Search Results - "Zwacka, R."

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells by Leach, D. A., Mohr, A., Giotis, E. S., Cil, E., Isac, A. M., Yates, L. L., Barclay, W. S., Zwacka, R. M., Bevan, C. L., Brooke, G. N.

“…SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of…”
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Reactive oxygen species in oncogenic transformation by Behrend, L, Henderson, G, Zwacka, R M

“…Ever since ROS (reactive oxygen species) were shown to meet the criteria of true signalling molecules, such as regulated production and a specific biological…”
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Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects by Yu, R, Deedigan, L, Albarenque, S M, Mohr, A, Zwacka, R M

“…Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs…”
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MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac DIABLO release by Mohr, A, Büneker, C, Gough, R P, Zwacka, R M

“…The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side,…”
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Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells by Stark, L A, Din, F V, Zwacka, R M, Dunlop, M G

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NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition by LA FERLA-BRÜHL, K, WESTHOFF, M. A, KARL, S, KASPERCZYK, H, ZWACKA, R. M, DEBATIN, K. M, FULDA, S

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Therapeutic approaches for ischemia/reperfusion injury in the liver by CHENGUANG FAN, ZWACKA, R. M, ENGELHARDT, J. F

“…Organ injury caused by transient ischemia followed by reperfusion is associated with a number of clinically and environmentally induced conditions…”
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Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity by Gonzalez-Zulueta, Mirella, Ensz, Lisa M, Mukhina, Galina, Lebovitz, Russell M, Zwacka, Ralf M, Engelhardt, John F, Oberley, Larry W, Dawson, Valina L, Dawson, Ted M

“…Neuronal nitric oxide synthase (nNOS) neurons kill adjacent neurons through the action of NMDA-glutamate receptor activation, although they remain relatively…”
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Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy by EPPERLY, M, BRAY, J, KRAEGER, S, ZWACKA, R, ENGELHARDT, J, TRAVIS, E, GREENBERGER, J

“…Organ and tissue damage caused by ionizing irradiation is directly related to volume irradiated, total dose and dose rate. The acute effects are in part…”
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Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells by Brown, Michael R, Miller, Francis J, Li, Wei-Gen, Ellingson, Andy N, Mozena, Jonathan D, Chatterjee, Papri, Engelhardt, John F, Zwacka, Ralf M, Oberley, Larry W, Fang, Xiang, Spector, Arthur A, Weintraub, Neal L

“…The role of reactive oxygen species, such as superoxide anions (O2) and hydrogen peroxide (H2O2), in modulating vascular smooth muscle cell proliferation and…”
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AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression by MOHR, A, HENDERSON, G, DUDUS, L, HERR, I, KUERSCHNER, T, DEBATING, K.-M, WEIHER, H, FISHER, K. J, ZWACKA, R. M

“…Gene transfer vectors based on the adeno-associated virus (AAV) are used for various experimental and clinical therapeutic approaches. In the present study, we…”
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Betulinic acid as new activator of NF-κB : molecular mechanisms and implications for cancer therapy by KASPERCZYK, Hubert, LA FERLA-BRÜHL, Katia, WESTHOFF, Mike Andrew, BEHREND, Lars, ZWACKA, Ralf Michael, DEBATIN, Klaus-Michael, FULDA, Simone

“…Recent evidence demonstrates that the anticancer activity of betulinic acid (BetA) can be markedly increased by combination protocols, for example with…”
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A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release by Mohr, A, Zwacka, R M, Debatin, K-M, Stahnke, K

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CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver by Zwacka, R M, Zhang, Y, Halldorson, J, Schlossberg, H, Dudus, L, Engelhardt, J F

“…The success of orthotopic liver transplantation is dependent on multiple factors including MHC tissue compatibility and ischemic/reperfusion injury…”
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Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation by Zwacka, Ralf M, Zhou, Weihong, Zhang, Yulong, Darby, Christine J, Dudus, Lorita, Halldorson, Jeff, Oberley, Larry, Engelhardt, John F

“…Liver transplantation is the only therapeutic strategy for many inherited and acquired diseases. The formation of reactive oxygen species following…”
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Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells by Fang, Xiang, Weintraub, Neal L, Rios, C. David, Chappell, David A, Zwacka, Ralf M, Engelhardt, John F, Oberley, Larry W, Yan, Tao, Heistad, Donald D, Spector, Arthur A

“…Oxidation of LDL in the subendothelial space has been proposed to play a key role in atherosclerosis. Endothelial cells produce superoxide anions (O (2) sup…”
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Ischemia/reperfusion injury in the liver of BALB/c mice activates AP‐1 and nuclear factor κB independently of IκB degradation by Zwacka, Ralf M., Zhang, Yulong, Zhou, Weihong, Halldorson, Jeff, Engelhardt, John F.

“…For many inherited and acquired hepatic diseases, liver transplantation is the only possible therapeutic strategy. Ischemia/reperfusion (I/R) damage to donor…”
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The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells by Fritz, E, Friedl, A A, Zwacka, R M, Eckardt-Schupp, F, Meyn, M S

“…Homozygous mutations in the human ATM gene lead to a pleiotropic clinical phenotype of ataxia-telangiectasia (A-T) patients and correlating cellular…”
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Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis by MOHR, Andrea, ZWACKA, Ralf Michael, JARMY, Gergely, BÜNEKER, Chirlei, SCHREZENMEIER, Hubert, DÖHNER, Konstanze, BELTINGER, Christian, WIESNETH, Markus, DEBATIN, Klaus-Michael, STAHNKE, Karsten

“…Regulation of sensitivity or resistance for apoptosis by death receptor ligand systems is a key control mechanism in the hematopoietic system. Dysfunctional or…”
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Gene therapy for colon cancer by Zwacka, R M, Dunlop, M G

“…The enormous number of newly diagnosed cases of colorectal cancer that occur each year and the lack of agents that are highly effective for all patients…”
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