Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission

The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopi...

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Bibliographic Details
Published in:	Fitoterapia Vol. 143; pp. 104545 - 7
Main Authors:	Magalhães, Herbert S., da Silva, Alison B., Nascimento, Nilberto R.F., de Sousa, Luis Gustavo F., da Fonseca, Maria Júlia S., Loiola, Maria Iracema B., Monteiro, Norberto K.V., Almeida Neto, Francisco Wagner Q., Canuto, Kirley M., Pessoa, Otilia Deusdênia L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2020 Elsevier Science Ltd
Subjects:	Alkaloids Animals Bioassays Brazil Electric Stimulation Ethanol GIAO 13C NMR In Vitro Techniques Indole alkaloids Indole Alkaloids - chemistry Indole Alkaloids - pharmacology Indoles Magnetic Resonance Spectroscopy Male Mice Molecular Structure Neuroinhibitory effect Neurotransmission NMR Norepinephrine Nuclear magnetic resonance Phytochemicals - isolation & purification Phytochemicals - pharmacology Plant Extracts - chemistry Plant Roots - chemistry Rauvolfia Rauvolfia ligustrina Rauwolfia - chemistry Synaptic Transmission - drug effects Vas deferens Vas Deferens - drug effects Brazil Rauvolfia ligustrina Neuroinhibitory effect GIAO 13C NMR Indole alkaloids GIAO C NMR
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Summary:	The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alkaloids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity. [Display omitted]
ISSN:	0367-326X 1873-6971
DOI:	10.1016/j.fitote.2020.104545