Anxiolytic-, antidepressant- and anticonvulsant-like effects of the alkaloid montanine isolated from Hippeastrum vittatum

Compounds isolated from different members of the Amaryllidaceae family are becoming relevant options for the treatment of neurological disorders and neurodegenerative diseases. In particular, species of the Hippeastrum genus are important source of alkaloids with a wide profile of putative therapeut...

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Bibliographic Details
Published in:	Pharmacology, biochemistry and behavior Vol. 85; no. 1; pp. 148 - 154
Main Authors:	da Silva, Ana Flávia Schürmann, de Andrade, Jean Paulo, Bevilaqua, Lia R.M., de Souza, Márcia Maria, Izquierdo, Ivan, Henriques, Amélia Teresinha, Zuanazzi, José Ângelo Silveira
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-09-2006 Elsevier Science
Subjects:	Adult and adolescent clinical studies Alkaloid Amaryllidaceae Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Antidepressive Agents - pharmacology Anxiety Behavior, Animal - drug effects Biological and medical sciences Convulsion Depression Hippeastrum Isoquinolines - isolation & purification Isoquinolines - pharmacology Liliaceae - chemistry Medical sciences Memory Mice Montanine Mood disorders Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Rats, Wistar Hippeastrum Alkaloid Convulsion Memory Depression Montanine Anxiety Amaryllidaceae Mood disorder Monocotyledones Nervous system diseases Psychotropic Anticonvulsant Chemotherapy Treatment Tranquillizer Angiospermae Antidepressant agent Spermatophyta Neurological disorder
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Summary:	Compounds isolated from different members of the Amaryllidaceae family are becoming relevant options for the treatment of neurological disorders and neurodegenerative diseases. In particular, species of the Hippeastrum genus are important source of alkaloids with a wide profile of putative therapeutical applications. Here, we report on the behavioral and pharmaco-toxicological characterization of montanine, an isoquinoline alkaloid isolated from Hippeastrum vittatum, an ornamental plant found throughout the world. In mice, montanine showed a LD 50 of 64.7 mg/kg and 67.6 mg/kg for male and female, respectively. When given i.p., montanine dose-dependently decreased sodium pentobarbital-induced sleep, protected against pentylenetetrazole-provoked convulsions, increased the number of entries and the time spent in the open arms of an elevated plus maze and augmented the time spent struggling during a forced swimming test. When given immediately after inhibitory avoidance training, montanine did not affect avoidance memory retention in rats. Our results suggest that montanine, as other alkaloids isolated from Amaryllidaceae species, has psychopharmacological activities including anxiolytic, antidepressive and anticonvulsive effects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0091-3057 1873-5177
DOI:	10.1016/j.pbb.2006.07.027