Saliva culture as a predictive indicator for current blood infections and antimicrobial resistance in the ICU setting

Antimicrobial resistance is a worldwide health problem and patients in intensive care are more vulnerable, requiring strict control measures and early identification. Currently, clinical culture materials are used to identify the bacterial agent, but saliva culture is not validated, which has great...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 20317
Main Authors:	da Rocha Santos, Leonardo Moura Brasil, de Paula Ramos, Lucas, Santos, Carlos Eduardo Rocha, Miranda, Diego Garcia, Gimenez, Mariana Gadelho, Meccatti, Vanessa Marques, Abu Hasna, Amjad, dos Santos Oliveira, Marcela, Neto, Morun Bernardino, Dias de Oliveira, Luciane
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20-11-2023 Nature Publishing Group Nature Portfolio
Subjects:	692/308 692/699 692/700 Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antimicrobial agents Antimicrobial resistance Blood Blood culture Drug resistance Drug Resistance, Bacterial Humanities and Social Sciences Humans Intensive care Intensive Care Units Klebsiella multidisciplinary Patients Saliva Science Science (multidisciplinary) Secretions
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Antimicrobial resistance is a worldwide health problem and patients in intensive care are more vulnerable, requiring strict control measures and early identification. Currently, clinical culture materials are used to identify the bacterial agent, but saliva culture is not validated, which has great clinical relevance because it participates in several pathophysiological processes. The aim of this study was to validate saliva culture in an intensive care unit environment, determining its diagnostic value for infection. For this purpose, the results of the 39-month surveillance cultures, from the database of a private hospital were evaluated. A total of 323 cultures were paired between saliva, tracheal secretions, blood and urine from patients who were hospitalized for more than 5 days. The search for correlations between the results was performed using the Spearman correlation test. Severity and evolution data were also correlated. It was possible to correlate the presence of Klebsiella spp. between blood culture and saliva culture in 25% of the results (r = 0.01) and the correlation between saliva and tracheal secretion was 33% (r = 0.33447) with p < 0.0001. In conclusion, saliva can be an excellent discriminator of systemic infections, and can be considered a useful culture in clinical practice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-47143-3