Use of tylvalosin-medicated feed to control porcine proliferative enteropathy

The effect of an oral treatment with the tartrate salt of tylvalosin on the development of proliferative enteropathy in 60 experimentally challenged pigs was studied. Thirty of the pigs were fed a diet medicated with 50 ppm tylvalosin and 30 were fed the unmedicated diet. The treated animals started...

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Bibliographic Details
Published in:	Veterinary record Vol. 165; no. 12; pp. 342 - 345
Main Authors:	Guedes, R. M. C., França, S. A., Machado, G. S., Blumer, M. A., da Costa Cruz, E. C.
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Limited 19-09-2009 Blackwell Publishing Ltd
Subjects:	Animal Feed Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Desulfovibrionaceae Infections - prevention & control Desulfovibrionaceae Infections - veterinary Diarrhea Feeds Hogs Ileitis - prevention & control Ileitis - veterinary Salmonella Studies Swine Swine Diseases - microbiology Swine Diseases - prevention & control Time Factors Tylosin - administration & dosage Tylosin - analogs & derivatives Tylosin - therapeutic use Brazil
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Summary:	The effect of an oral treatment with the tartrate salt of tylvalosin on the development of proliferative enteropathy in 60 experimentally challenged pigs was studied. Thirty of the pigs were fed a diet medicated with 50 ppm tylvalosin and 30 were fed the unmedicated diet. The treated animals started to receive the medicated feed the day before they were inoculated, and continued to receive it for 14 days. The pigs' bodyweight, feed consumption and clinical signs were evaluated, and they were examined postmortem 20 days after inoculation, and samples of ileum were collected for immunohistochemistry (IHC) for Lawsonia intracellularis. Clinical signs of the disease were more evident in the untreated group than in the treated group. The average daily weight gain, average daily feed consumption and feed conversion efficiency were better in the treated group. The combined length of intestine with lesions was 2847 cm in the untreated group and 183 cm in the treated group. The tylvalosin treatment significantly reduced the level of L intracellularis infection; almost half of the treated pigs were IHCnegative compared with 3˙3 per cent of the untreated pigs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0042-4900 2042-7670
DOI:	10.1136/vr.165.12.342