Search Results - "Zuosheng Liu"

Au(I)-Catalyzed Annulation of Enantioenriched Allenes in the Enantioselective Total Synthesis of (−)-Rhazinilam by Liu, Zuosheng, Wasmuth, Andrew S, Nelson, Scott G

“…Highly stereoselective Au(I)-catalyzed pyrrole additions to enantioenriched allenes afford a unique entry to optically active heterocycles. Asymmetric…”
Get full text

Exploratory Studies Aimed at a Synthesis of Vinigrol. 2. Attempts to Exploit Ring-Closing Metathesis for Construction of the Central Cyclooctane Belt by Paquette, Leo A, Efremov, Ivan, Liu, Zuosheng

“…A program directed to the possible adaptation of ring closing metathesis to a total synthesis of vinigrol is described. With a convenient route to…”
Get full text

Exploratory Studies Aimed at a Synthesis of Vinigrol. 4. Probe of Possible Means for Direct Connection of the Side Arms and of Ring-Contraction Alternatives by Paquette, Leo A, Liu, Zuosheng, Efremov, Ivan

“…Attempts have been made to gain access to the vinigrol structural framework by way of three routes. These include reductive transannular cyclization,…”
Get full text

Three-color two-photon three-axis digital scanned light-sheet microscopy (3C2P3A-DSLM) by Weijian Zong, Zuosheng Liu, Fuzeng Niu, Shaowa Li, Jia Zhao, Aimin Wang, Liangyi Chen

“…We demonstrate a new two-photon light-sheet microscopy with three-color excitation, diffraction-limited thickness and tailorable illumination area, capable of…”
Get full text

High power 780 nm femtosecond fiber laser by Zuosheng Liu, Weijian Zong, Yizhou Liu, Lijun Zuo, Cai Wen, Tongxiao Jiang, Jian Zhang, Yuxuan Ma, Zhigang Zhang, Liangyi Chen, Aimin Wang

“…We demonstrate an 880 mW 780 nm femtosecond laser based on a high-order dispersion compensated Er-doped fiber laser and frequency doubling. It has been used on…”
Get full text

Synthetic Studies Aimed at (−)-Cochleamycin A. Evaluation of Late-Stage Macrocyclization Alternatives by Paquette, Leo A, Chang, Jiyoung, Liu, Zuosheng

“…An efficient route to the fully functionalized ABC ring systems of the unnatural enantiomer of cochleamycin A was developed. l-(−)-Malic and l-(−)-ascorbic…”
Get full text

Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors by Huang, Shenlin, Liu, Zuosheng, Tian, Shin-Shay, Sandberg, Mark, Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Wang, Zhiliang, Karanewsky, Donald, He, Yun

“…A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Many…”
Get full text

Competitive Stereochemical Control Operative during Conrotatory Electrocyclization of Helically Equilibrating Diquinanyl-Substituted 1,3,5,7-Octatetraenyl Bisenolates by Paquette, Leo A, Liu, Zuosheng, Ramsey, Charla, Gallucci, Judith C

“…Activation of the squarate ester cascade by adding the lithiated bicyclo[3.3.0]octene 20 and vinyllithium sequentially to 1 results in the isolation of the…”
Get full text

Synthesis of β-Amino-α-hydroxy Esters and β-Amino-α-azido Ester by Sharpless Asymmetric Aminohydroxylation, Byproducts Analysis by Liu, Zuosheng, Ma, Nianchun, Jia, Yanxing, Bois-Choussy, Michèle, Malabarba, Adriano, Zhu, Jieping

“…Synthesis of enantiomerically pure β-amino-α-hydroxy esters (1, 2) and β-amino-α-azido ester (3) using Sharpless AA as a key step is described. A hitherto…”
Get full text

Design and synthesis of macrocycles active against vancomycin-resistant enterococci (VRE): the interplay between d-Ala- d-Lac binding and hydrophobic effect by Ma, Nianchun, Jia, Yanxing, Liu, Zuosheng, Gonzalez-Zamora, Eduardo, Bois-Choussy, Michèle, Malabarba, Adriano, Brunati, Cristina, Zhu, Jieping

“…[Display omitted] A modified vancomycin binding pocket (D–O–E ring) incorporating a CHNHCOR function at the AA4 position is designed and synthesized. Potent…”
Get full text

Identification of synthetic compounds active against VRE: the role of the lipidated aminoglucose and the structure of glycopeptide binding pocket by Jia, Yanxing, Gonzalez-Zamora, Eduardo, Ma, Nianchun, Liu, Zuosheng, Bois-Choussy, Michèle, Malabarba, Adriano, Brunati, Cristina, Zhu, Jieping

“…Synthesis of modified vancomycin binding pocket (D–O–E ring) incorporating a ( R)- or ( S)-configured secondary alcohol function at the AA4 position is…”
Get full text

An efficient total synthesis of (±)-sinulariol-B by Yue, Xiangjun, Lan, Jiong, Li, Jing, Liu, Zuosheng, Lin, Yulin

“…The first total synthesis of (±)-Sinulariol-B, a marine cembrandiol, was achieved in ten steps and ∼10% overall yield from E-geraniol ( 8). The key steps were…”
Get full text

First Total Synthesis of (+)-Caparratriene by Li, Jing, Liu, Zuosheng, Lan, Jiong, Li, Yulin

“…Caparratriene (1), a new sesquiterpene hydrocarbon with significant growth inhibitory activity against CEM leukemia cells, was first synthesized starting from…”
Get full text

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models by Albaugh, Pam, Fan, Yi, Mi, Yuan, Sun, Fangxian, Adrian, Francisco, Li, Nanxin, Jia, Yong, Sarkisova, Yelena, Kreusch, Andreas, Hood, Tami, Lu, Min, Liu, Guoxun, Huang, Shenlin, Liu, Zuosheng, Loren, Jon, Tuntland, Tove, Karanewsky, Donald S, Seidel, H. Martin, Molteni, Valentina

“…Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating…”
Get full text

First total synthesis of three cembrene diterpenoids by Jing, LI, Jiong, LAN, Zuosheng, LIU, Ying, LI, Yulin, LI

“…The first total synthesis of three diterpenoids of the cembrane class, is described. And the absolute stereochemistry of these natural products is assigned by…”
Get full text

Design and Synthesis of Simple Macrocycles Active Against Vancomycin-Resistant Enterococci (VRE) by Jia, Yanxing, Ma, Nianchun, Liu, Zuosheng, Bois-Choussy, Michèle, Gonzalez-Zamora, Eduardo, Malabarba, Adriano, Brunati, Cristina, Zhu, Jieping

“…16‐membered meta,para‐cyclophanes mimicking the vancomycin binding pocket (D–O–E ring) were designed and synthesized. The structural key features of these…”
Get full text

Facile one-pot transformation of 2,3-epoxy alcohols into allylic alcohols: first total synthesis of (−)-4- O-(6′-hydroxy-7′(9′)-dehydro-6′,7′-dihydrogeranyl)coniferol by Liu, Zuosheng, Lan, Jiong, Li, Yulin

“…An efficient and practical synthesis of optically active allylic alcohols from 2,3-epoxy alcohols by the in situ formation of the epoxy iodides and their…”
Get full text

First enantioselective total synthesis of (−)-13-hydroxyneocembrene by Liu, Zuosheng, Zhang, Tao, Li, Yulin

“…The first enantioselective total synthesis of (−)-13-hydroxyneocembrene ( 1 ), a naturally occurring cembranoids isolated from soft coral Sarcophyton…”
Get full text

Enantioselective total synthesis of (+)-3,4-epoxycembrene-A by Liu, Zuosheng, Li, Weidong Z., Li, Yulin

“…A concise and efficient total synthesis of (+)-3,4-epoxycembrene-A 1, an epoxy cembrane diterpenoid from tropical marine soft coral, is described. The…”
Get full text

First total synthesis and absolute configuration of marine cembrane diterpenoid (+)-11,12-epoxysarcophytol A by Lan, Jiong, Liu, Zuosheng, Yuan, Hao, Peng, Lizeng, Li, Wei-Dong Z, Li, Ying, Li, Yulin, Chan, Albert S.C

“…A concise and efficient total synthesis of (+)-11,12-epoxysarcophytol A ( 1), an epoxy cembrane diterpenoid from marine soft coral Lobophytum, is described,…”
Get full text