Search Results - "Zwerina, J"

Eosinophilic granulomatosis with polyangiitis (Churg–Strauss): state of the art by Vaglio, A., Buzio, C., Zwerina, J.

“…Eosinophilic granulomatosis with polyangiitis (Churg–Strauss, EGPA) is a systemic small‐vessel vasculitis associated with asthma and eosinophilia. Histology of…”
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The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis by Schett, G, Zwerina, J, Firestein, G

“…Chronic inflammatory processes are based on a sustained and tightly regulated communication network among different cells types. This network comprises…”
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Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study by Brozek, W., Reichardt, B., Zwerina, J., Dimai, H. P., Klaushofer, K., Zwettler, E.

“…Summary We analyzed the association of bisphosphonate therapy with mortality and hip refracture incidence among osteoporosis-related hip fracture patients in…”
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Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints by Uderhardt, S, Diarra, D, Katzenbeisser, J, David, J-P, Zwerina, J, Richards, W, Kronke, G, Schett, G

“…To study whether Dickkopf (DKK)-1, an inhibitor of wingless (Wnt) signalling, is involved in the fusion of sacroiliac joints. Mice transgenic for tumour…”
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Novel familial mutation of LRP5 causing high bone mass: Genetic analysis, clinical presentation, and characterization of bone matrix mineralization by Roetzer, K.M., Uyanik, G., Brehm, A., Zwerina, J., Zandieh, S., Czech, T., Roschger, P., Misof, B.M., Klaushofer, K.

“…The Wnt signalling pathway is a critical regulator of bone mass and quality. Several heterozygous mutations in the LRP5 gene, a Wnt co-receptor, causing high…”
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CTLA-4 directly inhibits osteoclast formation by Axmann, R, Herman, S, Zaiss, M, Franz, S, Polzer, K, Zwerina, J, Herrmann, M, Smolen, J, Schett, G

“…CTLA-4 is a regulator of co-stimulation and inhibits the activation of T cells through interfering with the interaction of CD80/86 on antigen-presenting cells…”
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Interleukin-1 is essential for systemic inflammatory bone loss by Polzer, K, Joosten, L, Gasser, J, Distler, J H, Ruiz, G, Baum, W, Redlich, K, Bobacz, K, Smolen, J S, van den Berg, W, Schett, G, Zwerina, J

“…Chronic inflammation is a major risk factor for systemic bone loss leading to osteoporotic fracture and substantial morbidity and mortality. Inflammatory…”
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Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations by Fratzl-Zelman, Nadja, Wesseling-Perry, Katherine, Mäkitie, Riikka E., Blouin, Stéphane, Hartmann, Markus A., Zwerina, Jochen, Välimäki, Ville-Valtteri, Laine, Christine M., Välimäki, Matti J., Pereira, Renata C., Mäkitie, Outi

“…Patients with osteoporosis-associated WNT1 or PLS3 mutations have unique bone histomorphometric features and osteocyte-specific hormone expression patterns. To…”
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Use of proton pump inhibitors and mortality after hip fracture in a nationwide study by Brozek, W., Reichardt, B., Zwerina, J., Dimai, H. P., Klaushofer, K., Zwettler, E.

“…Summary We analyzed the association of proton pump inhibitors (PPIs) with mortality after osteoporosis-related hip fracture in Austria. PPIs were associated…”
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WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production by Rauner, Martina, Stein, Nicola, Winzer, Maria, Goettsch, Claudia, Zwerina, Jochen, Schett, Georg, Distler, Jörg HW, Albers, Joachim, Schulze, Jochen, Schinke, Thorsten, Bornhäuser, Martin, Platzbecker, Uwe, Hofbauer, Lorenz C

“…WNT5A has recently been implicated in inflammatory processes, but its role as a bone marrow stromal cell (BMSC)–derived mediator of joint inflammation in…”
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Hemochromatosis by Oppl, B, Zwerina, J

“…Hereditary hemochromatosis is a frequent autosomal recessive iron storage disease in northern and western Europe. The classical clinical triad of liver…”
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Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis by Stickel, Felix, Buch, Stephan, Zoller, Heinz, Hultcrantz, Rolf, Gallati, Sabina, Österreicher, Christoph, Finkenstedt, Armin, Stadlmayr, Andreas, Aigner, Elmar, Sahinbegovic, Enijad, Sarrazin, Christoph, Schafmayer, Clemens, Braun, Felix, Erhart, Wiebke, Nothnagel, Michael, Lerch, Markus M, Mayerle, Julia, Völzke, Henry, Schaller, André, Kratzer, Wolfgang, Boehm, Bernhard O, Sipos, Bence, D'Amato, Mauro, Torkvist, Leif, Stal, Per, Arlt, Alexander, Franke, Andre, Becker, Thomas, Krawczak, Michael, Zwerina, Jochen, Berg, Thomas, Hinrichsen, Holger, Krones, Elisabeth, Dejaco, Christian, Strasser, Michael, Datz, Christian, Hampe, Jochen

“…Genome-wide association studies (GWAS) have revealed genetic determinants of iron metabolism, but correlation of these with clinical phenotypes is pending…”
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Eotaxin-3 is involved in Churg–Strauss syndrome – a serum marker closely correlating with disease activity by Polzer, K., Karonitsch, T., Neumann, T., Eger, G., Haberler, C., Soleiman, A., Hellmich, B., Csernok, E., Distler, J., Manger, B., Redlich, K., Schett, G., Zwerina, J.

“…Objective. Churg–Strauss Syndrome (CSS) is characterized by excessive eosinophil accumulation in peripheral blood and affected tissues with development of…”
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Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints by Polzer, K, Baeten, D, Soleiman, A, Distler, J, Gerlag, D M, Tak, P P, Schett, G, Zwerina, J

“…To investigate the presence and regulation of lymphatic vessels in inflamed joints of mice with experimental arthritis as well as patients with rheumatoid…”
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Variants in TM6SF2 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis by Buch, S, Way, M.J, Stickel, F, Ryan, E, Zoller, H, Griffiths, W.J.H, McQuillin, A, Zwerina, J, Ryan, J.D, Gallati, S, Berg, T, Datz, C, Gotthardt, D, Stewart, S, Hampe, J, Morgan, M.Y

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MALT lymphoma in patients with autoimmune diseases: a comparative analysis of characteristics and clinical course by WOHRER, S, TROCH, M, RADERER, M, STREUBEL, B, ZWERINA, J, SKRABS, C, FORMANEK, M, HAUFF, W, HOFFMANN, M, MÜLLAUER, L, CHOTT, A

“…MALT lymphoma, especially of extragastric origin, is thought to be associated with an underlying autoimmune disease (AD) in a significant proportion of…”
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Gender‐ and site‐specific differences of colorectal neoplasia relate to vitamin D by Aigner, E., Stadlmayr, A., Huber‐Schönauer, U., Zwerina, J., Husar‐Memmer, E., Niederseer, D., Trauner, M., Heuberger, A., Hohla, F., Schett, G., Patsch, W., Datz, C.

“…Summary Background The effect of vitamin D on colorectal adenomas may vary with regard to gender, localisation and histological type of the lesion. Aim To…”
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WNT16 antagonizes excessive canonical WNT activation and protects cartilage in osteoarthritis by Thomas, B.L, Nalesso, G, Yu, j, Addimanda, O, Sherwood, J, Dale, L, Schett, G, Zwerina, J, Eltawil, N, Pitzalis, C, Dell'Accio, F

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MAPK-activated protein kinase-2 (MK2) regulates osteoclastogenesis and bone turnover by Braun, T, Lepper, J, Luzeo, P, Rumpler, M, Schett, G, Zwerina, J

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Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo by van der Veen, Betty S, Chen, Min, Müller, Ralf, van Timmeren, Mirjan M, Petersen, Arjen H, Lee, Patrice A, Satchell, Simon C, Mathieson, Peter W, Saleem, Moin A, Stegeman, Coen A, Zwerina, Jochen, Molema, Grietje, Heeringa, Peter

“…To determine whether inhibition of p38 mitogen-activated protein kinase (p38MAPK) reduces the pathogenicity of anti-neutrophil cytoplasmic autoantibodies…”
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