Search Results - "Zwijsen, An"
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Bone Morphogenetic Proteins in Vascular Homeostasis and Disease
Published in Cold Spring Harbor perspectives in biology (01-02-2018)“…It is well established that control of vascular morphogenesis and homeostasis is regulated by vascular endothelial growth factor (VEGF), fibroblast growth…”
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Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor‐dependent signaling pathways balance stalk vs. tip cell competence
Published in The FASEB journal (01-11-2017)“…Before the onset of sprouting angiogenesis, the endothelium is prepatterned for the positioning of tip and stalk cells. Both cell identities are not static, as…”
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Author Correction: The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay
Published in Scientific reports (31-03-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay
Published in Scientific reports (16-03-2018)“…Atrioventricular septal defects often result from impaired endocardial cushion development. Endothelial-to-mesenchymal transition (EndoMT) is a critical event…”
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Lineage-specific functions of TET1 in the postimplantation mouse embryo
Published in Nature genetics (01-07-2017)“…Kian Peng Koh and colleagues report that TET1 regulates lineage-specific genes in the mouse postimplantation embryo, many of them independently of DNA…”
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Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination
Published in Nature neuroscience (01-08-2016)“…This study shows that the transcriptional regulator Zeb2 is required for the onset of peripheral myelination and remyelination. Zeb2 recruits HDAC1–HDAC2–NuRD…”
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The development of the amnion in mice and other amniotes
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-12-2022)“…The amnion is an extraembryonic tissue that evolutionarily allowed embryos of all amniotes to develop in a transient and local aquatic environment. Despite the…”
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Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis
Published in Neurobiology of disease (01-11-2018)“…Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affecting motor neurons. Motor neuron degeneration is accompanied…”
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The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology
Published in International journal of molecular sciences (14-06-2021)“…Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent…”
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Keratin filaments mediate the expansion of extra‐embryonic membranes in the post‐gastrulation mouse embryo
Published in The EMBO journal (04-04-2022)“…Mesoderm arises at gastrulation and contributes to both the mouse embryo proper and its extra‐embryonic membranes. Two‐photon live imaging of embryos bearing a…”
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The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency
Published in Nature communications (03-03-2023)“…Early during preimplantation development and in heterogeneous mouse embryonic stem cells (mESC) culture, pluripotent cells are specified towards either the…”
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Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function
Published in Circulation research (25-06-2021)“…[Figure: see text]…”
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BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development
Published in Biomolecules (Basel, Switzerland) (23-03-2020)“…Vascular development is an orchestrated process of vessel formation from pre-existing vessels via sprouting and intussusceptive angiogenesis as well as…”
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On the origin of amniotic stem cells: of mice and men
Published in The International journal of developmental biology (2010)“…A common characteristic of mammals is the development of extraembryonic supporting tissues and organs that are required for embryonic implantation, survival…”
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EGFL7 Mediates BMP9-Induced Sprouting Angiogenesis of Endothelial Cells Derived from Human Embryonic Stem Cells
Published in Stem cell reports (11-06-2019)“…Human embryonic stem cells (hESCs) are instrumental in characterizing the molecular mechanisms of human vascular development and disease. Bone morphogenetic…”
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Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling
Published in Development (Cambridge) (01-07-2018)“…Upon gastrulation, the mammalian conceptus transforms rapidly from a simple bilayer into a multilayered embryo enveloped by its extra-embryonic membranes…”
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Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice
Published in Molecular and Cellular Biology (01-01-2008)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression
Published in Blood (31-01-2013)“…Although it is well established that BMP4 plays an important role in the development of hematopoietic system, it is less well understood whether BMP4 affects…”
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Endothelial SMAD1/5 signaling couples angiogenesis to osteogenesis in juvenile bone
Published in Communications biology (13-03-2024)“…Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone formation in part by activating SMAD1/5…”
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Transforming Growth Factor type β and Smad family signaling in stem cell function
Published in Cytokine & growth factor reviews (01-10-2009)“…Abstract Ligands of the Transforming Growth Factor type β (TGFβ) family exert multiple and sometimes opposite effects on most cell types in vivo depending on…”
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