Search Results - "d’Arcy, Richard"

Amphiphilic polysaccharides as building blocks for self-assembled nanosystems: molecular design and application in cancer and inflammatory diseases by Yang, Xiaoye, Shi, Xiaoqun, D'arcy, Richard, Tirelli, Nicola, Zhai, Guangxi

“…Polysaccharides (PSs) have been extensively studied in healthcare applications; here, we focus our attention on their use as components of nanomaterials in the…”
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Engineering approaches for RNA-based and cell-based osteoarthritis therapies by DeJulius, Carlisle R., Walton, Bonnie L., Colazo, Juan M., d’Arcy, Richard, Francini, Nora, Brunger, Jonathan M., Duvall, Craig L.

“…Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of life of affected individuals. The underlying mechanisms of OA…”
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Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction by Vanderburgh, Joseph, Hill, Jordan L, Gupta, Mukesh K, Kwakwa, Kristin A, Wang, Sean K, Moyer, Kathleen, Bedingfield, Sean K, Merkel, Alyssa R, d’Arcy, Richard, Guelcher, Scott A, Rhoades, Julie A, Duvall, Craig L

“…Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility,…”
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Nanomanufacturing through microfluidic-assisted nanoprecipitation: Advanced analytics and structure-activity relationships by Donno, Roberto, Gennari, Arianna, Lallana, Enrique, De La Rosa, Julio M. Rios, d’Arcy, Richard, Treacher, Kevin, Hill, Kathryn, Ashford, Marianne, Tirelli, Nicola

“…[Display omitted] We have employed microfluidics (cross-shaped chip) for the preparation of drug-loaded poly(lactic acid-co-glycolic acid) (PLGA)…”
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A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors by d’Arcy, Richard, El Mohtadi, Farah, Francini, Nora, DeJulius, Carlisle R., Back, Hyunmoon, Gennari, Arianna, Geven, Mike, Lopez-Cavestany, Maria, Turhan, Zulfiye Yesim, Yu, Fang, Lee, Jong Bong, King, Michael R., Kagan, Leonid, Duvall, Craig L., Tirelli, Nicola

“…This study addresses well-known shortcomings of poly­(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome…”
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Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing by Patel, Shrusti S., Hoogenboezem, Ella N., Yu, Fang, DeJulius, Carlisle R., Fletcher, R. Brock, Sorets, Alex G., Cherry, Fiona K., Lo, Justin H., Bezold, Mariah G., Francini, Nora, d’Arcy, Richard, Brasuell, Jordan E., Cook, Rebecca S., Duvall, Craig L.

“…Gene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized for inhibition of tumor driver genes. Ternary si-NPs containing…”
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Influence of Chain Primary Structure and Topology (Branching) on Crystallization and Thermal Properties: The Case of Polysulfides by Pérez-Camargo, Ricardo A, d’Arcy, Richard, Iturrospe, Amaia, Arbe, Arantxa, Tirelli, Nicola, Müller, Alejandro J

“…We have investigated how variations in primary structure (distribution of monomeric units, chain length) and degree of branching affect the crystallization…”
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Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles by Fletcher, R. Brock, Stokes, Larry D., Kelly, Isom B., Henderson, Katelyn M., Vallecillo-Viejo, Isabel C., Colazo, Juan M., Wong, Benjamin V., Yu, Fang, d’Arcy, Richard, Struthers, Morgan N., Evans, Brian C., Ayers, Jacob, Castanon, Matthew, Weirich, Michael J., Reilly, Sarah K., Patel, Shrusti S., Ivanova, Yoanna I., Silvera Batista, Carlos A., Weiss, Sharon M., Gersbach, Charles A., Brunger, Jonathan M., Duvall, Craig L.

“…The complexity of CRISPR machinery is a challenge to its application for nonviral in vivo therapeutic gene editing. Here, we demonstrate that proteins,…”
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Core Cross‐Linking Enhances the Anti‐Inflammatory Performance of Oxidation‐Sensitive Polymeric Micelles by d'Arcy, Richard, Tirelli, Nicola

“…Nanomaterials able to scavenge biologically relevant oxidants (reactive oxygen species, ROS) can directly act as anti‐inflammatory agents. Here, micelles made…”
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Sustainable Active Food Packaging from Poly(lactic acid) and Cocoa Bean Shells by Papadopoulou, Evie L, Paul, Uttam C, Tran, Thi Nga, Suarato, Giulia, Ceseracciu, Luca, Marras, Sergio, d’Arcy, Richard, Athanassiou, Athanassia

“…Sustainable biocomposites have been developed by solvent mixing of poly­(lactic acid) (PLA) with a fine powder of cocoa bean shells (CBS) and subsequent…”
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Influence of Primary Structure on Responsiveness. Oxidative, Thermal, and Thermo-Oxidative Responses in Polysulfides by d’Arcy, Richard, Siani, Alessandro, Lallana, Enrique, Tirelli, Nicola

“…Using polymers with a double stimulus responsiveness, we show that primary structure, in addition to chemical composition, can significantly influence the…”
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Main Chain Polysulfoxides as Active 'Stealth' Polymers with Additional Antioxidant and Anti-Inflammatory Behaviour by El Mohtadi, Farah, d'Arcy, Richard, Yang, Xiaoye, Turhan, Zulfiye Yesim, Alshamsan, Aws, Tirelli, Nicola

“…We present the evaluation of a sulfoxide-based polymer (poly(propylene sulfoxide), PPSO) as a potential 'stealth' macromolecule, and at the same time as a…”
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Versatile Preparation of Branched Polylactides by Low-Temperature, Organocatalytic Ring-Opening Polymerization in N‑Methylpyrrolidone and Their Surface Degradation Behavior by Scoponi, Giulia, Francini, Nora, Paradiso, Veronica, Donno, Roberto, Gennari, Arianna, d’Arcy, Richard, Capacchione, Carmine, Athanassiou, Athanassia, Tirelli, Nicola

“…We describe how the organocatalytic, 1,8-diazabicyclo[5.4.0]­undec-7-ene (DBU)-based lactide ring-opening polymerization can be effectively performed in a very…”
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The Effect of Branching (Star Architecture) on Poly(d,l‑lactide) (PDLLA) Degradation and Drug Delivery by Burke, Jason, Donno, Roberto, d’Arcy, Richard, Cartmell, Sarah, Tirelli, Nicola

“…This study focuses on the comparative evaluation of star (branched) and linear poly­(l,d-lactic acid) (PDLLA) as degradable materials employed in controlled…”
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Dual Thermal- and Oxidation-Responsive Polymers Synthesized by a Sequential ROP-to-RAFT Procedure Inherently Temper Neuroinflammation by Turhan, Zulfiye Y., d’Arcy, Richard, El Mohtadi, Farah, Teixeira, Lorena Infante, Francini, Nora, Geven, Mike, Castagnola, Valentina, Alshamsan, Aws, Benfenati, Fabio, Tirelli, Nicola

“…This study is about multiple responsiveness in biomedical materials. This typically implies “orthogonality” (i.e., one response does not affect the other) or…”
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Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair by Patil, Prarthana, Russo, Katherine A, McCune, Joshua T, Pollins, Alonda C, Cottam, Matthew A, Dollinger, Bryan R, DeJulius, Carlisle R, Gupta, Mukesh K, D'Arcy, Richard, Colazo, Juan M, Yu, Fang, Bezold, Mariah G, Martin, John R, Cardwell, Nancy L, Davidson, Jeffrey M, Thompson, Callie M, Barbul, Adrian, Hasty, Alyssa H, Guelcher, Scott A, Duvall, Craig L

“…Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds…”
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“Tandem” Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin by El Mohtadi, Farah, d’Arcy, Richard, Burke, Jason, Rios De La Rosa, Julio M, Gennari, Arianna, Marotta, Roberto, Francini, Nora, Donno, Roberto, Tirelli, Nicola

“…We show the first example of a synergic approach of oxidant (ROS) scavenging carrier and ROS-responsive drug release in the context of a potential therapy…”
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Branched polyesters: Preparative strategies and applications by d'Arcy, Richard, Burke, Jason, Tirelli, Nicola

“…In the last 20years, the availability of precision chemical tools (e.g. controlled/living polymerizations, ‘click’ reactions) has determined a step change in…”
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Intravascular delivery of an MK2 inhibitory peptide to prevent restenosis after angioplasty by Tierney, J. William, Francisco, R. Paolo, Yu, Fang, Ma, Jinqi, Cheung-Flynn, Joyce, Keech, Megan C., D’Arcy, Richard, Shah, Veeraj M., Kittel, Anna R., Chang, Devin J., McCune, Joshua T., Bezold, Mariah G., Aligwekwe, Adrian N., Cook, Rebecca S., Beckman, Joshua A., Brophy, Colleen M., Duvall, Craig L.

“…Peripheral artery disease is commonly treated with balloon angioplasty, a procedure involving minimally invasive, transluminal insertion of a catheter to the…”
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Mitsunobu Reaction: A Versatile Tool for PEG End Functionalization by d'Arcy, Richard, Tirelli, Nicola

“…The Mitsunobu reaction can be efficiently used for the transformation of poly(ethylene glycol) (PEG) terminal OH group(s) into a variety of functions. In…”
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