Search Results - "d'Arbigny, P"
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Efficacy of a new neuroprotective agent, gacyclidine, in a model of rat spinal cord injury
Published in Journal of neurotrauma (01-11-2000)“…Prevention of the immediate excitotoxic phase occurring in response to spinal cord injury (SCI) is a major issue to reduce the neuronal damage responsible for…”
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Neuroprotective effect of gacyclidine: A multicenter double-blind pilot trial in patients with acute traumatic brain injury
Published in Neuro-chirurgie (01-06-2004)“…The aim of this study was to assess the safety and efficacy of intravenous (IV) injections of gacyclidine, a novel NMDA receptor antagonist, for neurological…”
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Protection of polyunsaturated fatty acids against iron-dependent lipid peroxidation by a Ginkgo biloba extract (EGb 761)
Published in Methods and findings in experimental and clinical pharmacology (01-03-1995)“…Iron can induce a peroxidative degradation of the membrane polyunsaturated fatty acids by the well-known Fenton reaction. Chelated iron can also form a complex…”
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Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats
Published in Brain research (25-08-2000)“…The aim of this study was to analyze the optimal time-window for neuroprotection by a novel NMDA antagonist, Gacyclidine, after experimental spinal cord…”
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Ginkgo biloba extract (EGB 761) pretreatment limits free radical-induced oxidative stress in patients undergoing coronary bypass surgery
Published in Cardiovascular drugs and therapy (01-04-1997)“…A growing body of evidence supports the trigger role of free radicals in the delayed functional and metabolic myocardial recovery following cardiopulmonary…”
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Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: dose-window and time-window effects
Published in Journal of neurotrauma (01-01-2000)“…The aim of this study was to evaluate the efficacy, optimal dose, and optimal time-window of gacyclidine, a novel N-methyl-D-aspartate (NMDA) receptor…”
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Ascorbyl free radical: a noninvasive marker of oxidative stress in human open-heart surgery
Published in Free radical biology & medicine (01-04-1994)“…To assess the development of oxidative stress in cardiac ischemia/reperfusion, the resulting depletion of plasma ascorbate was monitored by electron spin…”
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Pharmacokinetics of gacyclidine enantiomers in plasma and spinal cord after single enantiomer administration in rats
Published in International journal of pharmaceutics (23-10-2001)“…The purpose of this study was to determine the pharmacokinetics of gacyclidine, a non-competitive NMDA antagonist, in plasma and spinal cord extracellular…”
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Sensitive gas chromatographic-mass spectrometric method for the determination of gacyclidine in rat plasma and spinal cord dialyzates
Published in Analyst (London) (01-12-1999)“…A sensitive gas chromatographic-mass spectrometric (GC-MS) procedure is described for the selective determination of gacyclidine (a non-competitive…”
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Distribution of gacyclidine enantiomers in spinal cord extracellular fluid
Published in Pharmaceutical research (01-02-2000)“…Determination of the pharmacokinetics of gacyclidine enantiomers, a non-competitive NMDA antagonist, in plasma and spinal cord extracellular fluid (ECF) of…”
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Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system
Published in Journal of pharmaceutical sciences (01-01-2001)“…The pharmacokinetics of gacyclidine enantiomers, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were studied in plasma and spinal cord extracellular…”
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Effect of Ginkgo biloba extract (EGb 761) on the vasospastic response of mouse cutaneous arterioles to platelet activation
Published in International journal of microcirculation: clinical and experimental (01-03-1997)“…The effect of intravenously administered Ginkbo biloba extract (EGb 761) on the vasospastic response to platelet activation has been assessed using a cutaneous…”
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Effect of two doses of ginkgo biloba extract (EGb 761) on the dual-coding test in elderly subjects
Published in Clinical therapeutics (01-05-1993)“…The subjects of this double-blind study were 18 elderly men and women (mean age, 69.3 years) with slight age-related memory impairment. In a crossover-study…”
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EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure
Published in Aviation, space, and environmental medicine (01-05-1996)“…We recruited 44 subjects to participate in a study of the preventive effect of Ginko biloba extract (EGb 761) on acute mountain sickness (AMS) and vasomotor…”
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Determination of gacyclidine enantiomers in human plasma by gas chromatography–mass spectrometry using selected-ion monitoring
Published in Journal of chromatography. B, Biomedical sciences and applications (19-12-1997)“…A sensitive gas chromatographic assay using mass selective-detection has been developed for the simultaneous quantitation of the enantiomers of (±)-gacyclidine…”
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Modified gas chromatographic–mass spectrometric assay for the determination of gacyclidine enantiomers in human plasma
Published in Journal of chromatography. B, Biomedical sciences and applications (20-08-1999)“…A modified method for the determination of gacyclidine enantiomers in human plasma by GC–MS with selected-ion monitoring using the deuterated derivative of…”
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