Search Results - "Zydowsky, T M"

The Nonnucleoside Reverse Transcriptase Inhibitor MIV-150 in Carrageenan Gel Prevents Rectal Transmission of Simian/Human Immunodeficiency Virus Infection in Macaques by SINGER, R, DERBY, N, PIATAK, M, FERNANDEZ-ROMERO, J. A, ZYDOWSKY, T. M, ROBBIANI, M, RODRIGUEZ, A, KIZIMA, L, KENNEY, J, ARAVANTINOU, M, CHUDOLIJ, A, GETTIE, A, BLANCHARD, J, LIFSON, J. D

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Discovery of a novel class of orally active, non-peptide angiotensin II antagonists by De, B, Winn, M, Zydowsky, T. M, Kerkman, D. J, DeBernardis, J. F, Lee, J, Buckner, S, Warner, R, Brune, M

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Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat by Lee, J Y, Buckner, S A, Brune, M E, Warner, R B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, Debernardis, J F

“…2-(N-Propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl-4yl)methyl]amin o) pyridine-3-carboxylic acid (ABBOTT-81988), a novel nonpeptide angiotensin II (AII) antagonist,…”
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Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B by Zydowsky, T. M, Courtney, L. F, Frasca, V, Kobayashi, K, Shimizu, H, Yuen, L. D, Matthews, R. G, Benkovic, S. J, Floss, H. G

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Stereochemical course of methyl transfer from methanol to methyl coenzyme M in cell-free extracts of Methanosarcina barkeri by Zydowsky, L. D, Zydowsky, T. M, Haas, E. S, Brown, J. W, Reeve, J. N, Floss, Heinz G

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Antihypertensive activity of ABBOTT-81282, a nonpeptide angiotensin II antagonist, in the renal hypertensive rat by Lee, J Y, Brune, M E, Warner, R B, Buckner, S B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81282, 4-(N-butyl-N-[(2-'-[1H-tetrazol-5yl]biphenyl-4-yl)methyl]ami no) pyrimidine-5-carboxylic acid is a novel nonpeptide angiotensin II (AII)…”
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Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors by Hancock, A A, Buckner, S A, Lee, J Y, Brune, M, Morse, P A, Oheim, K, Warner, R B, Winn, M, Zydowsky, T M, De, B

“…Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At…”
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Cardiovascular effects of orally administered ABBOTT-81988, an angiotensin II antagonist, in conscious spontaneously hypertensive rats by Lee, J Y, Warner, R B, Brune, M E, Adler, A L, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81988 (A-81988), 2-(N-propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl- 4yl)methyl] amino) pyridine-3-carboxylic acid, a nonpeptide angiotensin II (AII)…”
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A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use by Kenney, Jessica, Singer, Rachel, Derby, Nina, Aravantinou, Meropi, Abraham, Ciby J, Menon, Radhika, Seidor, Samantha, Zhang, Shimin, Gettie, Agegnehu, Blanchard, James, Piatak, Jr, Michael, Lifson, Jeffrey D, Fernández-Romero, José A, Zydowsky, Thomas M, Robbiani, Melissa

“…Previously we showed that repeated vaginal application of a MIV-150/zinc acetate carrageenan (MIV-150/ZA/CG) gel and a zinc acetate carrageenan (ZA/CG) gel…”
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Stereochemistry of the in Vitro and in Vivo Methylation of DNA by (R)- and (S)-N-[2H1,3H]Methyl-N-nitrosourea and (R)- and (S)-N-Nitroso-N-[2H1,3H]methyl- N-methylamine by Spratt, Thomas E, Zydowsky, Thomas M, Floss, Heinz G

“…Reaction of DNA with the carcinogens N-methyl-N-nitrosourea and N-nitroso-N,N-dimethylamine produces several methylated species including the premutagenic O…”
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2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists by Winn, Martin, De, Biswanath, Zydowsky, Thomas M, Altenbach, Robert J, Basha, Fatima Z, Boyd, Steven A, Brune, Michael E, Buckner, Steven A, Crowell, DeAnne

“…A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a -CH2-NR'-link (1) were discovered to be potent…”
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Sterochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B by ZYDOWSKY, T. M, COURTNEY, L. F, FRASCA, V, KOBAYASHI, K, SHIMIZU, H, YUEN, L.-D, MATTHEWS, R. G, BENKOVIC, S. J, FLOSS, H. G

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Receptor interactions of Abbott-81988, a highly potent, non-peptide angiotensin-II antagonist selective for type-1 receptors by Hancock, A A, Buckner, S A, Lee, J Y, Brune, M, Morse, P A, Oheim, K, Warner, R B, Winn, M, Zydowsky, T M, De, B

“…Abbott-81988 (A-81988) was selected from a series of related compounds as a highly potent and selective antagonist of angiotensin receptors. In the rabbit…”
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A simple and efficient synthesis of chiral acetic acid of high optical purity by Kobayashi, Koji, Jadhav, Prabhakar K, Zydowsky, Thomas M, Floss, Heinz G

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Preparation of chirally deuterated N-(trifluoroacetyl)-.beta.-alanine and related compounds by Hill, Richard K, Prakash, Shimoga R, Zydowsky, Thomas M

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Efficient and versatile synthesis of dipeptide isosteres containing .gamma.- or .delta.-lactams by Zydowsky, Thomas M, Dellaria, Joseph F, Nellans, Hugh N

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Direct oxygenation of enolates generated by anionic oxy-Cope rearrangement. Expedient preparation of polycyclic .alpha.-hydroxy ketones by Paquette, Leo A, DeRussy, Donald T, Pegg, Neil A, Taylor, Richard T, Zydowsky, Thomas M

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Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 1. A Solution to the Problem of Chirality Merger during Elaboration of the Entire Carbotricyclic Framework by Paquette, Leo A, Nakatani, Shogo, Zydowsky, Thomas M, Edmondson, Scott D, Sun, Li-Qiang, Skerlj, Renato

“…A practical route for elaboration of the [5.9.5] tricyclic nucleus of jatrophatrione (1) is reported. The two key steps involve an oxyanionic Cope…”
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Stereoselective synthesis of α-alkyl α-amino acids. Alkylation of 3-substituted 5H,10bH-oxazolo[3,2-c][1,3]benzoxazine-2,3(3H),5-diones by ZYDOWSKY, T. M, DE LARA, E, SPANTON, S. G

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Discovery of a novel class of orally active, non-peptide angiotensin II antogonists by DE, B, WINN, M, OPGENORTH, T, MARSH, K, ZYDOWSKY, T. M, KERKMAN, D. J, DEBERNARDIS, J. F, LEE, L, BUCKNER, S, WARNER, R, BRUNE, M, HANCOCK, A

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