Personality, Brain Asymmetry, and Neuroendocrine Reactivity in Two Immune-Mediated Disorders: A Preliminary Report

Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we use...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 16; no. 4; pp. 383 - 397
Main Authors:	Martins, J.Martin, Alves, J., Trinca, Ana, Grima, Bruno, do Vale, S., Vasconcelos, Teresa, Riso, Nuno, Riscado, Vaz, da Costa, J.Charneco
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-08-2002
Subjects:	Adrenocorticotropic Hormone - blood Adult Brain - immunology Brain - physiopathology chronic hepatitis C CRH test Dehydroepiandrosterone Sulfate - blood Edinburgh Manual Preference Index Female Functional Laterality Hepatitis C, Chronic - immunology Hepatitis C, Chronic - physiopathology Hepatitis C, Chronic - psychology Humans Hydrocortisone - blood Key Words: systemic lupus erythematosus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - physiopathology Lupus Erythematosus, Systemic - psychology Male Middle Aged Minnesota Multiphasic Personality Inventory MMPI Neurosecretory Systems - immunology Neurosecretory Systems - physiopathology Personality Pilot Projects Prolactin - blood CRH test Key Words: systemic lupus erythematosus Minnesota Multiphasic Personality Inventory chronic hepatitis C Edinburgh Manual Preference Index
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Summary:	Development of some immune-mediated disorders may depend on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To explore neuropsychologic mechanisms in relation to the abnormal endocrine reactivity in patients with systemic lupus erythematosus (SLE) and chronic hepatitis C (CHC) we used the corticotropin releasing hormone (CRH) test, the Minnesota Multiphasic Personality Inventory (MMPI), and the Edinburgh Inventory of Manual Preference Inventory (EIMP). Compared to controls, the adrenocorticotrophic hormone (ACTH) response to CRH was reduced in CHC, while SLE presented reduced baseline dehydroepiandrosterone sulfate levels; higher neurotic scores were found in SLE and higher behavior deviant scores in CHC. Peak ACTH levels were a significant factor for the MMPI profile variability, while the manual preference score was a significant factor for the ACTH response. Personality and manual preference contribute to neuroendocrine abnormalities. Different behavioral and neuroimmunoendocrine models emerge for these disorders.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0889-1591 1090-2139
DOI:	10.1006/brbi.2001.0636