Antiviral activity of animal venom peptides and related compounds

Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urge...

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Bibliographic Details
Published in:	The journal of venomous animals and toxins including tropical diseases Vol. 23; no. 1; p. 3
Main Authors:	da Mata, Élida Cleyse Gomes, Mourão, Caroline Barbosa Farias, Rangel, Marisa, Schwartz, Elisabeth Ferroni
Format:	Journal Article
Language:	English
Published:	Brazil BioMed Central Ltd 06-01-2017 Center for the Study of Venoms and Venomous Animals BioMed Central Centro de Estudos de Venenos e Animais Peçonhentos SciELO
Subjects:	Amphibian venom Antiretroviral agents Antiviral agents Candidates Care and treatment Cervical cancer Cytomegalovirus Drug resistance Glycoproteins Health aspects Hepatitis HIV Human immunodeficiency virus Immune system Infections Insect venom Marine animal peptides Natural products Peptides Proteins Review Scorpion venom Snake venom TOXICOLOGY TROPICAL MEDICINE Viral infections Virus diseases Viruses Amphibian venom Antiviral agents Snake venom HIV Antiretroviral agents Scorpion venom Marine animal peptides Insect venom
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Summary:	Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals. Venoms are complex mixtures of hundreds of molecules, mostly peptides, that present a large array of biological activities and evolved to putatively target the biochemical machinery of different pathogens or host cellular structures. In addition, non-venomous compounds, such as some body fluids of invertebrate organisms, exhibit antiviral activity. This review provides a panorama of peptides described from animal venoms that present antiviral activity, thereby reinforcing them as important tools for the development of new therapeutic drugs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1678-9199 1678-9199
DOI:	10.1186/s40409-016-0089-0