Search Results - "Zwarthoff, EC"

Genomic and Transcriptomic Characterization of Metastatic Urothelial Carcinoma by Nakauma, A, Rijnders, M, van Riet, J, van der Heijden, MS, Voortman, J, Cuppen, E, Mehra, N, van Wilpe, S, Oosting, S, Zwarthoff, EC, de Wit, R, van der Veldt, AAM, van de Werken, HJG, Lolkema, MPJ, Boormans, JL

“…Standard treatment for patients with metastatic urothelial carcinoma (mUC) consists of platinum-based chemotherapy, and recently systemic immunotherapy has…”
Get full text

Molecular Grading of Urothelial Cell Carcinoma With Fibroblast Growth Factor Receptor 3 and MIB-1 is Superior to Pathologic Grade for the Prediction of Clinical Outcome by VAN RHIJN, Bas W. G, VIS, André N, VAN DER KWAST, Theo H, KIRKELS, Wim J, RADVANYI, Francois, OOMS, Engelbert C. M, CHOPIN, Dominique K, BOEVE, Egbert R, JÖBSIS, Adriaan C, ZWARTHOFF, Ellen C

“…Fibroblast growth factor receptor 3 (FGFR3) mutations were recently found at a high frequency in well-differentiated urothelial cell carcinoma (UCC). We…”
Get full text

A Simple and Fast Method for the Simultaneous Detection of Nine Fibroblast Growth Factor Receptor 3 Mutations in Bladder Cancer and Voided Urine by VAN OERS, Johanna M. M, LURKIN, Irene, VAN EXSEL, Antonius J. A, NIJSEN, Yvette, VAN RHIJN, Bas W. G, VAN DER AA, Madelon N. M, ZWARTHOFF, Ellen C

“…Purpose: Mutations in the fibroblast growth factor receptor 3 ( FGFR3 ) occur in 50% of primary bladder tumors. An FGFR3 mutation is associated with good…”
Get full text

FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma by VAN RHIJN, Bas W. G, VAN DER KWAST, Theo H, VIS, André N, KIRKELS, Wim J, BOEVE, Egbert R, JÖBSIS, Adriaan C, ZWARTHOFF, Ellen C

“…Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. We here describe the distribution of FGFR3 mutations…”
Get full text

The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate by VAN RHIJN, Bas W. G, LURKIN, Irene, RADVANYI, Francois, KIRKELS, Wim J, VAN DER KWAST, Theodorus H, ZWARTHOFF, Ellen C

“…We analyzed the possible prognostic value of the recently discovered fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer. A FGFR3 mutation…”
Get full text

Frequent FGFR3 mutations in urothelial papilloma by van Rhijn, Bas W. G., Montironi, Rodolfo, Zwarthoff, Ellen C., Jöbsis, Adriaan C., van der Kwast, Theo H.

“…Activating point mutations in the FGFR3 gene occur frequently in low‐grade and low‐stage bladder carcinomas, whereas they are rare in high‐grade carcinomas…”
Get full text

Absence of TERT promoter mutations in esophageal adenocarcinoma by Nistelrooij, A.M.J., Zwarthoff, E.C., Post, E., Lurkin, I., Marion, R., Kopershoek, E., Biermann, K., Wijnhoven, B.P.L., Dinjens, W.N.M.

Get full text

Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders by van Rhijn, Bas W G, van Tilborg, Angela A G, Lurkin, Irene, Bonaventure, Jacky, de Vries, Annie, Thiery, Jean-Paul, van der Kwast, Theodorus H, Zwarthoff, Ellen C, Radvanyi, Francois

“…Activating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene are responsible for several autosomal dominant craniosynostosis syndromes and…”
Get full text

A new system for substaging pT1 papillary bladder cancer: a prognostic evaluation by van der Aa, Madelon N.M., van Leenders, Geert J.L.H., Steyerberg, Ewout W., van Rhijn, Bas W., Jöbsis, Adriaan C., Zwarthoff, Ellen C., van der Kwast, Theodorus H.

“…Superficially invasive (pT1) papillary urothelial cell carcinomas (UCCs) may run a variable course. Several attempts have been made for the substaging of UCC…”
Get full text

Targeted Disruption of the Mn1 Oncogene Results in Severe Defects in Development of Membranous Bones of the Cranial Skeleton by Meester-Smoor, Magda A., Vermeij, Marcel, van Helmond, Marjolein J. L., Molijn, Anco C., van Wely, Karel H. M., Hekman, Arnold C. P., Vermey-Keers, Christl, Riegman, Peter H. J., Zwarthoff, Ellen C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription by VAN WELY, Karel H. M, MOLIJN, Anco C, BUIJS, Arjan, MEESTER-SMOOR, Magda A, AARNOUDSE, Albert Jan, HELLEMONS, Anita, DEN BESTEN, Pim, GROSVELD, Gerard C, ZWARTHOFF, Ellen C

“…The t(12;22) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the ETS family of transcription…”
Get full text

Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger by Wild, PJ, Giedl, J, Stoehr, R, Junker, K, Boehm, S, van Oers, JMM, Zwarthoff, EC, Blaszyk, H, Fine, SW, Humphrey, PA, Dehner, LP, Amin, MB, Epstein, JI, Hartmann, A

“…Urothelial neoplasms in patients 19 years of age or younger are rare, and the data regarding clinical outcome are conflicting. Molecular data are not…”
Get full text

Combined Microsatellite and FGFR3 Mutation Analysis Enables a Highly Sensitive Detection of Urothelial Cell Carcinoma in Voided Urine by VAN RHIJN, Bas W. G, LURKIN, Irene, CHOPIN, Dominique K, KIRKELS, Wim J, THIERY, Jean-Paul, VAN DER KWAST, Theo H, RADVANYI, Francois, ZWARTHOFF, Ellen C

“…Purpose: Fibroblast growth factor receptor 3 (FGFR3 ) mutations were reported recently at a high frequency in low-grade urothelial cell carcinoma (UCC). We…”
Get full text

Molecular evolution of multiple recurrent cancers of the bladder by VAN TILBORG, Angela A. G, DE VRIES, Annie, DE BONT, Maarten, GROENFELD, Lilian E, VAN DER KWAST, Theo H, ZWARTHOFF, Ellen C

“…We describe the reconstruction of bladder tumor development in individual patients spanning periods of up to 17 years. Genomic alterations detected in the…”
Get full text

Lack of genetic and epigenetic changes in meningiomas without NF2 loss by van Tilborg, Angela AG, Morolli, Bruno, Giphart-Gassler, Micheline, de Vries, Annie, van Geenen, Daniëlle AN, Lurkin, Irene, Kros, Johan M, Zwarthoff, Ellen C

“…Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumour suppressor gene. The causative gene for the remaining meningiomas is…”
Get full text

A noninvasive multi-analyte diagnostic assay: combining protein and DNA markers to stratify bladder cancer patients by Fernandez, Cecilia A, Millholland, John M, Zwarthoff, Ellen C, Feldman, Adam S, Karnes, R Jeffrey, Shuber, Anthony P

“…The authors recently reported the development of a noninvasive diagnostic assay using urinary matrix metalloproteinases (MMPs) as monitors of disease-free…”
Get full text

The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity by Buijs, Arjan, van Rompaey, Luc, Molijn, Anco C., Davis, J. Nathan, Vertegaal, Alfred C. O., Potter, Mark D., Adams, Constantin, van Baal, Sjozèf, Zwarthoff, Ellen C., Roussel, Martine F., Grosveld, Gerard C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Chromosomal instability in meningiomas by VAN TILBORG, Angela A. G, AL ALLAK, Bushra, VELTHUIZEN, Sandra C. J. M, DE VRIES, Annie, KROS, Johan M, AVEZAAT, Cees J. J, DE KLEIN, Annelies, BEMA BEVERLOO, H, ZWARTHOFF, Ellen C

“…Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumor suppressor gene on chromosome 22. No causative gene is known for the…”
Get full text

The chromosome 9q genes TGFBR1, TSC1, and ZNF189 are rarely mutated in bladder cancer by van Tilborg, Angela A. G., de Vries, Annie, Zwarthoff, Ellen C.

“…This study assessed a series of bladder tumours and bladder tumour cell lines for sequence variation in the Krüppel‐like zinc finger gene ZNF189, the tuberous…”
Get full text

PCN9 COST-EFFECTIVENESS OF SUPERFICIAL BLADDER CANCER SURVEILLANCE IN WHICH CYSTOSCOPY IS PARTLY REPLACED BY MICROSATELLITE ANALYSIS by De Bekker-Grob, EW, Van der Aa, MNM, Zwarthoff, EC, Meerding, WJ, Eijkemans, MJC, Van Rhijn, BWG, Van der Kwast, TH, Steyerberg, EW

Get full text