Search Results - "Zwartkruis, Fried J"

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion by Khalil, Antoine A., Smits, Daan, Haughton, Peter D., Koorman, Thijs, Jansen, Karin A., Verhagen, Mathijs P., van der Net, Mirjam, van Zwieten, Kitty, Enserink, Lotte, Jansen, Lisa, El-Gammal, Abdelrahman G., Visser, Daan, Pasolli, Milena, Tak, Max, Westland, Denise, van Diest, Paul J., Moelans, Cathy B., Roukens, M. Guy, Tavares, Sandra, Fortier, Anne-Marie, Park, Morag, Fodde, Riccardo, Gloerich, Martijn, Zwartkruis, Fried. J. T., Derksen, Patrick WB, de Rooij, Johan

“…Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a…”
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Evolution of the TOR Pathway by van Dam, Teunis J. P., Zwartkruis, Fried J. T., Bos, Johannes L., Snel, Berend

“…The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR pathway are implicated in cancer and metabolic diseases in humans…”
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Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress by Zimmer, Till S., Korotkov, Anatoly, Zwakenberg, Susan, Jansen, Floor E., Zwartkruis, Fried J. T., Rensing, Nicholas R., Wong, Michael, Mühlebner, Angelika, Vliet, Erwin A., Aronica, Eleonora, Mills, James D.

“…Tuberous sclerosis complex (TSC) is a congenital disorder characterized by cortical malformations and concomitant epilepsy caused by loss‐of‐function mutations…”
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Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy by Rumping, Lynne, Büttner, Benjamin, Maier, Oliver, Rehmann, Holger, Lequin, Maarten, Schlump, Jan-Ulrich, Schmitt, Bernhard, Schiebergen-Bronkhorst, Birgit, Prinsen, Hubertus C M T, Losa, Michele, Fingerhut, Ralph, Lemke, Johannes R, Zwartkruis, Fried J T, Houwen, Roderick H J, Jans, Judith J M, Verhoeven-Duif, Nanda M, van Hasselt, Peter M, Jamra, Rami

“…The identification and understanding of the monogenic causes of neurodevelopmental disorders are of high importance for personalized treatment and genetic…”
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The long-term effect of mTOR inhibition on lipid and glucose metabolism in tuberous sclerosis complex: data from the Dutch TSC registry by Mulder, Femke V M, Peeters, Evelien F H I, Westerink, Jan, Zwartkruis, Fried J T, de Ranitz-Greven, Wendela L

“…MTOR inhibition is an effective treatment for many manifestations of tuberous sclerosis complex. Because mTOR inhibition is a disease modifying therapy,…”
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CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation by De Rubeis, Silvia, Pasciuto, Emanuela, Li, Ka Wan, Fernández, Esperanza, Di Marino, Daniele, Buzzi, Andrea, Ostroff, Linnaea E., Klann, Eric, Zwartkruis, Fried J.T., Komiyama, Noboru H., Grant, Seth G.N., Poujol, Christel, Choquet, Daniel, Achsel, Tilmann, Posthuma, Danielle, Smit, August B., Bagni, Claudia

“…The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia…”
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Metabolic Alterations in NADSYN1-Deficient Cells by Meijer, Nils W F, Gerrits, Johan, Zwakenberg, Susan, Zwartkruis, Fried J T, Verhoeven-Duif, Nanda M, Jans, Judith J M

“…NAD synthetase 1 (encoded by the gene NADSYN1) is a cytosolic enzyme that catalyzes the final step in the biosynthesis of nicotinamide adenine dinucleotide…”
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Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes by Meijer, Nils W F, Zwakenberg, Susan, Gerrits, Johan, Westland, Denise, Ardisasmita, Arif I, Fuchs, Sabine A, Verhoeven-Duif, Nanda M, Jans, Judith J M, Zwartkruis, Fried J T

“…Direct infusion-high-resolution mass spectrometry (DI-HRMS) allows for rapid profiling of complex mixtures of metabolites in blood, cerebrospinal fluid, tissue…”
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Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation by van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij‐Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago‐Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, Klumperman, Judith

“…Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent…”
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A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization by Bruurs, Lucas J. M., Zwakenberg, Susan, van der Net, Mirjam C., Zwartkruis, Fried J., Bos, Johannes L.

“…Signaling by the small GTPase Cdc42 governs a diverse set of cellular processes that contribute to tissue morphogenesis. Since these processes often require…”
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Amino Acids Mediate mTOR/Raptor Signaling through Activation of Class 3 Phosphatidylinositol 3OH-Kinase by Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Dann, Stephen G., Kim, So Young, Gulati, Pawan, Byfield, Maya P., Backer, Jonathan M., Natt, Francois, Bos, Johannes L., Fried J. T. Zwartkruis, Thomas, George, Schlessinger, Joseph

“…During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway…”
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Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins by Gloerich, Martijn, Ponsioen, Bas, Vliem, Marjolein J., Zhang, Zhongchun, Zhao, Jun, Kooistra, Matthijs R., Price, Leo S., Ritsma, Laila, Zwartkruis, Fried J., Rehmann, Holger, Jalink, Kees, Bos, Johannes L.

“…OA  Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP by Bos, Johannes L, de Rooij, Johan, Zwartkruis, Fried J. T, Verheijen, Mark H. G, Cool, Robbert H, Nijman, Sebastian M. B, Wittinghofer, Alfred

“…Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells by Ras. Rap1 is activated by…”
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ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization by Bruurs, Lucas J M, Donker, Lisa, Zwakenberg, Susan, Zwartkruis, Fried J, Begthel, Harry, Knisely, A S, Posthuma, George, van de Graaf, Stan F J, Paulusma, Coen C, Bos, Johannes L

“…During yeast cell polarization localization of the small GTPase, cell division control protein 42 homologue (Cdc42) is clustered to ensure the formation of a…”
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Rap1A-Deficient T and B Cells Show Impaired Integrin-Mediated Cell Adhesion by Duchniewicz, Marlena, Zemojtel, Tomasz, Kolanczyk, Mateusz, Grossmann, Steffen, Scheele, Jürgen S., Zwartkruis, Fried J. T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization by Bruurs, Lucas J M, van der Net, Mirjam C, Zwakenberg, Susan, Zwartkruis, Fried J T, Bos, Johannes L

“…Apico-basal polarity establishment is a seminal process in tissue morphogenesis. To function properly it is often imperative that epithelial cells limit apical…”
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Rheb and mammalian target of rapamycin in mitochondrial homoeostasis by Groenewoud, Marlous J., Zwartkruis, Fried J. T.

“…Mitochondrial dysfunction has been associated with various diseases, such as cancer, myopathies, neurodegeneration and obesity. Mitochondrial homoeostasis is…”
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Ras and macropinocytosis： trick and treat by Zwartkruis, Fried J T, Burgering, Boudewijn M T

“…Oncogene-driven adaptation of metabolism during tumorigenesis includes steps that stimulate the up- take of nutrients, especially glucose and glutamine, to…”
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Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts by Groenewoud, Marlous J, Goorden, Susan M I, Kassies, Jorien, Pellis-van Berkel, Wendy, Lamb, Richard F, Elgersma, Ype, Zwartkruis, Fried J T

“…The Ras-like GTPase Rheb has been identified as a crucial activator of mTORC1. Activation most likely requires a direct interaction between Rheb and mTOR, but…”
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Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells by Geest, Christian R, Zwartkruis, Fried J, Vellenga, Edo, Coffer, Paul J, Buitenhuis, Miranda

“…1 Molecular Immunology Lab, Department of Immunology, UMC, Utrecht; 2 Department of Physiological Chemistry, Centre for Biomedical Genetics, UMC Utrecht,…”
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