Search Results - "abdelgawad, Mohamed A."

Recent Advances of Chitosan Formulations in Biomedical Applications by Abourehab, Mohammed A. S., Pramanik, Sheersha, Abdelgawad, Mohamed A., Abualsoud, Bassam M., Kadi, Ammar, Ansari, Mohammad Javed, Deepak, A.

“…Chitosan, a naturally abundant cationic polymer, is chemically composed of cellulose-based biopolymers derived by deacetylating chitin. It offers several…”
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Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges by Elmowafy, Mohammed, Shalaby, Khaled, Elkomy, Mohammed H, Alsaidan, Omar Awad, Gomaa, Hesham A M, Abdelgawad, Mohamed A, Mostafa, Ehab M

“…In the last few decades, several natural bioactive agents have been widely utilized in the treatment and prevention of many diseases owing to their unique and…”
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Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents by Abdelgawad, Mohamed A., Bakr, Rania B., Omar, Hany A.

“…[Display omitted] •A series of substituted pyrazoles10a-c, 11a-c and 12a- was designed and prepared.•All the candidates…”
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Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors by Sudevan, Sachithra Thazhathuveedu, Oh, Jong Min, Abdelgawad, Mohamed A., Abourehab, Mohammed A. S., Rangarajan, T. M., Kumar, Sunil, Ahmad, Iqrar, Patel, Harun, Kim, Hoon, Mathew, Bijo

“…The inhibitory action of fifteen benzyloxy ortho / para -substituted chalcones ( B1-B15 ) was evaluated against human monoamine oxidases (hMAOs). All the…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors by Kumar, Sunil, Bhowmik, Ratul, Oh, Jong Min, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., Al‑Serwi, Rasha Hamed, Kim, Hoon, Mathew, Bijo

“…Monoamine oxidases (MAOs), specifically MAO-A and MAO-B, play important roles in the breakdown of monoamine neurotransmitters. Therefore, MAO inhibitors are…”
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Review of the Recent Advances in Electrospun Nanofibers Applications in Water Purification by Nayl, AbdElAziz A, Abd-Elhamid, Ahmed I, Awwad, Nasser S, Abdelgawad, Mohamed A, Wu, Jinglei, Mo, Xiumei, Gomha, Sobhi M, Aly, Ashraf A, Bräse, Stefan

“…Recently, nanofibers have come to be considered one of the sustainable routes with enormous applicability in different fields, such as wastewater treatment…”
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Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol by Shahbaz, Muhammad, Imran, Muhammad, Alsagaby, Suliman A., Naeem, Hammad, Al Abdulmonem, Waleed, Hussain, Muzzamal, Abdelgawad, Mohamed A., El-Ghorab, Ahmed H., Ghoneim, Mohammed M., El-Sherbiny, Mohamed, Atoki, Ayomide Victor, Awuchi, Chinaza Godswill

“…Kaempferol, found in various plants and foods, has gained attention as a useful flavonoid owing to its potential biological properties, including anticancer…”
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Biological investigation of N -methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors by D'Agostino, Ilaria, Mathew, Githa Elizabeth, Angelini, Paola, Venanzoni, Roberto, Angeles Flores, Giancarlo, Angeli, Andrea, Carradori, Simone, Marinacci, Beatrice, Menghini, Luigi, Abdelgawad, Mohamed A, Ghoneim, Mohammed M, Mathew, Bijo, Supuran, Claudiu T

“…The enormous burden of the COVID-19 pandemic in economic and healthcare terms has cast a shadow on the serious threat of antimicrobial resistance, increasing…”
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Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations by Sasidharan, Rani, Eom, Bo Hyun, Heo, Jeong Hyun, Park, Jong Eun, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Manju, Sreedharannair Leelabaiamma, Mathew, Bijo, Kim, Hoon

“…Nine compounds (MO1-MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and…”
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Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors by Alagöz, Mehmet Abdullah, Oh, Jong Min, Zenni, Yaren Nur, Özdemir, Zeynep, Abdelgawad, Mohamed A., Naguib, Ibrahim A., Ghoneim, Mohammed M., Gambacorta, Nicola, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo

“…Sixteen compounds (TR1–TR16) were synthesized and evaluated for their inhibitory activities against monoamine oxidase A and B (MAOs). Most of the derivatives…”
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Phenylpyrazolone-1,2,3-triazole Hybrids as Potent Antiviral Agents with Promising SARS-CoV-2 Main Protease Inhibition Potential by Musa, Arafa, Abulkhair, Hamada S, Aljuhani, Ateyatallah, Rezki, Nadjet, Abdelgawad, Mohamed A, Shalaby, Khaled, El-Ghorab, Ahmed H, Aouad, Mohamed R

“…COVID-19 infection is now considered one of the leading causes of human death. As an attempt towards the discovery of novel medications for the COVID-19…”
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Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies by Abdelgawad, Mohamed A., Labib, Madlen B., Ali, Waleed A.M., Kamel, Gehan, Azouz, Amany A., EL-Nahass, EL-Shaymaa

“…[Display omitted] •Compounds 5d, 5f and 5i were found to be the most potent COX-2/5-LOX inhibitors with superior COX-2 selectivity index.•Four compounds; 5b,…”
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Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms by Abo El-Enin, Hadel A, Mostafa, Rasha E, Ahmed, Marwa F, Naguib, Ibrahim A, A Abdelgawad, Mohamed, Ghoneim, Mohammed M, Abdou, Ebtsam M

“…Migraine is one of the major symptoms of many psychiatric and mental disorders like depression and anxiety. Eletriptan Hydrobromide (EH) is a well-tolerated…”
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Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks by Philoppes, John N., Abdelgawad, Mohamed A., Abourehab, Mohammed A. S., Sebak, Mohamed, A. Darwish, Mostafa, Lamie, Phoebe F.

“…Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a-e, and 5a-e were synthesised. Different biological activities of the synthesised compounds…”
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Cytotoxic and Antioxidant Potential of Launaea mucronata Forssk Essential Oil Growing in Northern Saudi Arabia by Mostafa, Ehab M., El-Ghorab, Ahmed H., Ghoneim, Mohammed M., Ebrahim, Hasnaa Ali, Abulfaraj, Moaz, Abdelgawad, Mohamed A., Farouk, Amr, Musa, Arafa

“…Essential oils are naturally occurring multicomponent combinations of isoprenoids with distinctive odors that are produced by aromatic plants from mevalonic…”
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A Comprehensive Review of the Docking Studies of Chalcone for the Development of Selective MAO-B Inhibitors by Krishna, Athulya, Kumar, Sunil, Sudevan, Sachithra Thazhathuveedu, Singh, Ashutosh Kumar, Pappachen, Leena K, Rangarajan, T M, Abdelgawad, Mohamed A, Mathew, Bijo

“…Monoamine oxidase B is a crucial therapeutic target for neurodegenerative disorders like Alzheimer's and Parkinson's since they assist in disintegrating…”
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Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease by Manoharan, Amritha, Oh, Jong Min, Benny, Feba, Kumar, Sunil, Abdelgawad, Mohamed A, Ghoneim, Mohammed M, Shaker, Mohamed E, El-Sherbiny, Mohamed, Almohaimeed, Hailah M, Gahtori, Prashant, Kim, Hoon, Mathew, Bijo

“…Monoamine oxidase (MAO, EC 1.4.3.4) is responsible for the oxidative breakdown of both endogenous and exogenous amines and exists in MAO-A and MAO-B isomers…”
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Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold by Abdelgawad, Mohamed A, Hayallah, Alaa M, Bukhari, Syed Nasir Abbas, Musa, Arafa, Elmowafy, Mohammed, Abdel-Rahman, Hamdy M, Abd El-Gaber, Mohammed K

“…A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors…”
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Investigation of Chemical Compositions and Biological Activities of Mentha suaveolens L. from Saudi Arabia by Aldogman, Bashayr, Bilel, Hallouma, Moustafa, Shaima Mohamed Nabil, Elmassary, Khaled F, Ali, Hazim M, Alotaibi, Faddaa Qayid, Hamza, Mohamed, Abdelgawad, Mohamed A, El-Ghorab, Ahmed H

“…is an aromatic plant used since antiquity for its pharmaceutical virtues. The climate of Saudi Arabia favors the growth of aromatic plants including L. The aim…”
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