Search Results - "d'Apice, A.J.F"

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons by Le Bas-Bernardet, S, Tillou, X, Poirier, N, Dilek, N, Chatelais, M, Devallière, J, Charreau, B, Minault, D, Hervouet, J, Renaudin, K, Crossan, C, Scobie, L, Cowan, P.J, d'Apice, A.J.F, Galli, C, Cozzi, E, Soulillou, J.P, Vanhove, B, Blancho, G

“…Abstract Galactosyl-transferase knockout (GT-KO) pigs represent the latest major progress to reduce immune reactions in xenotransplantation. However, their…”
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Human Endothelial Protein C Receptor Overexpression Protects Intraportal Islet Grafts in Mice by Gock, H, Lee, K.F.E, Murray-Segal, L, Mysore, T.B, d'Apice, A.J.F, Salvaris, E.J, Cowan, P.J

“…Abstract Islet transplantation can potentially cure type 1 diabetes mellitus, but it is limited by a shortage of human donors as well as by islet graft…”
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Protective Effects of Recombinant Human Antithrombin III in Pig‐to‐Primate Renal Xenotransplantation by Cowan, P. J., Aminian, A., Barlow, H., Brown, A. A., Dwyer, K., Filshie, R. J. A., Fisicaro, N., Francis, D. M. A., Gock, H., Goodman, D. J., Katsoulis, J., Robson, S. C., Salvaris, E., Shinkel, T. A., Stewart, A. B., D'Apice, A. J. F.

“…Delayed rejection of pig kidney xenografts by primates is associated with vascular injury that may be accompanied by a form of consumptive coagulopathy in…”
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Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons by Hawthorne, W. J., Salvaris, E. J., Phillips, P., Hawkes, J., Liuwantara, D., Burns, H., Barlow, H., Stewart, A. B., Peirce, S. B., Hu, M., Lew, A. M., Robson, S. C., Nottle, M. B., D'Apice, A. J. F., O'Connell, P. J., Cowan, P. J.

“…The instant blood‐mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher…”
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Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI by Roussel, J. C., Moran, C. J., Salvaris, E. J., Nandurkar, H. H., D'Apice, A. J. F., Cowan, P. J.

“…Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in…”
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Altered Glycosylation in Donor Mice Causes Rejection of Strain‐Matched Skin and Heart Grafts by Gock, H., Murray‐Segal, L. J., Winterhalter, A. C., Aminian, A., Moore, G. T. C., Brown, S. J., d'Apice, A. J. F., Cowan, P. J.

“…Differential protein glycosylation in the donor and recipient can have profound consequences for transplanted organs, as evident in ABO‐incompatible…”
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Protective Effects of Transgenic Human Endothelial Protein C Receptor Expression in Murine Models of Transplantation by Lee, K. F. E., Lu, B., Roussel, J. C., Murray‐Segal, L. J., Salvaris, E. J., Hodgkinson, S. J., Hall, B. M., d'Apice, A. J. F., Cowan, P. J., Gock, H.

“…Thrombosis and inflammation are major obstacles to successful pig‐to‐human solid organ xenotransplantation. A potential solution is genetic modification of the…”
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Antiinflammatory and Anticoagulant Effects of Transgenic Expression of Human Thrombomodulin in Mice by Crikis, S., Zhang, X. M., Dezfouli, S., Dwyer, K. M., Murray‐Segal, L. M., Salvaris, E., Selan, C., Robson, S. C., Nandurkar, H. H., Cowan, P. J., D’Apice, A. J. F.

“…Thrombomodulin (TBM) is an important vascular anticoagulant that has species specific effects. When expressed as a transgene in pigs, human (h)TBM might…”
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Transgenic Overexpression of CD39 Protects Against Renal Ischemia‐Reperfusion and Transplant Vascular Injury by Crikis, S., Lu, B., Murray‐Segal, L. M., Selan, C., Robson, S. C., D’Apice, A. J. F., Nandurkar, H. H., Cowan, P. J., Dwyer, K. M.

“…The vascular ectonucleotidases CD39[ENTPD1 (ectonucleoside triphosphate diphosphohydrolase‐1), EC 3.6.1.5] and CD73[EC 3.1.3.5] generate adenosine from…”
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Blood Group A Transgenic Mice: A Model for ABO-Incompatible (ABOi) Heart Transplantation (HTx) by Kratochvil, A, Motyka, B, Aizouki, F, Wang, S, Tao, K, Tollenaar, S, Bennett, J, Marshall, T, d’Apice, A.J.F, Cowan, P.J, West, L.J

“…Purpose Our group demonstrated that infant ABOi HTx results in development of immune tolerance to donor ABO antigen(s). We recently developed mice transgenic…”
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Production of pigs expressing multiple transgenes for use in xenotransplantation studies by Nottle, M.B, Verma, P.J, Du, Z.T, Grupen, C.G, McIlfatrick, S.M, Ashman, R.J, Chen, C.G, Salvaris, E, Fisicaro, N, Shinkel, T.A, Gianakis, C, Wigley, P.L, Lyons, I.G, Cowan, P.J, Crawford, R.J, Tolstoshev, P.L, Pearse, M.J, Robins, A.J, d'Apice, A.J.F

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Bortezomib, C1‐Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi‐Transgenic GalT‐KO Pig Kidney Xenografts in Baboons by Le Bas‐Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B., Salvaris, E. J., Cowan, P. J., d'Apice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J.‐P., Vanhove, B., Blancho, G.

“…Galactosyl‐transferase KO (GalT‐KO) pigs represent a potential solution to xenograft rejection, particularly in the context of additional genetic…”
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Demonstration of the functional importance of the Gal epitope in an ex vivo model of xenotransplantation by Iange, M.J., Tearle, R.G., Aminian, L., Romanella, M., Adam, W.R., Pearse, M.J., D'Apice, A.J.F.

“…: The galactose a 1‐3 galactose terminal disaccharide (Gal epitope) has been identified as the major porcine xenoantigen recognised by xenoantibody in human…”
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Genetic modification for xenotransplantation: transgenics and clones by d’Apice, A.J.F, Nottle, M.B, Cowan, P.J

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Anti–α1,3-Galactose–Mediated hyperacute rejection of vascularized transplants in a small animal model by Gock, H, Salvaris, E, Han, W, Murray-Segal, L, Mottram, P, Cowan, P, Goodman, D.J, d’Apice, A.J.F

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Suppressor cells assayed by three different methods in patients with chronic active hepatitis and systemic lupus erythematosus by Coovadia, H M, MacKay, I R, d'Apice, A J

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