Search Results - "Zuniga, Leandro"

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons by Plant, Leigh D, Zuniga, Leandro, Araki, Dan, Marks, Jeremy D, Goldstein, Steve A N

“…The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We…”
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Transverse permeability in Eucalyptus nitens wood specimens by Ananías, Rubén A., Leandro-Zúñiga, Laura, Pérez-Peña, Natalia, Salvo-Sepúlveda, Linette, Cloutier, Alain

“…Permeability functionalities are noticeable in the wood drying and impregnation processes because it has an effect on the bulk flow of a fluid through the wood…”
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Collapse of Eucalyptus nitens Wood After Drying Depending on the Radial Location Within the Stem by Ananías, Rubén A, Sepúlveda-Villarroel, Victor, Pérez-Peña, Natalia, Leandro-Zuñiga, Laura, Salvo-Sepúlveda, Linette, Salinas-Lira, Carlos, Cloutier, Alain, Elustondo, Diego M

“…Collapse is almost certain to occur in the industrial drying of Eucalyptus nitens and, as such this prevents the lumber manufacturing industry in Chile from…”
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Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways by Cabrera, Lissette, Saavedra, Andrea, Rojas, Susana, Cid, Marcela, Valenzuela, Cristina, Gallegos, David, Careaga, Pamela, Basualto, Emerita, Haensgen, Astrid, Peña, Eduardo, Rivas, Coralia, Vera, Juan Carlos, Gallardo, Victoria, Zúñiga, Leandro, Escudero, Carlos, Sobrevia, Luis, Wareing, Mark, González, Marcelo

“…Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin…”
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HCN Channels: New Therapeutic Targets for Pain Treatment by Ramírez, David, Zúñiga, Rafael, Concha, Guierdy, Zúñiga, Leandro

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are highly regulated proteins which respond to different cellular stimuli. The HCN currents…”
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TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines by Cikutović-Molina, Rocio, Herrada, Andres A, González, Wendy, Brown, Nelson, Zúñiga, Leandro

“…Incidence and mortality of gastric cancer is increasing worldwide, in part, because of the lack of new therapeutic targets to treat this disease. Different…”
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Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3 by Zúñiga, Rafael, Concha, Guierdy, Cayo, Angel, Cikutović-Molina, Rocio, Arevalo, Bárbara, González, Wendy, Catalán, Marcelo A., Zúñiga, Leandro

“…[Display omitted] •-Inhibitory role of WFA on TASK-3 channels activity.•-Inhibition of TASK-3 channels activity in cancer cells by WFA.•-WFA inhibits TASK-3 by…”
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TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines by Zúñiga, Rafael, Valenzuela, Claudio, Concha, Guierdy, Brown, Nelson, Zúñiga, Leandro

“…TASK-3 potassium channels are believed to promote proliferation and survival of cancer cells, in part, by augmenting their resistance to both hypoxia and serum…”
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K+-Driven Cl−/HCO3− Exchange Mediated by Slc4a8 and Slc4a10 by Peña-Münzenmayer, Gaspar, George, Alvin T., Llontop, Nuria, Mazola, Yuliet, Apablaza, Natalia, Spichiger, Carlos, Brauchi, Sebastián, Sarmiento, José, Zúñiga, Leandro, González, Wendy, Catalán, Marcelo A.

“…Slc4a genes encode various types of transporters, including Na+-HCO3− cotransporters, Cl−/HCO3− exchangers, or Na+-driven Cl−/HCO3− exchangers. Previous…”
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Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Arévalo, Bárbara, Bedoya, Mauricio, Kiper, Aytug K., Vergara, Fernando, Ramírez, David, Mazola, Yuliet, Bustos, Daniel, Zúñiga, Rafael, Cikutovic, Rocio, Cayo, Angel, Rinné, Susanne, Ramirez-Apan, M. Teresa, Sepúlveda, Francisco V., Cerda, Oscar, López-Collazo, Eduardo, Decher, Niels, Zúñiga, Leandro, Gutierrez, Margarita, González, Wendy

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series…”
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Expression and cellular localization of HCN channels in rat cerebellar granule neurons by Zúñiga, Rafael, González, Daniela, Valenzuela, Claudio, Brown, Nelson, Zúñiga, Leandro

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the superfamily of voltage-gated pore loop channels. In mammals, this family…”
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Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening by Ramírez, David, Concha, Guierdy, Arévalo, Bárbara, Prent-Peñaloza, Luis, Zúñiga, Leandro, Kiper, Aytug K, Rinné, Susanne, Reyes-Parada, Miguel, Decher, Niels, González, Wendy, Caballero, Julio

“…TASK-3 is a two-pore domain potassium (K ) channel highly expressed in the hippocampus, cerebellum, and cortex. TASK-3 has been identified as an oncogenic…”
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Understanding the Cap Structure in K2P Channels by Zúñiga, Leandro, Zúñiga, Rafael

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The Insensitivity of TASK-3 K₂P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure by Concha, Guierdy, Bustos, Daniel, Zúñiga, Rafael, Catalán, Marcelo A, Zúñiga, Leandro

“…Two-pore domain K⁺ channels (K₂P) display a characteristic extracellular cap structure formed by two M1-P1 linkers, the functional role of which is poorly…”
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An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K2P K+ Channel by Extracellular pH[S] by González, Wendy, Zúñiga, Leandro, Cid, L. Pablo, Arévalo, Barbara, Niemeyer, María Isabel, Sepúlveda, Francisco V.

“…Proton-gated TASK-3 K+ channel belongs to the K2P family of proteins that underlie the K+ leak setting the membrane potential in all cells. TASK-3 is under…”
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Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels by Bustos, Daniel, Bedoya, Mauricio, Ramírez, David, Concha, Guierdy, Zúñiga, Leandro, Decher, Niels, Hernández-Rodríguez, Erix, Sepúlveda, Francisco, Martínez, Leandro, González, Wendy

“…Two-pore domain potassium (K2P) channels maintain the cell’s background conductance by stabilizing the resting membrane potential. They assemble as dimers…”
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A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons by Zúñiga, Rafael, Mancilla, Daniel, Rojas, Tamara, Vergara, Fernando, González, Wendy, Catalán, Marcelo A., Zúñiga, Leandro

“…Two pore domain potassium channels (K2P) are strongly expressed in the nervous system (CNS), where they play a central role in excitability. These channels…”
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Correction: Concha, G., et al. The Insensitivity of TASK-3 K2P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure. Int. J. Mol. Sci. 2018, 19, 2437 by Concha, Guierdy, Bustos, Daniel, Zúñiga, Rafael, Catalán, Marcelo, Zúñiga, Leandro

“…We would like to submit the following correction to our published paper [...]…”
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Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels by Dubó, Sebastián, Gallegos, David, Cabrera, Lissette, Sobrevia, Luis, Zúñiga, Leandro, González, Marcelo

“…Impairment of insulin signaling on diabetes mellitus has been related to cardiovascular dysfunction, heart failure, and sudden death. In human endothelium,…”
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Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K⁺ channel by Niemeyer, María Isabel, González-Nilo, Fernando D, Zúñiga, Leandro, González, Wendy, Cid, L. Pablo, Sepúlveda, Francisco V

“…Potassium channels share a common selectivity filter that determines the conduction characteristics of the pore. Diversity in K⁺ channels is given by how they…”
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