Marta S, Cabral, Joaquim M S, da Silva, Cláudia L, Vashishth, Deepak

“…Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant importance since most of the outstanding properties of the bone…”
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A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells by dos Santos, Francisco, Campbell, Andrew, Fernandes-Platzgummer, Ana, Andrade, Pedro Z., Gimble, Jeffrey M., Wen, Yuan, Boucher, Shayne, Vemuri, Mohan C., da Silva, Cláudia L., Cabral, Joaquim M.S.

“…ABSTRACT The large cell doses (>1 × 106 cells/kg) used in clinical trials with mesenchymal stem/stromal cells (MSC) will require an efficient production…”
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Synergistic effect of extracellularly supplemented osteopontin and osteocalcin on stem cell proliferation, osteogenic differentiation, and angiogenic properties by Carvalho, Marta S, Cabral, Joaquim MS, da Silva, Cláudia L, Vashishth, Deepak

“…A high demand for functional bone grafts is being observed worldwide, especially due to the increased life expectancy. Osteoinductive components should be…”
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Extracellular matrix decorated polycaprolactone scaffolds for improved mesenchymal stem/stromal cell osteogenesis towards a patient‐tailored bone tissue engineering approach by Silva, João C., Carvalho, Marta S., Udangawa, Ranodhi N., Moura, Carla S., Cabral, Joaquim M. S., L. da Silva, Cláudia, Ferreira, Frederico Castelo, Vashishth, Deepak, Linhardt, Robert J.

“…The clinical demand for tissue‐engineered bone is growing due to the increase of non‐union fractures and delayed healing in an aging population. Herein, we…”
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Tridimensional configurations of human mesenchymal stem/stromal cells to enhance cell paracrine potential towards wound healing processes by Costa, Marta H.G., McDevitt, Todd C., Cabral, Joaquim M.S., da Silva, Cláudia L., Ferreira, Frederico Castelo

“…•Side-by-side comparison of three 3D configurations vs 2D monolayer MSC cultures.•3D MSC cultures include spheroids and alginate encapsulated spheroids or…”
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Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells by Mizukami, Amanda, Fernandes-Platzgummer, Ana, Carmelo, Joana G., Swiech, Kamilla, Covas, Dimas T., Cabral, Joaquim M. S., da Silva, Cláudia L.

“…Mesenchymal stem/stromal cells (MSC) are being widely explored as promising candidates for cell‐based therapies. Among the different human MSC origins…”
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Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage by Leite, Cristiana, Silva, N Tatiana, Mendes, Sandrine, Ribeiro, Andreia, de Faria, Joana Paes, Lourenço, Tânia, dos Santos, Francisco, Andrade, Pedro Z, Cardoso, Carla M P, Vieira, Margarida, Paiva, Artur, da Silva, Cláudia L, Cabral, Joaquim M S, Relvas, João B, Grãos, Mário

“…Mesenchymal stem cells (MSCs) are viewed as safe, readily available and promising adult stem cells, which are currently used in several clinical trials…”
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Impact of Donor Age on the Osteogenic Supportive Capacity of Mesenchymal Stromal Cell-Derived Extracellular Matrix by Carvalho, Marta S, Alves, Laura, Bogalho, Isabel, Cabral, Joaquim M S, da Silva, Cláudia L

“…Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based therapeutic option for regenerative medicine applications as these cells can…”
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Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix‐derived mesenchymal stem/stromal cells by Soure, António M., Fernandes‐Platzgummer, Ana, Moreira, Francisco, Lilaia, Carla, Liu, Shi‐Hwei, Ku, Chen‐Peng, Huang, Yi‐Feng, Milligan, William, Cabral, Joaquim M. S., Silva, Cláudia L.

“…Umbilical cord matrix (UCM)‐derived mesenchymal stem/stromal cells (MSCs) are promising therapeutic candidates for regenerative medicine settings. UCM MSCs…”
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Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomics by Madeira, Andreia, da Silva, Cláudia L, dos Santos, Francisco, Camafeita, Emilio, Cabral, Joaquim M S, Sá-Correia, Isabel

“…Human mesenchymal stem cells (MSC) have been on the focus of intense clinical-oriented research due to their multilineage differentiation potential and…”
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Bioengineered Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles as an Improved Drug Delivery System: Methods and Applications by Ulpiano, Cristiana, da Silva, Cláudia L, Monteiro, Gabriel A

“…Extracellular vesicles (EVs) are cell-derived nano-sized lipid membranous structures that modulate cell-cell communication by transporting a variety of…”
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A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells by Mizukami, Amanda, de Abreu Neto, Mario Soares, Moreira, Francisco, Fernandes-Platzgummer, Ana, Huang, Yi-Feng, Milligan, William, Cabral, Joaquim M. S., da Silva, Cláudia L., Covas, Dimas T., Swiech, Kamilla

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Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications by Branco, André, Rayabaram, Janakiram, Miranda, Cláudia C, Fernandes-Platzgummer, Ana, Fernandes, Tiago G, Sajja, Suchitra, da Silva, Cláudia L, Vemuri, Mohan C

“…As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply of differentiated populations that are responsible for critical…”
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Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids by Pinto, Catarina I. G., Branco, André D. M., Bucar, Sara, Fonseca, Alexandra, Abrunhosa, Antero J., da Silva, Cláudia L., Guerreiro, Joana F., Mendes, Filipa

“…Background Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there…”
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Enhanced Proliferative and Osteogenic Potential of Periodontal Ligament Stromal Cells by Alves, Laura, Machado, Vanessa, Botelho, João, Mendes, José João, Cabral, Joaquim M S, da Silva, Cláudia L, Carvalho, Marta S

“…Cell-based therapies using periodontal ligament stromal cells (PDLSC) for periodontal regeneration may represent an alternative source for mesenchymal stromal…”
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Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells by Bucar, Sara, Branco, André Dargen de Matos, Mata, Márcia F, Milhano, João Coutinho, Caramalho, Ãris, Cabral, Joaquim M. S, Fernandes-Platzgummer, Ana, da Silva, Cláudia L

“…Background Umbilical cord blood (UCB) is a clinically relevant alternative source of hematopoietic stem/progenitor cells (HSPC). To overcome the low cell…”
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Neurodifferentiation and neuroprotection potential of mesenchymal stromal cell-derived secretome produced in different dynamic systems by Marques, Cláudia Raquel, Fuzeta, Miguel de Almeida, Cunha, Raquel Medina dos Santos, Pereira-Sousa, Joana, Silva, Deolinda, Campos, Jonas Oliveira, Teixeira-Castro, Andreia, Sousa, Rui Pedro Romero Amandi, Fernandes-Platzgummer, Ana, Silva, Cláudia L. da, Salgado, A. J.

“…Parkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by the degeneration of the dopamine (DA) neurons in the…”
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Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept by Almeida, Afonso R, Correia, Daniel V, Fernandes-Platzgummer, Ana, da Silva, Cláudia L, da Silva, Maria Gomes, Anjos, Diogo Remechido, Silva-Santos, Bruno

“…The Vδ1 subset of γδ T lymphocytes is a promising candidate for cancer immunotherapy, but the lack of suitable expansion/differentiation methods has precluded…”
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