Search Results - "Zvezdova, Ekaterina"
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Themis2 lowers the threshold for B cell activation during positive selection
Published in Nature immunology (01-02-2017)“…Cornall and colleagues show that Themis2 interacts with the phospholipase PLC-γ2 and lowers the threshold for B cell activation by low but not high avidity…”
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Single high-dose treatment with glucosaminyl-muramyl dipeptide is ineffective in treating ankylosing spondylitis
Published in Rheumatology international (01-08-2011)“…Earlier studies have shown that high doses of TNF-alpha increase apoptosis in human autoimmune T-cell clones. Based on these studies, a treatment approach was…”
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THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1
Published in Nature immunology (01-04-2017)“…Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1…”
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Dendritic cell development—History, advances, and open questions
Published in Seminars in immunology (01-12-2015)“…Highlights • History of Dendritic cell discovery as a member of mononuclear phagocyte system. • Recent discoveries of dendritic cell development and its…”
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Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1
Published in Nature immunology (01-06-2017)“…Nat. Immunol.; doi:10.1038/ni.3692; corrected online 7 March 2017 In the version of this article initially published online, in the second sentence of the…”
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THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1
Published in Nature immunology (27-02-2017)“…THEMIS, a T cell specific protein that is highly expressed in CD4 + CD8 + thymocytes, has a crucial role in positive selection and T cell development. THEMIS…”
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Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability
Published in Science signaling (17-05-2016)“…The T cell signaling protein Themis1 is essential for the positive and negative selection of thymocytes in the thymus. Although the developmental defect that…”
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TCR ITAM multiplicity is required for the generation of follicular helper T-cells
Published in Nature communications (11-05-2015)“…The T-cell antigen receptor (TCR) complex contains 10 copies of a di-tyrosine Immunoreceptor-Tyrosine-based-Activation-Motif (ITAM) that initiates TCR…”
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Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
Published in The Journal of immunology (1950) (01-08-2012)“…Themis1, a recently identified T cell protein, has a critical function in the generation of mature CD4(+)CD8(-) and CD4(-)CD8(+) (CD4 and CD8 single-positive…”
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NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation
Published in Science immunology (10-06-2022)“…Although BTB-zinc finger (BTB-ZF) transcription factors control the differentiation of multiple hematopoietic and immune lineages, how they function is poorly…”
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In vivo functional mapping of the conserved protein domains within murine Themis1
Published in Immunology and cell biology (01-09-2014)“…Thymocyte development requires the coordinated input of signals that originate from numerous cell surface molecules. Although the majority of thymocyte…”
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