Search Results - "bertomeu, thierry"

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia by Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

“…To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. Mubritinib, a known ERBB2…”
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A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome by Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Chatr-aryamontri, Andrew, Bourdages, Karine G., Coyaud, Etienne, Raught, Brian, Xia, Yu, Tyers, Mike

“…To interrogate genes essential for cell growth, proliferation and survival in human cells, we carried out a genome-wide clustered regularly interspaced short…”
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Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations by Normandin, Karine, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bernard, Alexandre, Bourouh, Mohammed, Bertomeu, Thierry, Tyers, Mike, Archambault, Vincent

“…Polo-like kinase 1 (PLK1) is a serine/threonine kinase required for mitosis and cytokinesis. As cancer cells are often hypersensitive to partial PLK1…”
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Dinoflagellate tandem array gene transcripts are highly conserved and not polycistronic by Beauchemin, Mathieu, Roy, Sougata, Daoust, Philippe, Dagenais-Bellefeuille, Steve, Bertomeu, Thierry, Letourneau, Louis, Lang, B. Franz, Morse, David

“…Dinoflagellates are an important component of the marine biota, but a large genome with high–copy number (up to 5,000) tandem gene arrays has made genomic…”
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Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways by Hill, Spencer, Reichermeier, Kurt, Scott, Daniel C, Samentar, Lorena, Coulombe-Huntington, Jasmin, Izzi, Luisa, Tang, Xiaojing, Ibarra, Rebeca, Bertomeu, Thierry, Moradian, Annie, Sweredoski, Michael J, Caberoy, Nora, Schulman, Brenda A, Sicheri, Frank, Tyers, Mike, Kleiger, Gary

“…The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme,…”
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Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells by Bucur, Octavian, Stancu, Andreea Lucia, Goganau, Ioana, Petrescu, Stefana Maria, Pennarun, Bodvael, Bertomeu, Thierry, Dewar, Rajan, Khosravi-Far, Roya

“…Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new…”
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UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex by Chagraoui, Jalila, Girard, Simon, Spinella, Jean-Francois, Simon, Laura, Bonneil, Eric, Mayotte, Nadine, MacRae, Tara, Coulombe-Huntington, Jasmin, Bertomeu, Thierry, Moison, Celine, Tomellini, Elisa, Thibault, Pierre, Tyers, Mike, Marinier, Anne, Sauvageau, Guy

“…Human hematopoietic stem cells (HSCs) exhibit attrition of their self-renewal capacity when cultured ex vivo, a process that is partially reversed upon…”
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Abstract 2635: Targeting virus-induced vulnerabilities using synthetic lethality as a new class of host-based antivirals by Navare, Arti, Mast, Fred, Olivier, Paul, Bertomeu, Thierry, Neal, Maxwell, Kaushansky, Alexis, Coulombe-Huntington, Jasmin, Tyers, Mike, Aitchison, John

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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development by Jacques, Samuel, van der Sloot, Almer M, C. Huard, Caroline, Coulombe-Huntington, Jasmin, Tsao, Sarah, Tollis, Sylvain, Bertomeu, Thierry, Culp, Elizabeth J, Pallant, Daniel, Cook, Michael A, Bonneil, Eric, Thibault, Pierre, Wright, Gerard D, Tyers, Mike

“…Abstract The imipridones ONC201 and ONC212 selectively kill cancer cells and have been ascribed multiple mechanisms-of-action. Genome-wide CRISPR knockout…”
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Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells by Benslimane, Yahya, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, McQuaid, Mary, Sánchez-Osuna, María, Papadopoli, David, Avizonis, Daina, Russo, Mariana De Sa Tavares, Huard, Caroline, Topisirovic, Ivan, Wurtele, Hugo, Tyers, Mike, Harrington, Lea

“…Resveratrol is a natural product associated with wide-ranging effects in animal and cellular models, including lifespan extension. To identify the genetic…”
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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition by Wilson, Gemma A, Vuina, Karla, Sava, Georgina, Huard, Caroline, Meneguello, Leticia, Coulombe-Huntington, Jasmin, Bertomeu, Thierry, Maizels, Rory J, Lauring, Josh, Kriston-Vizi, Janos, Tyers, Mike, Ali, Simak, Bertoli, Cosetta, de Bruin, Robertus A M

“…Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene…”
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A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition by Benslimane, Yahya, Sánchez‐Osuna, María, Coulombe‐Huntington, Jasmin, Bertomeu, Thierry, Henry, Danielle, Huard, Caroline, Bonneil, Éric, Thibault, Pierre, Tyers, Mike, Harrington, Lea

“…Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase (TERT), contributes to age‐associated tissue dysfunction and…”
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Targeting PLZF Enhances Glucocorticoid Sensitivity in Acute Myeloid Leukemia by Hajmirza, Azadeh, Simon, Laura, Chagraoui, Jalila, Mayotte, Nadine, Spinella, Jean-François, Macrae, Tara, Lehnertz, Bernhard, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Boucher, Geneviève, Lemieux, Sébastien, Tyers, Mike, Hebert, Josee, Sauvageau, Guy

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Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality by Navare, Arti T, Mast, Fred D, Olivier, Jean Paul, Bertomeu, Thierry, Neal, Maxwell L, Carpp, Lindsay N, Kaushansky, Alexis, Coulombe-Huntington, Jasmin, Tyers, Mike, Aitchison, John D

“…Viruses co-opt host proteins to carry out their lifecycle. Repurposed host proteins may thus become functionally compromised; a situation analogous to a…”
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Abstract C4: TLN-4601 is a novel tumor selective pro-apoptotic agent acting independently of Bax, Bak or Bcl-2 expression by Bertomeu, Thierry, Gourdeau, Henriette

“…Abstract Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered through Thallion's proprietary DECIPHER® technology platform…”
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3082 – EXPLORING GLUCOCORTICOID SENSITIVITY MODULATORS IN HUMAN ACUTE MYELOID LEUKEMIA by Hajmirza, Azadeh, Simon, Laura, Spinella, Jean-François, MacRae, Tara, Lehnertz, Bernhard, Chagraoui, Jalila, Mayotte, Nadine, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Boucher, Geneviève, Feghaly, Albert, Bordeleau, Marie-Eve, Lemieux, Sébastien, Tyers, Mike, Hébert, Josée, Sauvageau, Guy

“…Glucocorticoids (GCs) are widely used in treatment of different kinds of lymphoma and leukemia, such as acute lymphoblastic leukemia. However, why only a…”
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Chemogenomic Approach Unveils the Increased Susceptibility of RUNX1-Mutated AML to Glucocorticoids by Simon, Laura, Lavallee, Vincent-Philippe, Bordeleau, Marie-Eve, Lehnertz, Bernhard, MacRae, Tara, Chagraoui, Jalila, Spinella, Jean-Francois, Boucher, Geneviève, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, Tyers, Mike, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…RUNX1 is an essential transcription factor for definite hematopoiesis and plays important roles in immune function. Mutations in RUNX1 occur in 5-13% of Acute…”
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Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex by St-Cyr, Daniel, Ceccarelli, Derek F, Orlicky, Stephen, van der Sloot, Almer M, Tang, Xiaojing, Kelso, Susan, Moore, Susan, James, Clint, Posternak, Ganna, Coulombe-Huntington, Jasmin, Bertomeu, Thierry, Marinier, Anne, Sicheri, Frank, Tyers, Mike

“…Pharmacological control of the ubiquitin-proteasome system (UPS) is of intense interest in drug discovery. Here, we report the development of chemical…”
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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia by Baccelli, Irene, Gareau, Yves, Lehnertz, Bernhard, Stephane, Gingras, Spinella, Jean-Francois, Beautrait, Alexandre, Corneau, Sophie, Mayotte, Nadine, Boivin, Isabel, Girard, Simon, MacRae, Tara, Frechette, Melanie, Leveille, Koryne, Krosl, Jana, Thiollier, Clarisse, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P, Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…60% to 70% of Acute Myeloid Leukemia (AML) patients enter complete remission after induction regimen, but the majority relapse within 3 years due to the…”
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S-Phase and M-Phase Timing Are under Independent Circadian Control in the Dinoflagellate Lingulodinium by Dagenais-Bellefeuille, Steve, Bertomeu, Thierry, Morse, David

“…In many phytoplankton species, cell division (mitosis) usually occurs at defined times of day. This timing is also observed under constant conditions,…”
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