Search Results - "Zwaginga, Jaap J."

A functional spleen contributes to afucosylated IgG in humans by Wojcik, Iwona, Schmidt, David E., de Neef, Lisa A., Rab, Minke A. E., Meek, Bob, de Weerdt, Okke, Wuhrer, Manfred, van der Schoot, C. Ellen, Zwaginga, Jaap J., de Haas, Masja, Falck, David, Vidarsson, Gestur

“…As a lymphoid organ, the spleen hosts a wide range of immune cell populations, which not only remove blood-borne antigens, but also generate and regulate…”
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Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of β1 and β2 integrins by Martins, Paula A. da Costa, Gils, Janine M., Mol, Anita, Hordijk, Peter L., Zwaginga, Jaap J.

“…Human monocytes adhere to activated platelets, resulting in the formation of platelet‐monocyte complexes (PMC). Complex formation depends on the interaction…”
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The haemostatic effect of deep-frozen platelets versus room temperature-stored platelets in the treatment of surgical bleeding: MAFOD—study protocol for a randomized controlled non-inferiority trial by Rijnhout, Tim W. H, Noorman, Femke, van der Horst, Robert A, Tan, Edward C. T. H, Viersen, Victor V. A, van Waes, Oscar J. F, van de Watering, Leo M. G, van der Burg, B. L. S. Borger, Zwaginga, Jaap J, Verhofstad, Michael H. J, Hoencamp, Rigo

“…Abstract Background The Netherlands Armed Forces have been successfully using deep-frozen (− 80 °C) thrombocyte concentrate (DTC) for the treatment of…”
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Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans by Bisoendial, Radjesh J, Kastelein, John J.P, Levels, Johannes H.M, Zwaginga, Jaap J, van den Bogaard, Bas, Reitsma, Pieter H, Meijers, Joost C.M, Hartman, Daniel, Levi, Marcel, Stroes, Erik S.G

“…C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on…”
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Antibodies against Platelet Glycoproteins in Clinically Suspected VITT Patients by Meier, Romy T, Porcelijn, Leendert, Hofstede-van Egmond, Suzanne, Caram-Deelder, Camila, Coutinho, Jonathan M, Henskens, Yvonne M C, Kruip, Marieke J H A, Stroobants, An K, Zwaginga, Jaap J, van der Schoot, C Ellen, de Haas, Masja, Kapur, Rick

“…Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare but severe complication following COVID-19 vaccination, marked by thrombocytopenia and thrombosis…”
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MEIS1 regulates early erythroid and megakaryocytic cell fate by Zeddies, Sabrina, Jansen, Sjoert B G, di Summa, Franca, Geerts, Dirk, Zwaginga, Jaap J, van der Schoot, C Ellen, von Lindern, Marieke, Thijssen-Timmer, Daphne C

“…MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests…”
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Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: An intra-patient comparison by Rodrigo, Sander F., MD, van Ramshorst, Jan, MD, Beeres, Saskia L., MD, PhD, Al Younis, Imad, MD, Dibbets-Schneider, Petra, BSc, de Roos, Albert, MD, PhD, Fibbe, Willem E., MD, PhD, Zwaginga, Jaap J., MD, PhD, Schalij, Martin J., MD, PhD, Bax, Jeroen J., MD, PhD, Atsma, Douwe E., MD, PhD

“…Background We recently demonstrated in a randomized, double-blind, placebo-controlled trial that intramyocardial bone marrow cell (BMC) injection is associated…”
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Detection of platelet autoantibodies to identify immune thrombocytopenia: state of the art by Porcelijn, Leendert, Huiskes, Elly, Oldert, Gonda, Schipperus, Martin, Zwaginga, Jaap J., Haas, Masja

“…Summary Immune Thrombocytopenia (ITP) is diagnosed by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would…”
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Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes by Nikolic, Tatjana, Zwaginga, Jaap J, Uitbeijerse, Bas S, Woittiez, Nicky J, de Koning, Eelco J, Aanstoot, Henk-Jan, Roep, Bart O

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Risk Factors, Treatment, and Immune Dysregulation in Autoimmune Cytopenia after Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients by Kruizinga, Matthijs D., van Tol, Maarten J.D., Bekker, Vincent, Netelenbos, Tanja, Smiers, Frans J., Bresters, Dorine, Jansen-Hoogendijk, Anja M., van Ostaijen-ten Dam, Monique M., Kollen, Wouter J.W., Zwaginga, Jaap J., Lankester, Arjan C., Bredius, Robbert G.M.

“…•Autoimmune cytopenia after stem cell transplantation is a rare complication.•Nonmalignant disease, alemtuzumab use, and CMV reactivation are risk factors.•The…”
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Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial by van der Meer, Pieter F., Ypma, Paula F., van Geloven, Nan, van Hilten, Joost A., van Wordragen-Vlaswinkel, Rinie J., Eissen, Okke, Zwaginga, Jaap J., Trus, Michael, Beckers, Erik A.M., te Boekhorst, Peter, Tinmouth, Alan, Lin, Yulia, Hsia, Cyrus, Lee, David, Norris, Philip J., Goodrich, Raymond P., Brand, Anneke, Hervig, Tor, Heddle, Nancy M., van der Bom, Johanna G., Kerkhoffs, Jean-Louis H.

“…Pathogen inactivation of platelet concentrates reduces the risk for blood-borne infections. However, its effect on platelet function and hemostatic efficacy of…”
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Intramyocardial Bone Marrow Cell Injection for Chronic Myocardial Ischemia: A Randomized Controlled Trial by van Ramshorst, Jan, Bax, Jeroen J, Beeres, Saskia L. M. A, Dibbets-Schneider, Petra, Roes, Stijntje D, Stokkel, Marcel P. M, de Roos, Albert, Fibbe, Willem E, Zwaginga, Jaap J, Boersma, Eric, Schalij, Martin J, Atsma, Douwe E

“…CONTEXT Previous studies have suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular (LV) function in patients with…”
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What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings by ten Ham, Renske M.T., Hövels, Anke M., Hoekman, Jarno, Frederix, Geert W.J., Leufkens, Hubert G.M., Klungel, Olaf H., Jedema, Inge, Veld, Sabrina A.J., Nikolic, Tatjana, Van Pel, Melissa, Zwaginga, Jaap J., Lin, Fong, de Goede, Anna L., Schreibelt, Gerty, Budde, Sandy, de Vries, I. Jolanda M., Wilkie, Gwen M., Dolstra, Harry, Ovelgönne, Hans, Meij, Pauline, Mountford, Joanne C., Turner, Marc L., Hoefnagel, Marcel H.N.

“…Recent technical and clinical advances with cell-based therapies (CBTs) hold great promise in the treatment of patients with rare diseases and those with high…”
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Generation and infusion of multi-antigen-specific T cells to prevent complications early after T-cell depleted allogeneic stem cell transplantation—a phase I/II study by Roex, Marthe C. J., van Balen, Peter, Germeroth, Lothar, Hageman, Lois, van Egmond, Esther, Veld, Sabrina A. J., Hoogstraten, Conny, van Liempt, Ellis, Zwaginga, Jaap J., de Wreede, Liesbeth C., Meij, Pauline, Vossen, Ann C. T. M., Danhof, Sophia, Einsele, Hermann, Schaafsma, M. Ron, Veelken, Hendrik, Halkes, Constantijn J. M., Jedema, Inge, Falkenburg, J. H. Frederik

“…Prophylactic infusion of selected donor T cells can be an effective method to restore specific immunity after T-cell-depleted allogeneic stem cell…”
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Laboratory approach for vaccine‐induced thrombotic thrombocytopenia diagnosis in the Netherlands by Meier, Romy T., Porcelijn, Leendert, Hofstede‐van Egmond, Suzanne, Henskens, Yvonne M. C., Coutinho, Jonathan M., Kruip, Marieke J. H. A., Stroobants, An K., Zwaginga, Jaap J., van der Bom, Johanna G., van der Schoot, C. Ellen, de Haas, Masja, Kapur, Rick

“…Background and Objectives Vaccine‐induced thrombotic thrombocytopenia (VITT) is a rare adverse effect characterized by thrombocytopenia and thrombosis…”
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The association between haemorrhage and markers of endothelial insufficiency and inflammation in patients with hypoproliferative thrombocytopenia: a cohort study by Ypma, Paula F., Geloven, Nan, Kerkhoffs, Jean Louis H., Boekhorst, Peter, Zwaginga, Jaap J., Beckers, Erik A. M., Brand, Anneke, Meer, Pieter F., Eikenboom, Jeroen C. J.

“…Summary In daily haematological practice, predicting bleeding in thrombocytopenic patients is difficult, and clinicians adhere to transfusion triggers to guide…”
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Treatment and outcomes of fetal/neonatal alloimmune thrombocytopenia: a nationwide cohort study in newly detected cases by Winkelhorst, Dian, Oostweegel, Michelle, Porcelijn, Leendert, Middelburg, Rutger A., Zwaginga, Jaap J., Oepkes, Dick, Bom, Johanna G., Haas, Masja, Lopriore, Enrico

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Preparation of Cytokine-activated NK Cells for Use in Adoptive Cell Therapy in Cancer Patients: Protocol Optimization and Therapeutic Potential by van Ostaijen-ten Dam, Monique M, Prins, Henk-Jan, Boerman, Gerharda H, Vervat, Carly, Pende, Daniela, Putter, Hein, Lankester, Arjan, van Tol, Maarten J D, Zwaginga, Jaap J, Schilham, Marco W

“…Cell-based immunotherapy using donor-derived natural killer (NK) cells after allogeneic hematopoietic stem cell transplantation may be an attractive treatment…”
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Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial by Bonten, T N, Saris, A, van Oostrom, M J, Snoep, J D, Rosendaal, F R, Zwaginga, J, Eikenboom, J, van der Meer, P F, van der Bom, J G

“…The risk of acute cardiovascular events is highest during morning hours, and platelet activity peaks during morning hours. The effect of timing of aspirin…”
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Effect of alemtuzumab-based T-cell depletion on graft compositional change in vitro and immune reconstitution early after allogeneic stem cell transplantation by Roex, Marthe C.J., Wijnands, Charissa, Veld, Sabrina A.J., van Egmond, Esther, Bogers, Lisette, Zwaginga, Jaap J., Netelenbos, Tanja, von dem Borne, Peter A., Veelken, Hendrik, Halkes, Constantijn J.M., Falkenburg, J.H. Frederik, Jedema, Inge

“…To reduce the risk of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloSCT), T-cell depletion (TCD) of grafts can be performed…”
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