Search Results - "af Hallstrom, Taija M"

Circulating tumor DNA in early‐stage breast cancer: personalized biomarkers for occult metastatic disease and risk of relapse? by af Hällström, Taija M, Puhka, Maija, Kallioniemi, Olli

“…The availability of blood‐based markers to predict response of a solid tumor to treatment, estimate patient prognosis and diagnose relapse well before clinical…”
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DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue by JÄÄMAA, Sari, AF HÄLLSTRÖM, Taija M, RUUTU, Mirja, ANDERSSON, Leif C, LAIHO, Marikki, SANKILA, Anna, RANTANEN, Ville, KOISTINEN, Hannu, STENMAN, Ulf-Håkan, ZHEWEI ZHANG, ZHIMING YANG, DE MARZO, Angelo M, TAARI, Kimmo

“…DNA damage response (DDR) pathways have been extensively studied in cancer cell lines and mouse models, but little is known about how DNA damage is recognized…”
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Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents by Peltonen, Karita, Colis, Laureen, Liu, Hester, Jäämaa, Sari, Moore, Henna M, Enbäck, Juulia, Laakkonen, Pirjo, Vaahtokari, Anne, Jones, Richard J, af Hällström, Taija M, Laiho, Marikki

“…Manipulation of the activity of the p53 tumor suppressor pathway has demonstrated potential benefit in preclinical mouse tumor models and has entered human…”
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Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement by Kiviharju-af Hällström, Taija M, Jäämaa, Sari, Mönkkönen, Mia, Peltonen, Karita, Andersson, Leif C, Medema, René H, Peehl, Donna M, Laiho, Marikki

“…Cellular DNA damage triggers the DNA damage response pathway and leads to enforcement of cell cycle checkpoints, which are essential for the maintenance of…”
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Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture by Zhang, Zhewei, Yang, Zhiming, Jäämaa, Sari, Liu, Hester, Pellakuru, Laxmi G., Iwata, Tsuyoshi, af Hällström, Taija M., De Marzo, Angelo M., Laiho, Marikki

“…The ability of cells to respond and repair DNA damage is fundamental for the maintenance of genomic integrity. Ex vivo culturing of surgery-derived human…”
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Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer by Saeed, Khalid, Rahkama, Vesa, Eldfors, Samuli, Bychkov, Dmitry, Mpindi, John Patrick, Yadav, Bhagwan, Paavolainen, Lassi, Aittokallio, Tero, Heckman, Caroline, Wennerberg, Krister, Peehl, Donna M, Horvath, Peter, Mirtti, Tuomas, Rannikko, Antti, Kallioniemi, Olli, Östling, Päivi, af Hällström, Taija M

“…Abstract Background Technology development to enable the culture of human prostate cancer (PCa) progenitor cells is required for the identification of new,…”
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Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices by Davies, Emma J., Dong, Meng, Gutekunst, Matthias, Närhi, Katja, van Zoggel, Hanneke J. A. A., Blom, Sami, Nagaraj, Ashwini, Metsalu, Tauno, Oswald, Eva, Erkens-Schulze, Sigrun, Delgado San Martin, Juan A., Turkki, Riku, Wedge, Stephen R., af Hällström, Taija M., Schueler, Julia, van Weerden, Wytske M., Verschuren, Emmy W., Barry, Simon T., van der Kuip, Heiko, Hickman, John A.

“…Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment…”
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Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient‐derived cancer cells by Saeed, Khalid, Ojamies, Poojitha, Pellinen, Teijo, Eldfors, Samuli, Turkki, Riku, Lundin, Johan, Järvinen, Petrus, Nisen, Harry, Taari, Kimmo, af Hällström, Taija M., Rannikko, Antti, Mirtti, Tuomas, Kallioniemi, Olli, Östling, Päivi

“…Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is…”
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Genetic changes and DNA damage responses in the prostate by Kiviharju-af Hällström, Taija M., Laiho, Marikki

“…The integrity of genomic DNA is challenged by genotoxic stress originating during normal cellular metabolism or by external insults. Cellular responses to DNA…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Närhi, Katja, Nagaraj, Ashwini S, Parri, Elina, Turkki, Riku, van Duijn, Petra W, Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I, Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M, Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W

“…A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial…”
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PSA forms complexes with α1-antichymotrypsin in prostate by Zhu, Lei, Jäämaa, Sari, af Hällström, Taija M., Laiho, Marikki, Sankila, Anna, Nordling, Stig, Stenman, Ulf-Håkan, Koistinen, Hannu

“…BACKGROUND PSA is the most useful prostate cancer marker. However, its levels are increased also in some non‐malignant conditions. In circulation, the majority…”
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A tissue graft model of DNA damage response in the normal and malignant human prostate by Af Hällström, Taija M, Zhao, Hongjuan, Tian, Junqiang, Rantanen, Ville, Reese, Stephen W, Nolley, Rosalie, Laiho, Marikki, Peehl, Donna M

“…DNA damage responses are relevant to prostate cancer initiation, progression and treatment. Few models of the normal and malignant human prostate that maintain…”
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Contrasting DNA damage checkpoint responses in epithelium of the human seminal vesicle and prostate by Jäämaa, Sari, Sankila, Anna, Rantanen, Ville, Peltonen, Karita, Järvinen, Päivi M., af Hällström, Taija M., Ruutu, Mirja, Taari, Kimmo, Andersson, Leif C., Laiho, Marikki

“…BACKGROUND Prostate and seminal vesicle are two similar hormone responsive human organs that differ dramatically in their cancer incidence. DNA damage response…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Narhi, K, Nagaraj, AS, Parri, E, Turkki, R, van Duijn, PW, Hemmes, A, Lahtela, J, Uotinen, V, Mayranpaa, MI, Salmenkivi, K, Rasanen, J, Linder, N, Trapman, J, Rannikko, A, Kallioniemi, O, Af Hallstrom, TM, Lundin, J, Sommergruber, W, Anders, S, Verschuren, EW

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PSA forms complexes with [alpha]1-antichymotrypsin in prostate by Zhu, Lei, Jaamaa, Sari, af Hallstrom, Taija M, Laiho, Marikki, Sankila, Anna, Nordling, Stig, Stenman, Ulf-Håkan, Koistinen, Hannu

“…BACKGROUND PSA is the most useful prostate cancer marker. However, its levels are increased also in some non-malignant conditions. In circulation, the majority…”
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PSA forms complexes with α 1 ‐antichymotrypsin in prostate by Zhu, Lei, Jäämaa, Sari, af Hällström, Taija M., Laiho, Marikki, Sankila, Anna, Nordling, Stig, Stenman, Ulf‐Håkan, Koistinen, Hannu

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Abstract 626: DNA damage responses in different cell types of nonproliferating human prostate tissue by af Hällström, Taija M., Jäämaa, Sari, Sankila, Anna, Mirtti, Tuomas, Rantanen, Ville, Koistinen, Hannu, Stenman, Ulf-Håkan, Zhang, Zhewei, Yang, Zhiming, De Marzo, Angelo M., Taari, Kimmo, Ruutu, Mirja, Andersson, Leif C., Laiho, Marikki

“…DNA damage response (DDR) pathways have been extensively studied in cancer cell lines and mouse models, but little is known about how DNA damage is recognized…”
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