Search Results - "Zweckstetter, M."

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution by Ukmar-Godec, T, Fang, P, Ibáñez de Opakua, A, Henneberg, F, Godec, A, Pan, K-T, Cima-Omori, M-S, Chari, A, Mandelkow, E, Urlaub, H, Zweckstetter, M

“…Intrinsically disordered proteins (IDPs) can be degraded in a ubiquitin-independent process by the 20 proteasome. Decline in 20 activity characterizes…”
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The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology by Luo, L, Hannemann, M, Koenig, S, Hegermann, J, Ailion, M, Cho, M-K, Sasidharan, N, Zweckstetter, M, Rensing, S A, Eimer, S

“…In yeast the Golgi-associated retrograde protein (GARP) complex is required for tethering of endosome-derived transport vesicles to the late Golgi. It consists…”
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Characterization of molecular alignment in aqueous suspensions of Pf1 bacteriophage by Zweckstetter, M, Bax, A

“…The phase diagram of Pf1 solutions has been studied indirectly by observation of 2H quadrupole splittings of the solvent signal and measurement of dipolar…”
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Single-Step Determination of Protein Substructures Using Dipolar Couplings:  Aid to Structural Genomics by Zweckstetter, Markus, Bax, Ad

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NMR in the SPINE Structural Proteomics project by AB, E., Atkinson, A. R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., Diercks, T., Dötsch, V., Engelke, F., Folkers, G. E., Griesinger, C., Gronwald, W., Günther, U., Habeck, M., De Jong, R. N., Kalbitzer, H. R., Kieffer, B., Leeflang, B. R., Loss, S., Luchinat, C., Marquardsen, T., Moskau, D., Neidig, K.-P., Nilges, M., Piccioli, M., Pierattelli, R., Rieping, W., Schippmann, T., Schwalbe, H., Travé, G., Trenner, J., Wöhnert, J., Zweckstetter, M., Kaptein, R.

“…This paper describes the developments, role and contributions of the NMR spectroscopy groups in the Structural Proteomics In Europe (SPINE) consortium…”
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P3.001 SUMOylation regulates a-synuclein toxicity by Bähr, M, Krumova, P, Meulmeester, E, Garrido, M, Tirard, M, Hisao, H.-S, Karpinar, P, Bossis, G, Wouters, F, Ruonala, M, Zweckstetter, M, Urlaub, H, Brose, N, Kügler, S, Melchior, F, Weishaupt, J

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Sumoylation inhibits alpha-synuclein aggregation and toxicity by Krumova, Petranka, Meulmeester, Erik, Garrido, Manuel, Tirard, Marilyn, Hsiao, He-Hsuan, Bossis, Guillaume, Urlaub, Henning, Zweckstetter, Markus, Kügler, Sebastian, Melchior, Frauke, Bähr, Mathias, Weishaupt, Jochen H

“…Posttranslational modification of proteins by attachment of small ubiquitin-related modifier (SUMO) contributes to numerous cellular phenomena. Sumoylation…”
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Prediction of Sterically Induced Alignment in a Dilute Liquid Crystalline Phase:  Aid to Protein Structure Determination by NMR by Zweckstetter, Markus, Bax, Ad

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Defining Long-Range Order and Local Disorder in Native α-Synuclein Using Residual Dipolar Couplings by Bernadó, Pau, Bertoncini, Carlos W, Griesinger, Christian, Zweckstetter, Markus, Blackledge, Martin

“…Intrinsically unstructured proteins play key biochemical roles in a vast range of normal and pathological processes. To study these systems, it is necessary to…”
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Release of Long-Range Tertiary Interactions Potentiates Aggregation of Natively Unstructured α-Synuclein by Bertoncini, Carlos W., Jung, Young-Sang, Fernandez, Claudio O., Hoyer, Wolfgang, Griesinger, Christian, Jovin, Thomas M., Zweckstetter, Markus, Petsko, Gregory A.

“…In idiopathic Parkinson's disease, intracytoplasmic neuronal inclusions (Lewy bodies) containing aggregates of the protein α-synuclein (αS) are deposited in…”
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Sites of Tau Important for Aggregation Populate β-Structure and Bind to Microtubules and Polyanions by Mukrasch, Marco D., Biernat, Jacek, von Bergen, Martin, Griesinger, Christian, Mandelkow, Eckhard, Zweckstetter, Markus

“…The aggregation of the microtubule-associated tau protein and formation of “neurofibrillary tangles” is one of the hallmarks of Alzheimer disease. The…”
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Mars -- robust automatic backbone assignment of proteins by Jung, Young-Sang, Zweckstetter, Markus

“…MARS a program for robust automatic backbone assignment of (13)C/(15)N labeled proteins is presented. MARS does not require tight thresholds for establishing…”
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Structural Integrity of the A147T Polymorph of Mammalian TSPO by Jaremko, Mariusz, Jaremko, Łukasz, Giller, Karin, Becker, Stefan, Zweckstetter, Markus

“…Ligands of the transmembrane protein TSPO are used for imaging of brain inflammation, but a common polymorphism in TSPO complicates their application to…”
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Extending the applicability of P3D for structure determination of small molecules by Ibáñez de Opakua, Alain, Zweckstetter, Markus

“…The application of anisotropic nuclear magnetic resonance (NMR) parameters for the correct structural assignment of small molecules requires the use of…”
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Structural Characterization of Copper(II) Binding to α-Synuclein: Insights into the Bioinorganic Chemistry of Parkinson's Disease by Rasia, Rodolfo M., Bertoncini, Carlos W., Marsh, Derek, Hoyer, Wolfgang, Cherny, Dmitry, Zweckstetter, Markus, Griesinger, Christian, Jovin, Thomas M., Fernández, Claudio O., Gray, Harry B.

“…The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II)…”
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Prediction of Charge-Induced Molecular Alignment of Biomolecules Dissolved in Dilute Liquid-Crystalline Phases by Zweckstetter, Markus, Hummer, Gerhard, Bax, Ad

“…Alignment of macromolecules in nearly neutral aqueous lyotropic liquid-crystalline media such as bicelles, commonly used in macromolecular NMR studies, can be…”
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Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation by Bertoncini, Carlos W., Fernandez, Claudio O., Griesinger, Christian, Jovin, Thomas M., Zweckstetter, Markus

“…A30P and A53T mutations of the presynaptic proteinα-synuclein are associated with familial forms of Parkinson disease. NMR spectroscopy demonstrates that…”
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Evaluation of uncertainty in alignment tensors obtained from dipolar couplings by Zweckstetter, Markus, Bax, Ad

“…Residual dipolar couplings and their corresponding alignment tensors are useful for structural analysis of macromolecules. The error in an alignment tensor,…”
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NMR of α-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation by Fernández, Claudio O, Hoyer, Wolfgang, Zweckstetter, Markus, Jares-Erijman, Elizabeth A, Subramaniam, Vinod, Griesinger, Christian, Jovin, Thomas M

“…The aggregation of α‐synuclein is characteristic of Parkinson's disease (PD) and other neurodegenerative synucleinopathies. The 140‐aa protein is natively…”
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A Ligand-Induced Switch in the Periplasmic Domain of Sensor Histidine Kinase CitA by Sevvana, Madhumati, Vijayan, Vinesh, Zweckstetter, Markus, Reinelt, Stefan, Madden, Dean R., Herbst-Irmer, Regine, Sheldrick, George M., Bott, Michael, Griesinger, Christian, Becker, Stefan

“…Sensor histidine kinases of two-component signal-transduction systems are essential for bacteria to adapt to variable environmental conditions. However,…”
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