IFN-gamma and IL-12B polymorphisms in women with cervical intraepithellial neoplasia caused by human papillomavirus

The Human Papillomavirus (HPV) is a sexually transmitted organism associated with Cervical Intraepithelial Neoplasia (CIN) and cervical cancer, the second main cause of malignancy in women worldwide. The virus itself, however, is not enough to cause lesions on the cervix. Several studies suggest tha...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 39; no. 7; pp. 7627 - 7634
Main Authors:	do Carmo Vasconcelos de Carvalho, Viviane, de Macêdo, Jamilly Lopes, de Lima, Camilla Albertina Dantas, da Conceição Gomes de Lima, Maria, de Andrade Heráclio, Sandra, Amorim, Melânia, de Mascena Diniz Maia, Maria, Porto, Ana Lúcia Figueiredo, de Souza, Paulo Roberto Eleutério
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-07-2012 Springer Nature B.V
Subjects:	Alphapapillomavirus Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Cervical cancer Cervical Intraepithelial Neoplasia - epidemiology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology Cervix Female gamma -Interferon Gene polymorphism Genotype Histology Human papillomavirus Humans Interferon-gamma - genetics Interleukin-12 Subunit p40 - genetics Life Sciences Malignancy Morphology Neoplasia Papillomavirus Infections - complications Papillomavirus Infections - virology Polymorphism Polymorphism, Single Nucleotide Population genetics Proteins Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology Interferon-gamma CIN IL-12B HPV Polymorphism
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Summary:	The Human Papillomavirus (HPV) is a sexually transmitted organism associated with Cervical Intraepithelial Neoplasia (CIN) and cervical cancer, the second main cause of malignancy in women worldwide. The virus itself, however, is not enough to cause lesions on the cervix. Several studies suggest that some polymorphic sites changes the cytokines levels and influence the cancer development in HPV infected patients. In this study, we evaluated the presence of functional polymorphisms at +874 (T/A) IFNG and +1188 (A/C) IL - 12B genes in cervical smears samples from 76 healthy women and 162 women, HPV positive, with CIN lesion—CIN I (45), CIN II (55), CIN III (53) and cervical cancer (9)—in Brazilian population. There was no significant differences in genotype ( p = 0.4192) and allele ( p = 0.370; OR = 1.20) distributions between CIN patients and control groups on IFNG allelic polymorphism. Moreover, for IL - 12B gene, there was a significant difference in genotype ( p = 0.015) and allele distribution ( p = 0.014; OR = 0.5754) between the groups. When samples were stratified according to grade of cervical lesion, the AA genotype and A allele were less frequent in the group with low-grade cervical lesions than in group with high-grade cervical lesions ( p = 0.0036 and p = 0.0010; OR = 0.3819, respectively), suggesting that the C allele (mutant) may protect against the emergence of CIN lesions and its progression.
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ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-012-1597-9