Search Results - "Zuniga, Jorge E."

Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A by Zuniga, Jorge E, Hammill, Jared T, Drory, Omri, Nuss, Jonathan E, Burnett, James C, Gussio, Rick, Wipf, Peter, Bavari, Sina, Brunger, Axel T

“…The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of…”
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A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate by Zuniga, Jorge E., Schmidt, James J., Fenn, Timothy, Burnett, James C., Araç, Demet, Gussio, Rick, Stafford, Robert G., Badie, Shirin S., Bavari, Sina, Brunger, Axel T.

“…Botulinum neurotoxin serotype A is the most lethal of all known toxins. Here, we report the crystal structure, along with SAR data, of the zinc metalloprotease…”
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The TβR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding by Zuniga, Jorge E., Ilangovan, Udayar, Mahlawat, Pardeep, Hinck, Cynthia S., Huang, Tao, Groppe, Jay C., McEwen, Donald G., Hinck, Andrew P.

“…Transforming growth factor β isoforms (TGF-β) are among the most recently evolved members of a signaling superfamily with more than 30 members. TGF-β play…”
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Binding properties and solution structure of the TGF-β type I receptor extracellular domain by Zuniga, Jorge E

“…The TGF-β superfamily is a group of polypeptides that regulate various cell responses in metazoans, including cell growth, differentiation, apoptosis, and…”
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Assembly of TβRI:TβRII:TGFβ Ternary Complex in vitro with Receptor Extracellular Domains is Cooperative and Isoform-dependent by Zúñiga, Jorge E., Groppe, Jay C., Cui, Yumin, Hinck, Cynthia S., Contreras-Shannon, Verónica, Pakhomova, Olga N., Yang, Junhua, Tang, Yuping, Mendoza, Valentín, López-Casillas, Fernando, Sun, LuZhe, Hinck, Andrew P.

“…Transforming growth factor-β (TGFβ) isoforms initiate signaling by assembling a heterotetrameric complex of paired type I (TβRI) and type II (TβRII) receptors…”
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Assembly of TbetaRI:TbetaRII:TGFbeta ternary complex in vitro with receptor extracellular domains is cooperative and isoform-dependent by Zúñiga, Jorge E, Groppe, Jay C, Cui, Yumin, Hinck, Cynthia S, Contreras-Shannon, Verónica, Pakhomova, Olga N, Yang, Junhua, Tang, Yuping, Mendoza, Valentín, López-Casillas, Fernando, Sun, LuZhe, Hinck, Andrew P

“…Transforming growth factor-beta (TGFbeta) isoforms initiate signaling by assembling a heterotetrameric complex of paired type I (TbetaRI) and type II…”
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Measurements of Concentration Fluctuations in Gaseous Mixtures by Edwards, William M, Zuniga-Chaves, Jorge E, Worley, Frank L, Luss, Dan

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