Search Results - "Zwier, Jurriaan M."

new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors by Doumazane, Etienne, Scholler, Pauline, Zwier, Jurriaan M, Eric, Trinquet, Rondard, Philippe, Pin, Jean-Philippe

“…G-protein-coupled receptors (GPCRs) can form heteromeric complexes. Herein, we describe a new approach to test the heteromerization of 2 receptors, or 2…”
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Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors by Doumazane, Etienne, Scholler, Pauline, Fabre, Ludovic, Zwier, Jurriaan M., Trinquet, Eric, Pin, Jean-Philippe, Rondard, Philippe

“…In multimeric cell-surface receptors, the conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor activation remain…”
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Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy by Rahmeh, Rita, Damian, Marjorie, Cottet, Martin, Orcel, Hélène, Mendre, Christiane, Durroux, Thierry, Sharma, K. Shivaji, Durand, Grégory, Pucci, Bernard, Trinquet, Eric, Zwier, Jurriaan M, Deupi, Xavier, Bron, Patrick, Banères, Jean-Louis, Mouillac, Bernard, Granier, Sébastien

“…G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate most cellular responses to hormones and neurotransmitters, representing the…”
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Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy by Olofsson, Linnea, Felekyan, Suren, Doumazane, Etienne, Scholler, Pauline, Fabre, Ludovic, Zwier, Jurriaan M., Rondard, Philippe, Seidel, Claus A. M., Pin, Jean-Philippe, Margeat, Emmanuel

“…Efficient cell-to-cell communication relies on the accurate signalling of cell surface receptors. Understanding the molecular bases of their activation…”
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Comparative Analysis of Conjugated Alkynyl Chromophore-Triazacyclononane Ligands for Sensitized Emission of Europium and Terbium by Soulié, Marine, Latzko, Frédéric, Bourrier, Emmanuel, Placide, Virginie, Butler, Stephen J., Pal, Robert, Walton, James W., Baldeck , Patrice L., Le Guennic, Boris, Andraud, Chantal, Zwier, Jurriaan M., Lamarque, Laurent, Parker, David, Maury, Olivier

“…A series of europium and terbium complexes based on a functionalized triazacyclononane carboxylate or phosphinate macrocyclic ligand is described. The…”
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Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells by Moreno Delgado, David, Møller, Thor C, Ster, Jeanne, Giraldo, Jesús, Maurel, Damien, Rovira, Xavier, Scholler, Pauline, Zwier, Jurriaan M, Perroy, Julie, Durroux, Thierry, Trinquet, Eric, Prezeau, Laurent, Rondard, Philippe, Pin, Jean-Philippe

“…Metabotropic glutamate receptors (mGluRs) are mandatory dimers playing important roles in regulating CNS function. Although assumed to form exclusive…”
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Bright, Highly Water-Soluble Triazacyclononane Europium Complexes To Detect Ligand Binding with Time-Resolved FRET Microscopy by Delbianco, Martina, Sadovnikova, Victoria, Bourrier, Emmanuel, Mathis, Gérard, Lamarque, Laurent, Zwier, Jurriaan M., Parker, David

“…Luminescent europium complexes are used in a broad range of applications as a result of their particular emissive properties. The synthesis and application of…”
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Synthesis and Evaluation of Europium Complexes that Switch on Luminescence in Lysosomes of Living Cells by Starck, Matthieu, Fradgley, Jack D., Pal, Robert, Zwier, Jurriaan M., Lamarque, Laurent, Parker, David

“…A set of four luminescent EuIII complexes bearing an extended aryl‐alkynylpyridine chromophore has been studied, showing very different pH‐dependent behaviour…”
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Luminescent Lanthanide Cryptates: from the Bench to the Bedside by Zwier, Jurriaan M, Bazin, Hervé, Lamarque, Laurent, Mathis, Gérard

“…The design and application of luminescent lanthanide cryptates for sensing biological interactions is highlighted through the review of the work performed in…”
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Photoinduced Intramolecular Electron Transfer in a Bridged C60 (Acceptor)-Aniline (Donor) System; Photophysical Properties of the First "Active" Fullerene Diad by Williams, Rene M, Zwier, Jurriaan M, Verhoeven, Jan W

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Design of novel tripyridinophane-based Eu(III) complexes as efficient luminescent labels for bioassay applications by Leygue, Nadine, Picard, Claude, Faure, Pamela, Bourrier, Emmanuel, Lamarque, Laurent, Zwier, Jurriaan M, Galaup, Chantal

“…In this work, the development of highly luminescent europium(III) complexes in water solution is reported, including their syntheses, analyses of their…”
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EuroTracker® dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging by Butler, Stephen J, Delbianco, Martina, Lamarque, Laurent, McMahon, Brian K, Neil, Emily R, Pal, Robert, Parker, David, Walton, James W, Zwier, Jurriaan M

“…The development of the brightest luminescent europium(iii) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized…”
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Single‐Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots by Chen, Chi, Ao, Lijiao, Wu, Yu‐Tang, Cifliku, Vjona, Cardoso Dos Santos, Marcelina, Bourrier, Emmanuel, Delbianco, Martina, Parker, David, Zwier, Jurriaan M., Huang, Liang, Hildebrandt, Niko

“…Fluorescence barcoding based on nanoparticles provides many advantages for multiparameter imaging. However, creating different concentration‐independent codes…”
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Original Fluorescent Ligand-Based Assays Open New Perspectives in G-Protein Coupled Receptor Drug Screening by Cottet, Martin, Faklaris, Orestis, Zwier, Jurriaan M., Trinquet, Eric, Pin, Jean-Philippe, Durroux, Thierry

“…The identification of new drugs exhibiting reduced adverse side-effects constitutes a great challenge for the next decade. Various steps are needed to screen…”
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Different EGF‐induced receptor dimer conformations for signaling and internalization by Haubrich, Jordi, Zwier, Jurriaan M., Charrier‐Savournin, Fabienne, Prézeau, Laurent, Pin, Jean‐Philippe

“…The structural basis of the activation and internalization of EGF receptors (EGFR) is still a matter of debate despite the importance of this target in cancer…”
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FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABA B Receptor by Lecat-Guillet, Nathalie, Monnier, Carine, Rovira, Xavier, Kniazeff, Julie, Lamarque, Laurent, Zwier, Jurriaan M, Trinquet, Eric, Pin, Jean-Philippe, Rondard, Philippe

“…The main inhibitory neurotransmitter, γ-aminobutyric acid (GABA), modulates many synapses by activating the G protein-coupled receptor GABA , which is a target…”
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Very bright europium complexes that stain cellular mitochondria by Walton, James W, Bourdolle, Adrien, Butler, Stephen J, Soulie, Marine, Delbianco, Martina, McMahon, Brian K, Pal, Robert, Puschmann, Horst, Zwier, Jurriaan M, Lamarque, Laurent, Maury, Olivier, Andraud, Chantal, Parker, David

“…The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by…”
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Time-Resolved Förster Resonance Energy Transfer-Based Technologies to Investigate G Protein-Coupled Receptor Machinery: High-Throughput Screening Assays and Future Development by Prézeau, Laurent, Scholler, Pauline, Trinquet, Eric, Pin, Jean-Philippe, Kniazeff, Julie, M. Zwier, Jurriaan, Rondard, Philippe

“…High-throughput screening requires easy-to-monitor, rapid, robust, reliable, and miniaturized methods to test thousands of compounds on a target in a short…”
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation by Scholler, Pauline, Moreno-Delgado, David, Lecat-Guillet, Nathalie, Doumazane, Etienne, Monnier, Carine, Charrier-Savournin, Fabienne, Fabre, Ludovic, Chouvet, Cédric, Soldevila, Stéphanie, Lamarque, Laurent, Donsimoni, Geoffrey, Roux, Thomas, Zwier, Jurriaan M, Trinquet, Eric, Rondard, Philippe, Pin, Jean-Philippe

“…Optimizing the signal-to-noise ratio in time-resolved FRET through generation of agonist-responsive cell-surface receptor biosensors, including GABA B…”
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Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics by Møller, Thor C., Hottin, Jerome, Clerté, Caroline, Zwier, Jurriaan M., Durroux, Thierry, Rondard, Philippe, Prézeau, Laurent, Royer, Catherine A., Pin, Jean-Philippe, Margeat, Emmanuel, Kniazeff, Julie

“…G protein coupled receptors (GPCRs) play essential roles in intercellular communication. Although reported two decades ago, the assembly of GPCRs into dimer…”
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