Search Results - "d’Apice, Anthony J.F."

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice by CHIA, Joanne S. J, McRAE, Jennifer L, COWAN, Peter J, DWYER, Karen M, THOMAS, Helen E, FYNCH, Stacey, ELKERBOUT, Lorraine, HILL, Prue, MURRAY-SEGAL, Lisa, ROBSON, Simon C, CHEN, Jiang-Fan, D'APICE, Anthony J. F

“…Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors…”
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Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury by Cai, Ming, Huttinger, Zachary M, He, Heng, Zhang, Weizhi, Li, Feng, Goodman, Lauren A, Wheeler, Debra G, Druhan, Lawrence J, Zweier, Jay L, Dwyer, Karen M, He, Guanglong, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Abstract Modulation of purinergic signaling is critical to myocardial homeostasis. Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which…”
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Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function by MYSORE, Tharun B, SHINKEL, Trixie A, CHANDRA, Abhilash P, O'CONNELL, Philip J, D'APICE, Anthony J. F, COWAN, Peter J, COLLINS, James, SALVARIS, Evelyn J, FISICARO, Nella, MURRAY-SEGAL, Lisa J, JOHNSON, Lucinda E. A, LEPORE, Diana A, WALTERS, Stacey N, STOKES, Rebecca

“…Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft…”
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CD39 EXPRESSION MODULATES ISCHEMIA INDUCED DIASTOLIC DYSFUNCTION by Xu, Zhaobin, Gokce, Sibel, Mahamud, Shouvik D, Wheeler, Debra G, Dwyer, Karen M, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Methods Wild-type littermate control (WT), CD39 transgenic (Tg) or CD39 knockout (KO) mice were subjected to 20 minutes of in vivo ischemia induced by ligation…”
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Genetic modification of pigs for solid organ xenotransplantation by Gock, Hilton, Nottle, Mark, Lew, Andrew M, d'Apice, Anthony J.F, Cowan, Peter

“…Abstract Xenotransplantation of solid organs will only ever become a clinical reality with genetic modification of the pig, which is now widely accepted as the…”
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Xenotransplantation: The next generation of engineered animals by d'Apice, Anthony J.F, Cowan, Peter J

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Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission by Yilmaz, Bahtiyar, Portugal, Silvia, Tran, Tuan M., Gozzelino, Raffaella, Ramos, Susana, Gomes, Joana, Regalado, Ana, Cowan, Peter J., d’Apice, Anthony J.F., Chong, Anita S., Doumbo, Ogobara K., Traore, Boubacar, Crompton, Peter D., Silveira, Henrique, Soares, Miguel P.

“…Glycosylation processes are under high natural selection pressure, presumably because these can modulate resistance to infection. Here, we asked whether…”
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Kidney xenotransplantation by Cowan, Peter J, Cooper, David K C, d'Apice, Anthony J F

“…Xenotransplantation using pigs as donors offers the possibility of eliminating the chronic shortage of donor kidneys, but there are several obstacles to be…”
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Transgenic swine: Expression of human CD39 protects against myocardial injury by Wheeler, Debra G, Joseph, Matthew E, Mahamud, Shouvik D, Aurand, William L, Mohler, Peter J, Pompili, Vincent J, Dwyer, Karen M, Nottle, Mark B, Harrison, Sharon J, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Abstract CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5′-nucleotidase…”
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Liver grafts from CD39‐overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells by Pommey, Sandra, Lu, Bo, McRae, Jennifer, Stagg, John, Hill, Prue, Salvaris, Evelyn, Robson, Simon C., d'Apice, Anthony J.F., Cowan, Peter J., Dwyer, Karen M.

“…Ischemia‐reperfusion injury (IRI) is a major limiting event for successful liver transplantation, and CD4+ T cells and invariant natural killer T (iNKT) cells…”
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Ectonucleotide Triphosphate Diphosphohydrolase-1 (CD39) Mediates Resistance to Occlusive Arterial Thrombus Formation after Vascular Injury in Mice by Huttinger, Zachary M, Milks, Michael W, Nickoli, Michael S, Aurand, William L, Long, Lawrence C, Wheeler, Debra G, Dwyer, Karen M, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of…”
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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation by Dwyer, Karen M, Robson, Simon C, Nandurkar, Harshal H, Campbell, Duncan J, Gock, Hilton, Murray-Segal, Lisa J, Fisicaro, Nella, Mysore, Tharun B, Kaczmarek, Elzbieta, Cowan, Peter J, d'Apice, Anthony J F

“…Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment,…”
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Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase from Legionella pneumophila: SUBSTRATE SPECIFICITY AND REQUIREMENT FOR VIRULENCE by Sansom, Fiona M, Riedmaier, Patrice, Newton, Hayley J, Dunstone, Michelle A, Müller, Christa E, Stephan, Holger, Byres, Emma, Beddoe, Travis, Rossjohn, Jamie, Cowan, Peter J, d'Apice, Anthony J.F, Robson, Simon C, Hartland, Elizabeth L

“…Legionella pneumophila is the predominant cause of Legionnaires disease, a severe and potentially fatal form of pneumonia. Recently, we identified an…”
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bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila by Sansom, Fiona M, Newton, Hayley J, Crikis, Sandra, Cianciotto, Nicholas P, Cowan, Peter J, d'Apice, Anthony J.F, Hartland, Elizabeth L

“…As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that do not mature into…”
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Crystal Structure of a Legionella pneumophila Ecto -Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases by Vivian, Julian P., Riedmaier, Patrice, Ge, Honghua, Le Nours, Jérôme, Sansom, Fiona M., Wilce, Matthew C.J., Byres, Emma, Dias, Manisha, Schmidberger, Jason W., Cowan, Peter J., d'Apice, Anthony J.F., Hartland, Elizabeth L., Rossjohn, Jamie, Beddoe, Travis

“…Many pathogenic bacteria have sophisticated mechanisms to interfere with the mammalian immune response. These include the disruption of host extracellular ATP…”
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Production of Cloned Pigs from Cultured Fetal Fibroblast Cells by Boquest, Andrew C, Grupen, Christopher G, Harrison, Sharon J, McIlfatrick, Stephen M, Ashman, Rodney J, d'Apice, Anthony J. F, Nottle, Mark B

“…Somatic cell nuclear transfer was used to produce live piglets from cultured fetal fibroblast cells. This was achieved by exposing donor cell nuclei to oocyte…”
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Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest by Moore, Gregory T.C., Brown, Steven J., Winterhalter, Adam C., Lust, Mark, Salvaris, Evelyn J., Selan, Carly, Nandurkar, Harshal H., Desmond, Paul V., Cowan, Peter J., d’Apice, Anthony J.F.

“…Glycosylation of cell surface proteins is important in thymocyte maturation. In particular, the level of sialylation of key glycoproteins such as CD45 is…”
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Salutary roles of CD39 in transplantation by Dwyer, Karen M, Deaglio, Silvia, Crikis, Sandra, Gao, Wenda, Enjyoji, Keiichi, Strom, Terry B, Cowan, Peter J, d'Apice, Anthony J.F, Robson, Simon C

“…Abstract Transplantation exposes vascularized grafts to several potential injuries, including ischemia-reperfusion injury and rejection. These processes are…”
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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation by Dwyer, Karen M., Robson, Simon C., Nandurkar, Harshal H., Campbell, Duncan J., Gock, Hilton, Murray-Segal, Lisa J., Fisicaro, Nella, Mysore, Tharun B., Kaczmarek, Elzbieta, Cowan, Peter J., d’Apice, Anthony J.F.

“…Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment,…”
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Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice by Lehnert, Anne M, Mottram, Patricia L, Han, Wenruo, Walters, Stacey N, Patel, Anita T, Hawthorne, Wayne J, Cowan, Peter J, d'Apice, Anthony J.F, O'Connell, Philip J

“…Previously, we demonstrated that combination CTLA4-Fc and anti-CD40L mAb treatment results in tolerance to concordant, cellular islet xenografts. The aim of…”
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