Search Results - "da Costa, Gonçalo Gamboa"

Effects of a 28-day dietary co-exposure to melamine and cyanuric acid on the levels of serum microRNAs in male and female Fisher 344 rats by Silva, Camila S., Chang, Ching-Wei, Williams, Denita, Porter-Gill, Patricia, Gamboa da Costa, Gonçalo, Camacho, Luísa

“…We showed previously that a 28-day combined dietary exposure to melamine and cyanuric acid (MEL&CYA) induced kidney lesions in NCTR Fisher 344 (F344) rats…”
Get full text

Exceptionally long‐term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy by Schmeiser, Heinz H., Nortier, Joëlle L., Singh, Rajinder, Gamboa da Costa, Gonçalo, Sennesael, Jacques, Cassuto‐Viguier, Elisabeth, Ambrosetti, Damien, Rorive, Sandrine, Pozdzik, Agnieszka, Phillips, David H., Stiborova, Marie, Arlt, Volker M.

“…Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming…”
Get full text

Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay by Von Tungeln, Linda S., Doerge, Daniel R., Gamboa da Costa, Gonçalo, Matilde Marques, M., Witt, William M., Koturbash, Igor, Pogribny, Igor P., Beland, Frederick A.

“…Acrylamide is a high‐volume industrial chemical, a component of cigarette smoke, and a product formed in certain foods prepared at high temperatures…”
Get full text

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice by Arlt, Volker M., Stiborová, Marie, Henderson, Colin J., Thiemann, Markus, Frei, Eva, Aimová, Dagmar, Singh, Rajinder, Gamboa da Costa, Gonçalo, Schmitz, Oliver J., Farmer, Peter B., Wolf, C. Roland, Phillips, David H.

“…Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are…”
Get full text

Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents by POGRIBNY, IGOR P, TRYNDYAK, VOLODYMYR P, POGRIBNA, MARTA, SHPYLEVA, SVITLANA, SURRATT, GORDON, COSTA, GONÇALO GAMBOA DA, BELAND, FREDERICK A

“…Iron plays a vital role in the normal functioning of cells via the regulation of essential cellular metabolic reactions, including several DNA and…”
Get full text

Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats by Camacho, Luísa, Basavarajappa, Mallikarjuna S., Chang, Ching-Wei, Han, Tao, Kobets, Tetyana, Koturbash, Igor, Surratt, Gordon, Lewis, Sherry M., Vanlandingham, Michelle M., Fuscoe, James C., Gamboa da Costa, Gonçalo, Pogribny, Igor P., Delclos, K. Barry

“…•The effects of seven “low BPA”, two “high BPA”, and two EE2 doses versus vehicle control were assessed at the molecular level.•Prostate and mammary glands,…”
Get full text

Reaction of Dehydropyrrolizidine Alkaloids with Valine and Hemoglobin by Zhao, Yuewei, Wang, Shuguang, Xia, Qingsu, Gamboa da Costa, Gonçalo, Doerge, Daniel R, Cai, Lining, Fu, Peter P

“…Pyrrolizidine alkaloid-containing plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids exert…”
Get full text

Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents by Camacho, Luísa, Lewis, Sherry M., Vanlandingham, Michelle M., Juliar, Beth E., Olson, Greg R., Patton, Ralph E., Gamboa da Costa, Gonçalo, Woodling, Kellie, Sepehr, Estatira, Bryant, Matthew S., Doerge, Daniel R., Basavarajappa, Mallikarjuna S., Felton, Robert P., Delclos, K. Barry

“…Diet is an important variable in toxicology. There are mixed reports on the impact of soy components on energy utilization, fat deposition, and reproductive…”
Get full text

High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo by Fu, Peter P, Chou, Ming W, Churchwell, Mona, Wang, Yuping, Zhao, Yuewei, Xia, Qingsu, Gamboa da Costa, Gonçalo, Marques, M. Matilde, Beland, Frederick A, Doerge, Daniel R

“…Pyrrolizidine alkaloid-containing plants are widespread in the world and are probably the most common poisonous plants affecting livestock, wildlife, and…”
Get full text

Characterization of water-soluble organic matter in urban aerosol by 1H-NMR spectroscopy by Chalbot, Marie-Cecile G., Chitranshi, Priyanka, Gamboa da Costa, Gonçalo, Pollock, Erik, Kavouras, Ilias G.

“…The functional and 13C isotopic compositions of water-soluble organic carbon (WSOC) in atmospheric aerosol were determined by nuclear magnetic resonance…”
Get full text

Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure by Bandele, Omari, Camacho, Luísa, Ferguson, Martine, Reimschuessel, Renate, Stine, Cynthia, Black, Thomas, Olejnik, Nicholas, Keltner, Zachary, Scott, Michael, Costa, Gonçalo Gamboa da, Sprando, Robert

“…► Urinary biomarkers have been identified that are proposed to detect renal damage prior to the onset of kidney dysfunction. ► Multiplexed ELISA and gene…”
Get full text

Acrylamide Formed at Physiological Temperature as a Result of Asparagine Oxidation by Tareke, Eden, Heinze, Thomas M, Gamboa da Costa, Gonçalo, Ali, Syed

“…Acrylamide is a probable human carcinogen that is neurotoxic to both humans and animals. It is known to be formed during cooking of foods at temperatures…”
Get full text

Dose–response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats by Gamboa da Costa, Gonçalo, Jacob, Cristina C., Von Tungeln, Linda S., Hasbrouck, Nicholas R., Olson, Greg R., Hattan, David G., Reimschuessel, Renate, Beland, Frederick A.

“…The adulteration of pet food with melamine and derivatives, including cyanuric acid, has been implicated in the kidney failure and death of cats and dogs in…”
Get full text

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry by Singh, Rajinder, Arlt, Volker M., Henderson, Colin J., Phillips, David H., Farmer, Peter B., Costa, Gonçalo Gamboa da

“…The heterocyclic aromatic amine, 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) is formed by the grilled cooking of certain foods such as meats,…”
Get full text

A rapid and highly sensitive UPLC-ESI-MS/MS method for the analysis of the fatty acid profile of edible vegetable oils by Nagumalli, Suresh K., Jacob, Cristina C., Gamboa da Costa, Gonçalo

“…•New method to analyze the fatty acid profile of vegetable oils.•15-Minute transesterification with dimethylaminoethanol (DMAE)•UPLC-ESI-MS/MS analysis of…”
Get full text

Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90 by Delclos, K. Barry, Camacho, Luísa, Lewis, Sherry M., Vanlandingham, Michelle M., Latendresse, John R., Olson, Greg R., Davis, Kelly J., Patton, Ralph E., da Costa, Gonçalo Gamboa, Woodling, Kellie A., Bryant, Matthew S., Chidambaram, Mani, Trbojevich, Raul, Juliar, Beth E., Felton, Robert P., Thorn, Brett T.

“…Bisphenol A (BPA) is a high production volume industrial chemical to which there is widespread human oral exposure. Guideline studies used to set regulatory…”
Get full text

NIEHS/FDA CLARITY-BPA research program update by Heindel, Jerrold J., Newbold, Retha R., Bucher, John R., Camacho, Luísa, Delclos, K. Barry, Lewis, Sherry M., Vanlandingham, Michelle, Churchwell, Mona I., Twaddle, Nathan C., McLellen, Michelle, Chidambaram, Mani, Bryant, Matthew, Woodling, Kellie, Costa, Gonçalo Gamboa da, Ferguson, Sherry A., Flaws, Jodi, Howard, Paul C., Walker, Nigel J., Zoeller, R. Thomas, Fostel, Jennifer, Favaro, Carolyn, Schug, Thaddeus T.

“…Bisphenol A (BPA) is a chemical used in the production of numerous consumer products resulting in potential daily human exposure to this chemical. The FDA…”
Get full text

Absorption and metabolism of triclosan after application to the skin of B6C3F1 mice by Fang, Jia-Long, Vanlandingham, Michelle, da Costa, Gonçalo Gamboa, Beland, Frederick A.

“…ABSTRACT Triclosan is used as an antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Humans can receive…”
Get full text

Quantification of 3-Nitrobenzanthrone-DNA Adducts Using Online Column-Switching HPLC-Electrospray Tandem Mass Spectrometry by Gamboa da Costa, Gonçalo, Singh, Rajinder, Arlt, Volker M, Mirza, Amin, Richards, Meirion, Takamura-Enya, Takeji, Schmeiser, Heinz H, Farmer, Peter B, Phillips, David H

“…The aromatic nitroketone 3-nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one; 3-NBA) is an extremely potent mutagen and a suspected human carcinogen…”
Get full text

Mutagenicity and DNA Adduct Formation by the Urban Air Pollutant 2-Nitrobenzanthrone by Arlt, Volker M., Glatt, Hansruedi, Gamboa da Costa, Gonçalo, Reynisson, Jóhannes, Takamura-Enya, Takeji, Phillips, David H.

“…2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. Its isomer 3-nitrobenzanthrone (3-NBA) is a potent mutagen and…”
Get full text