Search Results - "Zwick, Michael"

A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals by Walker, Laura M, Simek, Melissa D, Priddy, Frances, Gach, Johannes S, Wagner, Denise, Zwick, Michael B, Phogat, Sanjay K, Poignard, Pascal, Burton, Dennis R

“…A protective vaccine against HIV-1 will likely require the elicitation of a broadly neutralizing antibody (bNAb) response. Although the development of an…”
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High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells by Ingale, Jidnyasa, Stano, Armando, Guenaga, Javier, Sharma, Shailendra Kumar, Nemazee, David, Zwick, Michael B., Wyatt, Richard T.

“…A major step toward an HIV-1 vaccine is an immunogen capable of inducing neutralizing antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and…”
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Organizing core facilities as force multipliers: strategies for research universities by Zwick, Michael E

“…Force multipliers are attributes of an organization that enable the successful completion of multiple essential missions. Core facilities play a critical role…”
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Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice by Mangala Prasad, Vidya, Leaman, Daniel P., Lovendahl, Klaus N., Croft, Jacob T., Benhaim, Mark A., Hodge, Edgar A., Zwick, Michael B., Lee, Kelly K.

“…HIV-1 Env mediates viral entry into host cells and is the sole target for neutralizing antibodies. However, Env structure and organization in its native virion…”
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Organizing core facilities as force multipliers: strategies for research universities by Zwick, Michael E

“…Force multipliers are attributes of an organization that enable the successful completion of multiple essential missions. Core facilities play a critical role…”
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Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses by Bale, Shridhar, Goebrecht, Geraldine, Stano, Armando, Wilson, Richard, Ota, Takayuki, Tran, Karen, Ingale, Jidnyasa, Zwick, Michael B, Wyatt, Richard T

“…We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2…”
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Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization by Kim, Arthur S, Leaman, Daniel P, Zwick, Michael B

“…Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with…”
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Membrane Env Liposomes Facilitate Immunization with Multivalent Full-Length HIV Spikes by Leaman, Daniel P, Stano, Armando, Chen, Yajing, Zhang, Lei, Zwick, Michael B

“…A major goal of HIV vaccine design is to elicit broadly neutralizing antibodies (bNAbs). Such bNAbs target HIV's trimeric, membrane-embedded envelope…”
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Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease by Shaw, Kelly A, Bertha, Madeline, Hofmekler, Tatyana, Chopra, Pankaj, Vatanen, Tommi, Srivatsa, Abhiram, Prince, Jarod, Kumar, Archana, Sauer, Cary, Zwick, Michael E, Satten, Glen A, Kostic, Aleksandar D, Mulle, Jennifer G, Xavier, Ramnik J, Kugathasan, Subra

“…Gut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to…”
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Increased functional stability and homogeneity of viral envelope spikes through directed evolution by Leaman, Daniel P, Zwick, Michael B

“…The functional HIV-1 envelope glycoprotein (Env) trimer, the target of anti-HIV-1 neutralizing antibodies (Abs), is innately labile and coexists with…”
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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes by Li, Wenwei, Qin, Zhuan, Nand, Elizabeth, Grunst, Michael W., Grover, Jonathan R., Bess, Julian W., Lifson, Jeffrey D., Zwick, Michael B., Tagare, Hemant D., Uchil, Pradeep D., Mothes, Walther

“…Human immunodeficiency virus 1 (HIV-1) infection is initiated by binding of the viral envelope glycoprotein (Env) to the cell-surface receptor CD4 1 – 4 …”
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Microarray-based genomic selection for high-throughput resequencing by Zwick, Michael E, Okou, David T, Steinberg, Karyn Meltz, Middle, Christina, Cutler, David J, Albert, Thomas J

“…We developed a general method, microarray-based genomic selection (MGS), capable of selecting and enriching targeted sequences from complex eukaryotic genomes…”
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Structural definition of a conserved neutralization epitope on HIV-1 gp120 by Van Ryk, Donald, Wyatt, Richard, Dey, Barna, Zhang, Mei-Yun, Nabel, Gary J, Xu, Ling, Xiang, Shi-Hua, Dimitrov, Dimiter S, Sodroski, Joseph, Arthos, James, Yang, Xinzhen, Zhou, Tongqing, Kwong, Peter D, Hessell, Ann J, Burton, Dennis R, Zwick, Michael B

“…The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial…”
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Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers by Falkowska, Emilia, Le, Khoa M., Ramos, Alejandra, Doores, Katie J., Lee, Jeong Hyun, Blattner, Claudia, Ramirez, Alejandro, Derking, Ronald, van Gils, Marit J., Liang, Chi-Hui, Mcbride, Ryan, von Bredow, Benjamin, Shivatare, Sachin S., Wu, Chung-Yi, Chan-Hui, Po-Ying, Liu, Yan, Feizi, Ten, Zwick, Michael B., Koff, Wayne C., Seaman, Michael S., Swiderek, Kristine, Moore, John P., Evans, David, Paulson, James C., Wong, Chi-Huey, Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Poignard, Pascal, Burton, Dennis R.

“…Broadly neutralizing HIV antibodies are much sought after (a) to guide vaccine design, both as templates and as indicators of the authenticity of vaccine…”
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Correction: Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC) by Saba, Nabil F, Dinasarapu, Ashok R, Magliocca, Kelly R, Dwivedi, Bhakti, Seby, Sandra, Qin, Zhaohui S, Patel, Mihir, Griffith, Christopher C, Wang, Xu, El-Deiry, Mark, Steuer, Conor Ernst, Kowalski, Jeanne, Shin, Dong Moon, Zwick, Michael E, Chen, Zhuo Georgia

“…[This corrects the article DOI: 10.1371/journal.pone.0238497.]…”
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Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10 by Doyle-Cooper, Colleen, Hudson, Krystalyn E, Cooper, Anthony B, Ota, Takayuki, Skog, Patrick, Dawson, Phillip E, Zwick, Michael B, Schief, William R, Burton, Dennis R, Nemazee, David

“…A major goal of HIV research is to develop vaccines reproducibly eliciting broadly neutralizing Abs (bNAbs); however, this has proved to be challenging. One…”
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Structure and Complexity of a Bacterial Transcriptome by PASSALACQUA, Karla D, VARADARAJAN, Anjana, ONDOV, Brian D, OKOU, David T, ZWICK, Michael E, BERGMAN, Nicholas H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An MPER antibody neutralizes HIV-1 using germline features shared among donors by Zhang, Lei, Irimia, Adriana, He, Lingling, Landais, Elise, Rantalainen, Kimmo, Leaman, Daniel P., Vollbrecht, Thomas, Stano, Armando, Sands, Daniel I., Kim, Arthur S., Poignard, Pascal, Burton, Dennis R., Murrell, Ben, Ward, Andrew B., Zhu, Jiang, Wilson, Ian A., Zwick, Michael B.

“…The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER…”
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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies by Rantalainen, Kimmo, Berndsen, Zachary T., Antanasijevic, Aleksandar, Schiffner, Torben, Zhang, Xi, Lee, Wen-Hsin, Torres, Jonathan L., Zhang, Lei, Irimia, Adriana, Copps, Jeffrey, Zhou, Kenneth H., Kwon, Young D., Law, William H., Schramm, Chaim A., Verardi, Raffaello, Krebs, Shelly J., Kwong, Peter D., Doria-Rose, Nicole A., Wilson, Ian A., Zwick, Michael B., Yates, John R., Schief, William R., Ward, Andrew B.

“…Structural and functional studies of HIV envelope glycoprotein (Env) as a transmembrane protein have long been complicated by challenges associated with…”
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Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale by Kotlar, Alex V, Trevino, Cristina E, Zwick, Michael E, Cutler, David J, Wingo, Thomas S

“…Accurately selecting relevant alleles in large sequencing experiments remains technically challenging. Bystro ( https://bystro.io/ ) is the first online,…”
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