Search Results - "Zwicky, Pascale"

Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective by Zwicky, Pascale, Unger, Susanne, Becher, Burkhard

“…Chronic inflammatory diseases like psoriasis, Crohn's disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), and others are increasingly recognized…”
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IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival by Nur, Selim, Sparber, Florian, Lemberg, Christina, Guiducci, Eva, Schweizer, Tiziano A, Zwicky, Pascale, Becher, Burkhard, LeibundGut-Landmann, Salomé

“…The opportunistic fungal pathogen Candida albicans can cause invasive infections in susceptible hosts and the innate immune system, in particular myeloid…”
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Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation by Hartwig, Tom, Zwicky, Pascale, Schreiner, Bettina, Yawalkar, Nikhil, Cheng, Phil, Navarini, Alexander, Dummer, Reinhard, Flatz, Lukas, Conrad, Curdin, Schlapbach, Christoph, Becher, Burkhard

“…Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear…”
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Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature by Ingelfinger, Florian, Krishnarajah, Sinduya, Kramer, Michael, Utz, Sebastian G., Galli, Edoardo, Lutz, Mirjam, Zwicky, Pascale, Akarca, Ayse U., Jurado, Nicole Puertas, Ulutekin, Can, Bamert, David, Widmer, Corinne C., Piccoli, Luca, Sallusto, Federica, Núñez, Nicolás G., Marafioti, Teresa, Schneiter, Didier, Opitz, Isabelle, Lanzavecchia, Antonio, Jung, Hans H., De Feo, Donatella, Mundt, Sarah, Schreiner, Bettina, Becher, Burkhard

“…Myasthenia gravis (MG) is an autoimmune disease characterized by impaired neuromuscular signaling due to autoantibodies targeting the acetylcholine receptor…”
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Correction to: Single‑cell profiling of myasthenia gravis identifies a pathogenic T cell signature by Ingelfinger, Florian, Krishnarajah, Sinduya, Kramer, Michael, Utz, Sebastian G., Galli, Edoardo, Lutz, Mirjam, Zwicky, Pascale, Akarca, Ayse U., Jurado, Nicole Puertas, Ulutekin, Can, Bamert, David, Widmer, Corinne C., Piccoli, Luca, Sallusto, Federica, Núñez, Nicolás G., Marafioti, Teresa, Schneiter, Didier, Opitz, Isabelle, Lanzavecchia, Antonio, Jung, Hans H., De Feo, Donatella, Mundt, Sarah, Schreiner, Bettina, Becher, Burkhard

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Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids by Phan, Truong San, Schink, Leonhard, Mann, Jasmin, Merk, Verena M, Zwicky, Pascale, Mundt, Sarah, Simon, Dagmar, Kulms, Dagmar, Abraham, Susanne, Legler, Daniel F, Noti, Mario, Brunner, Thomas

“…Glucocorticoids (GC), synthesized by the 11β-hydroxylase (Cyp11b1), control excessive inflammation through immunosuppressive actions. The skin was proposed to…”
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Epidermal barrier impairment predisposes for excessive growth of the allergy‐associated yeast Malassezia on murine skin by Ruchti, Fiorella, Zwicky, Pascale, Becher, Burkhard, Dubrac, Sandrine, LeibundGut‐Landmann, Salomé

“…Background The skin barrier is vital for protection against environmental threats including insults caused by skin‐resident microbes. Dysregulation of this…”
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Twin study reveals non-heritable immune perturbations in multiple sclerosis by Ingelfinger, Florian, Gerdes, Lisa Ann, Kavaka, Vladyslav, Krishnarajah, Sinduya, Friebel, Ekaterina, Galli, Edoardo, Zwicky, Pascale, Furrer, Reinhard, Peukert, Christian, Dutertre, Charles-Antoine, Eglseer, Klara Magdalena, Ginhoux, Florent, Flierl-Hecht, Andrea, Kümpfel, Tania, De Feo, Donatella, Schreiner, Bettina, Mundt, Sarah, Kerschensteiner, Martin, Hohlfeld, Reinhard, Beltrán, Eduardo, Becher, Burkhard

“…Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and…”
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Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma by Kirschenbaum, Daniel, Xie, Ken, Ingelfinger, Florian, Katzenelenbogen, Yonatan, Abadie, Kathleen, Look, Thomas, Sheban, Fadi, Phan, Truong San, Li, Baoguo, Zwicky, Pascale, Yofe, Ido, David, Eyal, Mazuz, Kfir, Hou, Jinchao, Chen, Yun, Shaim, Hila, Shanley, Mayra, Becker, Soeren, Qian, Jiawen, Colonna, Marco, Ginhoux, Florent, Rezvani, Katayoun, Theis, Fabian J, Yosef, Nir, Weiss, Tobias, Weiner, Assaf, Amit, Ido

“…Deciphering the cell-state transitions underlying immune adaptation across time is fundamental for advancing biology. Empirical in vivo genomic technologies…”
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Correction to: Singleâcell profiling of myasthenia gravis identifies a pathogenic T cell signature by Ingelfinger, Florian, Krishnarajah, Sinduya, Kramer, Michael, Utz, Sebastian G, Galli, Edoardo, Lutz, Mirjam, Zwicky, Pascale

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Azathioprine therapy induces selective NK cell depletion and IFN-γ deficiency predisposing to herpesvirus reactivation by Ingelfinger, Florian, Sparano, Colin, Bamert, David, Reyes-Leiva, David, Sethi, Aakriti, Rindlisbacher, Lukas, Zwicky, Pascale, Kreutmair, Stefanie, Widmer, Corinne C., Mundt, Sarah, Cortés-Vicente, Elena, Tugues, Sonia, Becher, Burkhard, Schreiner, Bettina

“…Azathioprine is a widely prescribed drug for patients with chronic inflammatory diseases such as myasthenia gravis or organ transplant recipients. Azathioprine…”
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Lactation-associated macrophages exist in murine mammary tissue and human milk by Cansever, Dilay, Petrova, Ekaterina, Krishnarajah, Sinduya, Mussak, Caroline, Welsh, Christina A., Mildenberger, Wiebke, Mulder, Kevin, Kreiner, Victor, Roussel, Elsa, Stifter, Sebastian A., Andreadou, Myrto, Zwicky, Pascale, Jurado, Nicole Puertas, Rehrauer, Hubert, Tan, Ge, Liu, Zhaoyuan, Blériot, Camille, Ronchi, Francesca, Macpherson, Andrew J., Ginhoux, Florent, Natalucci, Giancarlo, Becher, Burkhard, Greter, Melanie

“…Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland remodeling…”
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IL-23 stabilizes an effector Treg cell program in the tumor microenvironment by Wertheimer, Tobias, Zwicky, Pascale, Rindlisbacher, Lukas, Sparano, Colin, Vermeer, Marijne, de Melo, Bruno Marcel Silva, Haftmann, Claudia, Rückert, Tamina, Sethi, Aakriti, Schärli, Stefanie, Huber, Anna, Ingelfinger, Florian, Xu, Caroline, Kim, Daehong, Häne, Philipp, Fonseca da Silva, André, Muschaweckh, Andreas, Nunez, Nicolas, Krishnarajah, Sinduya, Köhler, Natalie, Zeiser, Robert, Oukka, Mohamed, Korn, Thomas, Tugues, Sonia, Becher, Burkhard

“…Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and…”
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S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity by Silva de Melo, Bruno Marcel, Veras, Flávio Protásio, Zwicky, Pascale, Lima, Diógenes, Ingelfinger, Florian, Martins, Timna Varela, da Silva Prado, Douglas, Schärli, Stefanie, Publio, Gabriel, Hiroki, Carlos Hiroji, Melo, Paulo Henrique, Saraiva, André, Norbiato, Thainá, Lima, Leonardo, Ryffel, Bernhard, Vogl, Thomas, Roth, Johannes, Waisman, Ari, Nakaya, Helder I., da Silva Souza, Cacilda, Cunha, Fernando Q., Cunha, Thiago M., Becher, Burkhard, Alves-Filho, José C.

“…Psoriasis is a chronic inflammatory skin disorder driven by the IL-23/type 3 immune response. However, molecular mechanisms sustaining the chronicity of…”
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VLA-4 mediated adhesion of melanoma cells on the blood–brain barrier is the critical cue for melanoma cell intercalation and barrier disruption by García-Martín, Ana B, Zwicky, Pascale, Gruber, Thomas, Matti, Christoph, Moalli, Federica, Stein, Jens V, Francisco, David, Enzmann, Gaby, Levesque, Mitchell P, Hewer, Ekkehard, Lyck, Ruth

“…Melanoma is the most aggressive skin cancer in humans. One severe complication is the formation of brain metastasis, which requires extravasation of melanoma…”
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Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation by Saltarin, Federico, Wegmüller, Adrian, Bejarano, Leire, Ildiz, Ece Su, Zwicky, Pascale, Vianin, Andréj, Spadin, Florentin, Soukup, Klara, Wischnewski, Vladimir, Engelhardt, Britta, Deutsch, Urban, J Marques, Ines, Frenz, Martin, Joyce, Johanna A, Lyck, Ruth

“…Melanoma frequently metastasises to the brain, and a detailed understanding of the molecular and cellular mechanisms underlying melanoma cell extravasation…”
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Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice by Krishnarajah, Sinduya, Ingelfinger, Florian, Friebel, Ekaterina, Cansever, Dilay, Amorim, Ana, Andreadou, Myrto, Bamert, David, Litscher, Gioana, Lutz, Mirjam, Mayoux, Maud, Mundt, Sarah, Ridder, Frederike, Sparano, Colin, Stifter, Sebastian Anton, Ulutekin, Can, Unger, Susanne, Vermeer, Marijne, Zwicky, Pascale, Greter, Melanie, Tugues, Sonia, De Feo, Donatella, Becher, Burkhard

“…Aging exerts profound and paradoxical effects on the immune system, at once impairing proliferation, cytotoxicity and phagocytosis, and inducing chronic…”
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IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation by Zwicky, Pascale, Ingelfinger, Florian, Silva de Melo, Bruno Marcel, Ruchti, Fiorella, Schärli, Stefanie, Puertas, Nicole, Lutz, Mirjam, Phan, Truong San, Kündig, Thomas M, Levesque, Mitchell P, Maul, Julia-Tatjana, Schlapbach, Christoph, LeibundGut-Landmann, Salomé, Mundt, Sarah, Becher, Burkhard

“…Psoriasis is a chronic inflammatory skin disorder underpinned by dysregulated cytokine signaling. Drugs neutralizing the common p40 subunit of interleukin-12…”
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IL-23 stabilizes an effector T reg cell program in the tumor microenvironment by Wertheimer, Tobias, Zwicky, Pascale, Rindlisbacher, Lukas, Sparano, Colin, Vermeer, Marijne, de Melo, Bruno Marcel Silva, Haftmann, Claudia, Rückert, Tamina, Sethi, Aakriti, Schärli, Stefanie, Huber, Anna, Ingelfinger, Florian, Xu, Caroline, Kim, Daehong, Häne, Philipp, Fonseca da Silva, André, Muschaweckh, Andreas, Nunez, Nicolas, Krishnarajah, Sinduya, Köhler, Natalie, Zeiser, Robert, Oukka, Mohamed, Korn, Thomas, Tugues, Sonia, Becher, Burkhard

“…Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and…”
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Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T reg development by Haftmann, Claudia, Zwicky, Pascale, Ingelfinger, Florian, Mair, Florian, Floess, Stefan, Riedel, René, Durek, Pawel, Spalinger, Marianne R, Friebel, Ekaterina, Leung, Brian P, Lutz, Mirjam, Puertas, Nicole, Amorim, Ana, Schärli, Stefanie, Becher, Benedict, Kisielow, Jan, Waisman, Ari, Mashreghi, Mir-Farzin, Huehn, Jochen, Becher, Burkhard

“…Medullary thymic epithelial cells (mTECs) are key antigen-presenting cells mediating T cell tolerance to prevent harmful autoimmunity. mTECs both negatively…”
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