Search Results - "allen, patrick b."

Ulcerative colitis by Ungaro, Ryan, MD, Mehandru, Saurabh, MD, Allen, Patrick B, MD, Peyrin-Biroulet, Laurent, Prof, Colombel, Jean-Frédéric, Professor

“…Summary Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial,…”
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Postoperative recurrent luminal Crohn's Disease: A systematic review by De Cruz, Peter, Kamm, Michael A., Prideaux, Lani, Allen, Patrick B., Desmond, Paul V.

“…Despite improved immunosuppressive therapy, surgical resection is still often required for uncontrolled inflammatory disease and the stenosing and perforating…”
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Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease by Efthymiou, Marios, Allen, Patrick B, Taylor, Andrew C F, Desmond, Paul V, Jayasakera, Chatura, De Cruz, Peter, Kamm, Michael A

“…Mucosal dye spraying (chromoendoscopy [CE]) has been shown in controlled studies to enhance lesion detection in colitis surveillance. Narrow band imaging (NBI)…”
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Spinophilin Facilitates Dephosphorylation of Doublecortin by PP1 to Mediate Microtubule Bundling at the Axonal Wrist by Bielas, Stephanie L., Serneo, Finley F., Chechlacz, Magdalena, Deerinck, Thomas J., Perkins, Guy A., Allen, Patrick B., Ellisman, Mark H., Gleeson, Joseph G.

“…The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized…”
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Preventing disability in inflammatory bowel disease by Allen, Patrick B., Gower-Rousseau, Corinne, Danese, Silvio, Peyrin-Biroulet, Laurent

“…Disability is a common worldwide health challenge and it has been increasing over the past 3 decades. The treatment paradigm has changed dramatically in…”
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Does anti-TNF therapy reduce the requirement for surgery in ulcerative colitis? A systematic review by Filippi, Jérôme, Allen, Patrick B, Hébuterne, Xavier, Peyrin-Biroulet, Laurent

“…Infliximab has demonstrated its efficacy in moderate to severe ulcerative colitis. The Active Ulcerative Colitis Trial (ACT) -1 and 2 have demonstrated the…”
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Estrogen Alters Hippocampal Dendritic Spine Shape and Enhances Synaptic Protein Immunoreactivity and Spatial Memory in Female Mice by Li, Chenjian, Brake, Wayne G., Romeo, Russell D., Dunlop, John C., Gordon, Marisa, Buzescu, Rodica, Magarinos, Ana Maria, Allen, Patrick B., Greengard, Paul, Luine, Victoria, McEwen, Bruce S.

“…Estrogen (E) treatment induces axospinous synapses in rat hippocampus in vivo and in cultured hippocampal neurons in vitro. To better explore the molecular…”
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NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study by Germain, Adeline, MD, Guéant, Rosa-Maria, MD, PhD, Chamaillard, Mathias, PhD, Allen, Patrick B., MD, Bresler, Laurent, MD, Guéant, Jean-Louis, MD, PhD, Peyrin-Biroulet, Laurent, MD, PhD

“…Background Postoperative complications are relatively frequent in Crohn's disease (CD) and several risk factors have been identified. The influence of genetic…”
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Anti-adhesion molecules: is gut specificity the key for a good safety profile? by Allen, Patrick B

“…Inflammatory bowel diseases (IBD) are chronic relapsing and remitting disorders that have varying degrees of severity. However multiple studies have confirmed…”
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Adrenergic Modulation of NMDA Receptors in Prefrontal Cortex Is Differentially Regulated by RGS Proteins and Spinophilin by Liu, Wenhua, Yuen, Eunice Y., Allen, Patrick B., Feng, Jian, Greengard, Paul, Yan, Zhen

“…The noradrenergic system in the prefrontal cortex (PFC) is involved in many physiological and psychological processes, including working memory and mood…”
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Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function by Charlton, Joanna J., Allen, Patrick B., Psifogeorgou, Kassi, Chakravarty, Sumana, Gomes, Ivone, Neve, Rachael L., Devi, Lakshmi A., Greengard, Paul, Nestler, Eric J., Zachariou, Venetia

“…Spinophilin, a dendritic spine-enriched scaffold protein, modulates synaptic transmission via multiple functions mediated by distinct domains of the protein…”
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Phactrs 1-4: A Family of Protein Phosphatase 1 and Actin Regulatory Proteins by Allen, Patrick B., Greenfield, Audrey T., Svenningsson, Per, Haspeslagh, Derek C., Greengard, Paul

“…Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic…”
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Spinophilin Blocks Arrestin Actions In vitro and In vivo at G Protein-Coupled Receptors by Wang, Qin, Zhao, Jiali, Brady, Ashley E., Feng, Jian, Allen, Patrick B., Lefkowitz, Robert J., Greengard, Paul, Limbird, Lee E.

“…Arrestin regulates almost all G protein-coupled receptor (GPCR)-mediated signaling and trafficking. We report that the multidomain protein, spinophilin,…”
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Spinophilin, a Novel Protein Phosphatase 1 Binding Protein Localized to Dendritic Spines by Allen, Patrick B., Ouimet, Charles C., Greengard, Paul

“…Dendritic spines receive the vast majority of excitatory synaptic contacts in the mammalian brain and are presumed to contain machinery for the integration of…”
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How do patients with inflammatory bowel disease want their biological therapy administered? by Allen, Patrick B, Lindsay, Hannah, Tham, Tony C K

“…Infliximab is usually administered by two monthly intravenous (iv) infusions, therefore requiring visits to hospital. Adalimumab is administered by self…”
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UK clinical experience up to 52 weeks with linaclotide for irritable bowel syndrome with constipation by Yiannakou, Yan, Agrawal, Anu, Allen, Patrick B., Arebi, Naila, Brown, Steven R., Eugenicos, Maria P., Farmer, Adam D., McLain-Smith, Su, McLaughlin, John, Sanders, David S., Lawrance, Dominic, Emmanuel, Anton

“…Background: Linaclotide, a guanylate cyclase C agonist, has been shown in clinical trials to improve symptoms of irritable bowel syndrome with constipation…”
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Type 1 Phosphatase, a Negative Regulator of Cardiac Function by Carr, Andrew N., Schmidt, Albrecht G., Suzuki, Yoichi, del Monte, Federica, Sato, Yoji, Lanner, Carita, Breeden, Kristine, Jing, Shao-Ling, Allen, Patrick B., Greengard, Paul, Yatani, Atsuko, Hoit, Brian D., Grupp, Ingrid L., Hajjar, Roger J., DePaoli-Roach, Anna A., Kranias, Evangelia G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Noninvasive imaging of the small bowel in Crohn's disease: The final frontier by Allen, Patrick B., De Cruz, Peter, Lee, Wai Kit, Taylor, Stuart, Desmond, Paul V., Kamm, Michael A.

“…The substantial morbidity and mortality associated with Crohn's disease underlines the importance of accurate assessment at presentation, during follow‐up,…”
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Nicorandil Associated Colonic Ulceration: Case Series of an Increasingly Recognized Complication by Lee, Bee C., Allen, Patrick B., Caddy, Grant R., Mainie, Inder

“…Background Nicorandil is widely accepted in the therapeutic armamentarium of ischemic heart disease and, although nicorandil-induced oral and anal ulcerations…”
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Assessing disease control in inflammatory bowel disease: a real world cross-sectional study in the UK (PODCAST-IBD) by de Silva, Shanika, Steed, Helen, Allen, Patrick B, Vegad, Chirag, Crooks, James, Jaulim, Adil, Hart, Ailsa

“…Proportion Of suboptimal Disease Control And Strategy of Treatment in IBD (PODCAST-IBD) was an international real-world study which aimed to quantify disease…”
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