Search Results - "da Justa, Hanna Câmara"
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Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?
Published in The journal of venomous animals and toxins including tropical diseases (2021)“…Accidents caused by the bites of brown spiders ( Loxosceles ) generate a clinical condition that often includes a threatening necrotic skin lesion near the…”
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Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs
Published in Frontiers in molecular biosciences (17-06-2021)“…Brown spider (genus Loxosceles ) venoms are mainly composed of protein toxins used for predation and defense. Bites of these spiders most commonly produce a…”
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Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from Three Loxosceles Spider Venoms
Published in International journal of molecular sciences (26-07-2023)“…Spiders of genus are widely distributed and their venoms contain phospholipases D (PLDs), which degrade phospholipids and trigger inflammatory responses,…”
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Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation
Published in Toxins (27-12-2022)“…Bites of spiders can lead to a set of clinical manifestations called loxoscelism, and are considered a public health problem in many regions. The signs and…”
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Forty Years of the Description of Brown Spider Venom Phospholipases-D
Published in Toxins (06-03-2020)“…Spiders of the genus , popularly known as Brown spiders, are considered a serious public health issue, especially in regions of hot or temperate climates, such…”
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Novel insights into the application of recombinant mutated phospholipases D as antigens for developing new strategies against Loxoscelism
Published in Acta tropica (01-10-2024)“…•Neutralization of cutaneous and systemic loxoscelism was assessed.•The sphingomyelinase activity of Loxosceles venoms was neutralized.•Number of immunizations…”
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Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells
Published in Enzyme and microbial technology (01-05-2021)“…•Recombinant brown spider hyaluronidase LiHyal2 isoform is a glycosidase enzyme.•LiHyal2 is the first recombinant brown spider enzyme produced by insect…”
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Description of a serpin toxin in Loxosceles (Brown spider) venoms: Cloning, expression in baculovirus-infected insect cells and functional characterization
Published in International journal of biological macromolecules (31-07-2021)“…Several classes of toxins are present in the venom of Brown spiders (Loxosceles genus), some of them are highly expressed and others are less expressed. In…”
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LALLT (Loxosceles Allergen-Like Toxin) from the venom of Loxosceles intermedia: Recombinant expression in insect cells and characterization as a molecule with allergenic properties
Published in International journal of biological macromolecules (01-12-2020)“…Bites evoked by Brown spiders (Loxosceles genus) are associated with skin injuries (cutaneous rash, itching, swelling, erythema and dermonecrosis) and systemic…”
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Subtranscriptome analysis of phospholipases D in Loxosceles venom glands: Confirmation of predominance, intra-species diversity, and description of novel isoforms
Published in International journal of biological macromolecules (01-11-2024)“…Spiders of Loxosceles genus, or Brown spiders produce a potent venom with minimal volume and protein content. Among its toxins, phospholipases D (PLDs) are…”
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A protective vaccine against the toxic activities following Brown spider accidents based on recombinant mutated phospholipases D as antigens
Published in International journal of biological macromolecules (01-12-2021)“…Accidents involving Brown spiders are reported throughout the world. In the venom, the major toxins involved in the deleterious effects are phospholipases D…”
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Cloning and expression of a Loxosceles intermedia allergen homologous protein
Published in Toxicon (Oxford) (05-10-2019)Get full text
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Induction of ectosome formation by binding of phospholipases D from Loxosceles venoms to endothelial cell surface: Mechanism of interaction
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (13-11-2024)“…Members of the phospholipase D (PLD) superfamily found in Loxosceles spider venoms are potent toxins with inflammatory and necrotizing activities. They degrade…”
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Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from Three ILoxosceles/I Spider Venoms
Published in International journal of molecular sciences (01-07-2023)“…Spiders of Loxosceles genus are widely distributed and their venoms contain phospholipases D (PLDs), which degrade phospholipids and trigger inflammatory…”
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Molecular cloning and characterization of a serpin from Loxosceles intermedia venom gland
Published in Toxicon (Oxford) (05-10-2019)Get full text
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Protective response against toxic effects of Loxosceles spider venoms using recombinant mutated phospholipases-D as antigens
Published in Toxicon (Oxford) (05-10-2019)Get full text
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Phospholipase D from venoms of Loxosceles spiders: a structural, biochemical and biological comparison
Published in Toxicon (Oxford) (05-10-2019)Get full text
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A Novel Isoform of Hyaluronidase of Loxosceles intermedia venom: Production in Baculovirus-Insect Cell Expression System
Published in Toxicon (Oxford) (05-10-2019)Get full text
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