Search Results - "Zuo, Zehua"
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ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth
Published in Proceedings of the National Academy of Sciences - PNAS (03-01-2023)“…The limited efficacy of the current antitumor microenvironment strategies is due in part to the poor understanding of the roles and relative contributions of…”
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Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen
Published in PLoS genetics (15-10-2020)“…Diphthamide is a unique post-translationally modified histidine residue (His715 in all mammals) found only in eukaryotic elongation factor-2 (eEF-2). The…”
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Life satisfaction and parental support among secondary school students in Urumqi: the mediation of physical activity
Published in PeerJ (San Francisco, CA) (10-11-2022)“…This study is aimed to analyze the relationship between parental support, physical activity and life satisfaction among secondary school students in Urumqi…”
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Pivotal Role of Reduced let-7g Expression in Breast Cancer Invasion and Metastasis
Published in Cancer research (Chicago, Ill.) (15-10-2011)“…Screening of the entire let-7 family of microRNAs (miRNA) by in situ hybridization identified let-7g as the only member, the diminished expression of which was…”
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Oncogenic activity of SLC45A2‐AMACR
Published in The FASEB journal (01-04-2020)“…Abstract only Significant number of human cancers contains gene fusion between solute carrier family 45, member 2 (SLC45A2) and α‐methylacyl‐CoA racemase…”
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Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system
Published in mBio (07-11-2024)“…Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin…”
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Abstract 2717: A potent and highly tumor-selective KRAS inactivator for tumor targeting
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Cancer driver mutations in the RAS-RAF-MEK-ERK pathway occur in 46% of all human cancers. This has inspired the successful development of many small…”
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Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors
Published in Cell host & microbe (09-09-2020)“…Bacteria and their toxins are associated with significant human morbidity and mortality. While a few bacterial toxins are well characterized, the mechanism of…”
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A potent tumor-selective ERK pathway inactivator with high therapeutic index
Published in PNAS nexus (01-07-2022)“…FDA-approved BRAF and MEK small molecule inhibitors have demonstrated some level of efficacy in patients with metastatic melanomas. However, these "targeted"…”
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Herpes Simplex Virus 2 infection up‐regulates TLRs expression and activates NF‐kB in human cervical epithelial cells
Published in The FASEB journal (01-03-2008)“…Abstract only Toll‐like receptors (TLRs) play a crucial role in the innate immune response against microbial infections, engaging differential signaling…”
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Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma
Published in Tumor biology (01-01-2006)“…Our previous study has suggested thatthe bladder cancer-associated protein gene (BLCAP) was among the differentially expressed genes in cervical cancer. We…”
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