Coordination of Thiosemicarbazones and Bis(thiosemicarbazones) to Bismuth(III) as a Strategy for the Design of Metal-Based Antibacterial Agents

Complexes [Bi(2Fo4Ph)Cl2] (1), [Bi(2Ac4Ph)Cl2] (2), [Bi(2Bz4Ph)Cl2] (3), [Bi(H2Gy3DH)Cl3] (4), [Bi(H2Gy4Et)(OH)2Cl] (5), and [Bi(H2Gy4Ph)Cl3] (6) were prepared with pyridine‐2‐carbaldehyde 4‐phenylthiosemicarbazone (H2Fo4Ph), 1‐(pyridin‐2‐yl)ethanone 4‐phenylthiosemicarbazone (H2Ac4Ph), phenyl(pyrid...

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Bibliographic Details
Published in:	Chemistry & biodiversity Vol. 9; no. 9; pp. 1955 - 1966
Main Authors:	Lessa, Josane A., Reis, Débora C., Da Silva, Jeferson G., Paradizzi, Lúcia T., da Silva, Nayane F., de Fátima A. Carvalho, Mariany, Siqueira, Sarah A., Beraldo, Heloisa
Format:	Journal Article
Language:	English
Published:	Zürich WILEY-VCH Verlag 01-09-2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial agents Bacteria - drug effects Bismuth Bismuth - chemistry Bismuth complexes Coordination Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Crystallography, X-Ray Enterococcus - drug effects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Models, Molecular Molecular Structure Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Thiosemicarbazones Thiosemicarbazones - chemical synthesis Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology
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Summary:	Complexes [Bi(2Fo4Ph)Cl2] (1), [Bi(2Ac4Ph)Cl2] (2), [Bi(2Bz4Ph)Cl2] (3), [Bi(H2Gy3DH)Cl3] (4), [Bi(H2Gy4Et)(OH)2Cl] (5), and [Bi(H2Gy4Ph)Cl3] (6) were prepared with pyridine‐2‐carbaldehyde 4‐phenylthiosemicarbazone (H2Fo4Ph), 1‐(pyridin‐2‐yl)ethanone 4‐phenylthiosemicarbazone (H2Ac4Ph), phenyl(pyridin‐2‐yl)methanone 4‐phenylthiosemicarbazone (H2Bz4Ph), as well as with glyoxaldehyde bis(thiosemicarbazone) (H2Gy4DH) and its 4‐Et (H2Gy4Et) and 4‐Ph (H2Gy4Ph) derivatives. The complexes exhibited antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Pseudomonas aeruginosa. Coordination to BiIII proved to be an effective strategy to increase the antibacterial activity of the thiosemicarbazones and bis(thiosemicarbazones).
Bibliography:	ArticleID:CBDV201100447 istex:74541A46EA3AE8A2255AFC9329613E063A8BE488 ark:/67375/WNG-0NWGKKVZ-G ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.201100447