Spatiotemporal analysis of imported and local dengue virus and cases in a metropolis in Southwestern China, 2013–2022

Spatiotemporal analysis of imported and local dengue virus and cases in a metropolis in Southwestern China, 2013–2022

•We analyse the characteristics of Chongqing's first local dengue outbreak.•Dengue virus’ evolutionary dynamics and phylogenetic relationship were explored.•Dengue fever's epidemic trend during the COVID-19 pandemic was analysed.•Dengue fever's epidemiological distribution during 2013...

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Bibliographic Details
Published in:Acta tropica Vol. 257; p. 107308
Main Authors: Tu, Taotian, Yang, Jing, Xiao, Hansen, Zuo, Youyi, Tao, Xiaoying, Ran, Yaling, Yuan, Yi, Ye, Sheng, He, Yaming, Wang, Zheng, Tang, Wenge, Liu, Qiyong, Ji, Hengqing, Li, Zhichao
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-09-2024
Subjects:
Aedes - virology
Animals
China
China - epidemiology
Chongqing
Cities - epidemiology
Communicable Diseases, Imported - epidemiology
Communicable Diseases, Imported - transmission
Communicable Diseases, Imported - virology
Dengue - epidemiology
Dengue - transmission
Dengue - virology
Dengue fever
Dengue Virus - classification
Dengue Virus - genetics
Disease Outbreaks
Epidemiology
Genetic evolution
Humans
Mosquito Vectors - virology
Phylogeny
Spatio-Temporal Analysis
Vector
China
Genetic evolution
Chongqing
Vector
Epidemiology
Dengue fever
China
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Summary:•We analyse the characteristics of Chongqing's first local dengue outbreak.•Dengue virus’ evolutionary dynamics and phylogenetic relationship were explored.•Dengue fever's epidemic trend during the COVID-19 pandemic was analysed.•Dengue fever's epidemiological distribution during 2013–2022 was explored. Dengue fever is a viral illness, mainly transmitted by Aedes aegypti and Aedes albopictus. With climate change and urbanisation, more urbanised areas are becoming suitable for the survival and reproduction of dengue vector, consequently are becoming suitable for dengue transmission in China. Chongqing, a metropolis in southwestern China, has recently been hit by imported and local dengue fever, experiencing its first local outbreak in 2019. However, the genetic evolution dynamics of dengue viruses and the spatiotemporal patterns of imported and local dengue cases have not yet been elucidated. Hence, this study implemented phylogenetic analyses using genomic data of dengue viruses in 2019 and 2023 and a spatiotemporal analysis of dengue cases collected from 2013 to 2022. We sequenced a total of 15 nucleotide sequences of E genes. The dengue viruses formed separate clusters and were genetically related to those from Guangdong Province, China, and countries in Southeast Asia, including Laos, Thailand, Myanmar and Cambodia. Chongqing experienced a dengue outbreak in 2019 when 168 imported and 1,243 local cases were reported, mainly in September and October. Few cases were reported in 2013–2018, and only six were imported from 2020 to 2022 due to the COVID-19 lockdowns. Our findings suggest that dengue prevention in Chongqing should focus on domestic and overseas population mobility, especially in the Yubei and Wanzhou districts, where airports and railway stations are located, and the period between August and October when dengue outbreaks occur in endemic regions. Moreover, continuous vector monitoring should be implemented, especially during August–October, which would be useful for controlling the Aedes mosquitoes. This study is significant for defining Chongqing's appropriate dengue prevention and control strategies.
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ISSN:0001-706X
1873-6254
1873-6254
DOI:10.1016/j.actatropica.2024.107308