Search Results - "Zusi, C."

Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes by Mantovani, A., Turino, T., Lando, M.G., Gjini, K., Byrne, C.D., Zusi, C., Ravaioli, F., Colecchia, A., Maffeis, C., Salvagno, G., Lippi, G., Bonora, E., Targher, G.

“…Despite the high prevalence and serious clinical implications of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM),…”
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Gender disparity in editorial boards of scientific journals in endocrinology by Mantovani, A., Rinaldi, E., Zusi, C.

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Association between PNPLA3rs738409 polymorphism decreased kidney function in postmenopausal type 2 diabetic women with or without non-alcoholic fatty liver disease by Mantovani, A., Zusi, C., Sani, E., Colecchia, A., Lippi, G., Zaza, G.L., Valenti, L., Byrne, C.D., Maffeis, C., Bonora, E., Targher, G.

“…Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD])…”
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Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11) by Zusi, C., Rinaldi, E., Bonetti, S., Boselli, M. L., Trabetti, E., Malerba, G., Bonora, E., Bonadonna, R. C., Trombetta, M.

“…Background Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase…”
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Association between MBOAT7 rs641738 polymorphism and non-alcoholic fatty liver in overweight or obese children by Zusi, C., Morandi, A., Maguolo, A., Corradi, M., Costantini, S., Mosca, A., Crudele, A., Mantovani, A., Alisi, A., Miraglia del Giudice, E., Targher, G., Maffeis, C.

“…The association between non-alcoholic fatty liver (NAFL) and the variant rs641738 within the membrane bound O-acyltransferase domain-containing 7 (MBOAT7) gene…”
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Role of monogenic diabetes genes on beta cell function in Italian patients with newly diagnosed type 2 diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 13 by Bonetti, S., Zusi, C., Rinaldi, E., Boselli, ML, Csermely, A., Malerba, G., Trabetti, E., Bonora, E., Bonadonna, R.C., Trombetta, M.

“…We tested the hypothesis that common genetic variability of beta-cell genes responsible for monogenic diabetes may affect beta cell function in type 2 diabetes…”
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Enantiomer Discrimination Illustrated by High-Resolution Crystal Structures of the Human Nuclear Receptor hRARγ by Klaholz, Bruno P., Mitschler, Andre, Belema, Makonen, Zusi, C., Moras, Dino

“…The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent…”
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Two distinct actions of retinoid-receptor ligands by Chen, Jia-Yang, Clifford, John, Zusi, Chris, Starrett, John, Tortolani, David, Ostrowski, Jacek, Reczek, Peter R, Chambon, Pierre, Gronemeyer, Hinrich

“…Signalling by all-trans retinoic acid is mediated through RXR-RAR retinoid receptor heterodimers, in which RXR has been considered to act as a…”
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Cell-Type and Promoter-Context Dependent Retinoic Acid Receptor (RAR) Redundancies for RARβ 2 and Hoxa-1 Activation in F9 and P19 Cells can be Artefactually Generated by Gene Knockouts by Taneja, Reshma, Roy, Bidyut, Plassat, Jean-Luc, Zusi, Chris F., Ostrowski, Jacek, Reczek, Peter R., Chambon, Pierre

“…By using RAR type (α , β , or γ )-specific synthetic retinoids and a pan-retinoic X receptor (RXR)-specific ligand, we have investigated the contribution of…”
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An inhibitor of I Kappa B kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice by MacMaster, J F, Dambach, D M, Lee, D B, Berry, K K, Qiu, Y, Zusi, F C, Burke, J R

“…Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic relapsing inflammation. The transcription of many of…”
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Conformational adaptation of agonists to the human nuclear receptor RARγ by Klaholz, B.P, Renaud, J.-P, Mitschler, A, Zusi, C, Chambon, P, Gronemeyer, H, Moras, D

“…The nuclear retinoid receptors RARs and RXRs are transcriptional regulators whose activity is mediated by their ligand-binding domain. The crystal structures…”
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An inhibitor of I?B kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice by MacMaster, J. F., Dambach, D. M., Qiu, Y., Zusi, F. C., Burke, J. R., Lee, D. B., Berry, K. K.

“…Objective:Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic relapsing inflammation. The transcription of…”
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Progress in the discovery of BACE inhibitors by Thompson, Lorin A, Bronson, Joanne J, Zusi, F Christopher

“…Dementia caused by Alzheimer's disease is a large medical burden on society in the developed world. Current treatments are largely symptomatic, and there is an…”
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Selective retinoids and rexinoids in cancer therapy and chemoprevention by Zusi, F.Christopher, Lorenzi, Matthew V, Vivat-Hannah, Valerie

“…Natural and synthetic retinoids are effective inhibitors of tumor cell growth in vitro and in vivo. However, the toxicity of natural derivatives of vitamin A…”
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The requirement for a retinoic acid lactone of 11-cis, 13-cis-stereochemistry for topical dermatologic activity by LEWIN, A. H, GOEHRING, R. R, ZUSI, F. C, GENDIMENICO, G. J, XINA NAIR, WHITTING, G, BOUQUIN, P, TETRAULT, G, CARROLL, F. I

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Evaluation of retinoids as therapeutic agents in dermatology by LEWIN, A. H, BOS, M. E, ZUSI, F. C, NAIR, X, WHITING, G, BOUQIN, P, TETRAULT, G, CARROLL, F. I

“…Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to…”
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A highly selective inhibitor of IkB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection by Townsend, R M, Postelnek, J, Susulic, V, McIntyre, K W, Shuster, D J, Qiu, Y, Zusi, F C, Burke, J R

“…Background. We previously demonstrated in vitro and in vivo that an IkB kinase (IKK) inhibitor blocks cytokine production and suppresses immune responses…”
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The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families by Prandini, Paola, Pasquali, Alessandra, Malerba, Giovanni, Marostica, Andrea, Zusi, Chiara, Xumerle, Luciano, Muglia, Pierandrea, Da Ros, Lucio, Ratti, Emiliangelo, Trabetti, Elisabetta, Pignatti, Pier Franco

“…The objective of this study was to replicate an association study on a newly collected Italian autism spectrum disorder (ASD) cohort by studying the genetic…”
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Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with Taxol (paclitaxel) by VIVAT-HANNAH, Valerie, DAN YOU, RIZZO, Cheryl, DARIS, Jean-Paul, LAPOINTE, Philippe, ZUSI, F. Christopher, MARINIER, Anne, LORENZI, Matthew V, GOTTARDIS, Marco M

“…The focus of this study was to develop retinoic acid receptor (RAR) RAR alpha/beta selective agonists with anticancer efficacy and reduced toxicity associated…”
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Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma by Klaholz, B P, Mitschler, A, Belema, M, Zusi, C, Moras, D

“…The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent…”
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