Search Results - "da Rocha Araújo, Shyrlene Meiry"
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Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model
Published in Mediators of Inflammation (01-01-2013)“…We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice. Herein,…”
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Sildenafil Alleviates Murine Experimental Autoimmune Encephalomyelitis by Triggering Autophagy in the Spinal Cord
Published in Frontiers in immunology (13-05-2021)“…Multiple Sclerosis (MS) is a neuroinflammatory and chronic Central Nervous System (CNS) disease that affects millions of people worldwide. The search for more…”
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Intraurethral injection with LPS: an effective experimental model of prostatic inflammation
Published in Inflammation research (2018)“…Objective Chronic inflammation has been recognized as having a prominent role pathogenesis of benign prostatic hyperplasia (BPH) and cancer. It is believed…”
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Diethylcarbamazine attenuates LPS-induced acute lung injury in mice by apoptosis of inflammatory cells
Published in Pharmacological reports (01-02-2017)“…Acute lung injury (ALI) is characterized by extensive neutrophil infiltration, and apoptosis delay considered part of the pathogenesis of the condition…”
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Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL/6 mice
Published in Journal of neuroimmunology (15-08-2018)“…Apoptosis is one form of cell death that is intimately related to health and pathological conditions. In most neuroinflammatory and/or neurodegenerative…”
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Effect of sildenafil on neuroinflammation and synaptic plasticity pathways in experimental autoimmune encephalomyelitis
Published in International immunopharmacology (01-08-2020)“…•Sildenafil reduced CD4+ T lymphocytes and IL-17 and TNF-α cytokines.•Sildenafil reduced neuroinflammation in the hippocampus.•Sildenafil induced expression of…”
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Preventive role of metformin on peripheral neuropathy induced by diabetes
Published in International immunopharmacology (01-09-2019)“…Metformin is the first line drug in the treatment of type 2 diabetes, however, little is known about its therapeutic potential to prevent or delay damage to…”
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