A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation ( C p...

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Bibliographic Details
Published in:Lipids Vol. 46; no. 11; pp. 1071 - 1074
Main Authors: Oliveira, Tchana Weyll Souza, Leandro, Carol Góis, de Jesus Deiró, Tereza Cristina Bomfim, dos Santos Perez, Gabriela, da França Silva, Darlene, Druzian, Janice Izabel, Couto, Ricardo David, Barreto-Medeiros, Jairza Maria
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-11-2011
Springer‐Verlag
Springer Nature B.V
Subjects:
Animals
Biomedical and Life Sciences
Blood Glucose
Cholesterol
Cholesterol - blood
Cholesterolemia
Communication
Critical period of development
Developmental plasticity
Diet
Diet, High-Fat - adverse effects
Eating
Female
Food
Hypercholesterolemia - etiology
Hyperlipidic diet
Life Sciences
Lipidology
Male
Maternal-Fetal Exchange
Medical Biochemistry
Medicinal Chemistry
Metabolic disorders
Microbial Genetics and Genomics
Neurochemistry
Nutrition
Pregnancy
Rats
Rats, Wistar
Triglycerides
Weight Gain
Rats
Cholesterolemia
Developmental plasticity
Hyperlipidic diet
Critical period of development
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Summary:The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation ( C p , n  = 10; pups from control mothers; and HL p n  = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HL p group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.
Bibliography:This work was performed at the Laboratory of Experimental Nutrition, Federal University of Bahia, Brazil.
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ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-011-3604-7