Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam CT

Evidence of genotoxicity and cytotoxicity of X-rays in the oral mucosa epithelium of adults subjected to cone beam CT

To assess cytological evidence of genotoxicity and cytotoxicity of X-rays in oral exfoliated cells of adults subjected to partial and total cone beam CT (CBCT) (stitching module) by means of micronuclei frequency, associated with counting of degenerative nuclear alterations (pyknosis, karyolysis, ka...

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Bibliographic Details
Published in:Dento-maxillo-facial radiology Vol. 47; no. 2; p. 20170160
Main Authors: da Fonte, Juliana Bm, Andrade, Taís M de, Albuquerque, Jr, Ricardo Lc, de Melo, Maria de Fátima B, Takeshita, Wilton M
Format: Journal Article
Language:English
Published: England The British Institute of Radiology 01-02-2018
Subjects:
Adult
Cell Death - radiation effects
Cone-Beam Computed Tomography - adverse effects
CT/CBCT
Dentistry
Female
Humans
Male
Micronucleus Tests
Middle Aged
Mouth Mucosa - cytology
Mouth Mucosa - radiation effects
Physics/Dosimetry/Sensitometry
Radiation Biology
X-Rays
cone-beam computed tomography
micronucleus test
mouth mucosa
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Summary:To assess cytological evidence of genotoxicity and cytotoxicity of X-rays in oral exfoliated cells of adults subjected to partial and total cone beam CT (CBCT) (stitching module) by means of micronuclei frequency, associated with counting of degenerative nuclear alterations (pyknosis, karyolysis, karyorrhexis, buds and broken eggs), besides comparing the partial and total CBCT (stitching module) in search of possible differences in the nature and/or intensity of the effects. 29 adults who were referred to total or partial CBCT were selected. All CBCT were performed with a Carestream CS 9000 3D scanner (Carestream Health Inc., Rochester, NY). Material collection was done immediately before CBCT and 10 days later, by scraping the left and right cheek mucosa with a plastic spatula. Statistical analysis was performed using the Wilcoxon test (paired data), at a significance level of 5%. The statistically significant difference was noted in the frequency of micronucleated cells for both partial and total acquisition (p = 0.008 and p < 0.001, respectively). Regarding to cytotoxicity, there was a statistically significant difference for both partial and total acquisition (p < 0.001 and p < 0.001, respectively). The partial and total CBCT seems to offer risks of inducing genetic damage. In addition both forms of CBCT acquisition have promoted the induction of cytotoxic nuclear alterations.
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ISSN:0250-832X
1476-542X
DOI:10.1259/dmfr.20170160