Search Results - "Zuurbier, Kielen R"
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Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms
Published in The Journal of neuroscience (29-01-2020)“…Recovery after stroke is a multicellular process encompassing neurons, resident immune cells, and brain-invading cells. Stroke alters the gut microbiome, which…”
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Impaired meningeal lymphatic vessel development worsens stroke outcome
Published in Journal of cerebral blood flow and metabolism (01-02-2020)“…The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to…”
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Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
Published in Nature communications (05-03-2021)“…Mechanical stimuli initiate adaptive signal transduction pathways, yet exceeding the cellular capacity to withstand physical stress results in death. The…”
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Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
Published in eLife (02-09-2021)“…Concussion is associated with a myriad of deleterious immediate and long-term consequences. Yet the molecular mechanisms and genetic targets promoting the…”
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Cytosolic dopamine determines hypersensitivity to blunt force trauma
Published in iScience (21-06-2024)“…The selective vulnerability of dopaminergic neurons to trauma-induced neurodegeneration is conserved across species, from nematodes to humans. However, the…”
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Intracellular lipid surveillance by small G protein geranylgeranylation
Published in Nature (London) (26-05-2022)“…Imbalances in lipid homeostasis can have deleterious effects on health 1 , 2 . Yet how cells sense metabolic demand due to lipid depletion and respond by…”
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Reduced bone morphogenic protein signaling along the gut–neuron axis by heat shock factor promotes longevity
Published in Aging cell (01-09-2022)“…Aging is a complex and highly regulated process of interwoven signaling mechanisms. As an ancient transcriptional regulator of thermal adaptation and protein…”
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Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice
Published in Endocrinology (Philadelphia) (01-11-2018)“…Estrogens provide neuroprotection in animal models of stroke, but uterotrophic effects and cancer risk limit translation. Classic estrogen receptors (ERs)…”
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