Search Results - "da Guarda, Caroline"
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Investigation of Lipid Profile and Clinical Manifestations in SCA Children
Published in Disease markers (2020)“…Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals…”
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Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
Published in Disease markers (01-01-2018)“…This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under…”
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Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers
Published in PloS one (04-02-2021)“…Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to…”
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4
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
Published in The pharmacogenomics journal (01-12-2018)“…Hydroxyurea (HU) was approved to be used in the treatment of sickle cell disease (SCD) because of its anti-sickling potential. However, there is variability in…”
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Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia
Published in PloS one (15-07-2019)“…This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in…”
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A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126
Published in Biomolecules (Basel, Switzerland) (17-02-2022)“…Sickle leg ulcers (SLU) are malleoli lesions with exuberant hemolytic pathophysiology. The microRNAs are potential genetic biomarkers for several pathologies…”
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Association of the clinical profile and overall survival of pediatric patients with acute lymphoblastic leukemia
Published in Frontiers in pediatrics (07-09-2023)“…IntroductionThe clarification of etiopathology, the improvement of chemotherapy regimens and their risk stratifications, and the improvement in treatment…”
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Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children
Published in Disease markers (01-01-2018)“…Background. The nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change…”
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Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia
Published in Expert review of hematology (03-06-2017)“…Hemolysis triggers the onset of several clinical manifestations of sickle cell anemia (SCA). During hemolysis, heme, which is derived from hemoglobin (Hb),…”
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Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives
Published in Frontiers in endocrinology (Lausanne) (29-09-2017)“…Combined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal…”
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Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles
Published in BMC hematology (15-09-2017)“…In this study, we evaluate the association of different clinical profiles, laboratory and genetic biomarkers in patients with sickle cell anemia (SCA) and…”
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Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
Published in Lipids in health and disease (11-04-2017)“…Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has…”
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Leg Ulcers in Sickle Cell Disease: A Multifactorial Analysis Highlights the Hemolytic Profile
Published in Hematology reports (15-02-2023)“…Sickle cell disease (SCD) is characterized by the presence of the variant S hemoglobin (HbS). The homozygous genotype (HbSS) is sickle cell anemia (SCA), while…”
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Inflammatory mediators in sickle cell anaemia highlight the difference between steady state and crisis in paediatric patients
Published in British journal of haematology (01-09-2018)Get full text
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Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)
Published in PloS one (29-01-2020)“…Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals present highly variable clinical manifestations. Sickle cell anemia…”
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Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies
Published in Microvascular research (01-07-2016)“…The sickle cell disease (SCD) is a hemolytic genetic anemia characterized by free heme and hemoglobin release into intravascular spaces, with endothelial…”
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Genetic modulation of fetal hemoglobin in hydroxyurea‐treated sickle cell anemia
Published in American journal of hematology (01-05-2017)Get full text
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Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease
Published in Scientific reports (03-05-2023)“…Sickle cell disease (SCD) patients often exhibit a dyslipidemic sub-phenotype. Paraoxonase 1 (PON 1) is a serum glycoprotein associated with the high-density…”
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Nasopharyngeal and Oropharyngeal Colonization by Staphylococcus aureus and Streptococcus pneumoniae and Prognostic Markers in Children with Sickle Cell Disease from the Northeast of Brazil
Published in Frontiers in microbiology (15-02-2017)“…We investigated the nasopharynx and oropharynx microbiota in sickle cell disease (SCD) to identify the microorganisms, antibiotic sensitivity, prevalent…”
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Association of homocysteine and inflammatory-related molecules in sickle cell anemia
Published in Hematology (Luxembourg) (07-02-2016)“…Investigate the role of homocysteine (Hcy), Th17-related cytokines, and adhesion molecules in the inflammatory state seen in the sickle cell anemia (SCA). We…”
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