Search Results - "Zuniga, Edison S."

The future for early-stage tuberculosis drug discovery by Zuniga, Edison S, Early, Julie, Parish, Tanya

“…There is an urgent need for new and better drugs to treat tuberculosis due to lengthy and complex treatment regimens and a rising problem of drug resistance…”
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Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents by Kesicki, Edward A, Bailey, Mai A, Ovechkina, Yulia, Early, Julie V, Alling, Torey, Bowman, Julie, Zuniga, Edison S, Dalai, Suryakanta, Kumar, Naresh, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua O, Parish, Tanya

“…The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity…”
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Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis by Wescott, Heather H, Zuniga, Edison S, Bajpai, Anumita, Trujillo, Carolina, Ehrt, Sabine, Schnappinger, Dirk, Roberts, David M, Parish, Tanya

“…Tuberculosis is a massive global burden and is increasingly resistant to first- and second-line drugs. There is an acute need for new anti-mycobacterial drugs…”
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Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24 by Botchkina, Galina I, Zuniga, Edison S, Rowehl, Rebecca H, Park, Rosa, Bhalla, Rahuldev, Bialkowska, Agnieszka B, Johnson, Francis, Golub, Lorne M, Zhang, Yu, Ojima, Iwao, Shroyer, Kenneth R

“…Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells…”
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New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells by Botchkina, Galina I, Zuniga, Edison S, Das, Manisha, Wang, Yuan, Wang, Hichao, Zhu, Shu, Savitt, Anne G, Rowehl, Rebecca A, Leyfman, Yan, Ju, Jingfang, Shroyer, Kenneth, Ojima, Iwao

“…Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs)…”
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Design, Synthesis, and Biological Evaluation of Theranostic Vitamin–Linker–Taxoid Conjugates by Vineberg, Jacob G, Wang, Tao, Zuniga, Edison S, Ojima, Iwao

“…Novel tumor-targeting theranostic conjugates 1 and 2, bearing either a fluorine-labeled prosthetic as a potential 18F-PET radiotracer (1) or a fluorescence…”
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Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy by Vineberg, Jacob G, Zuniga, Edison S, Kamath, Anushree, Chen, Ying-Jen, Seitz, Joshua D, Ojima, Iwao

“…Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two…”
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Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase by Melief, Eduard, Bonnett, Shilah A, Zuniga, Edison S, Parish, Tanya

“…The diaminoquinazoline series has good potency against Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis…”
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The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents by Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya

“…[Display omitted] We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the…”
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Fluorine-containing taxoid anticancer agents and their tumor-targeted drug delivery by Seitz, Joshua, Vineberg, Jacob G., Zuniga, Edison S., Ojima, Iwao

“…This account presents our recent progress, in perspective, on the strategic incorporation of fluorine(s) for the development of taxoid-based tumor-targeted…”
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Tumor-targeting drug delivery of new-generation taxoids by Ojima, Iwao, Zuniga, Edison S, Berger, William T, Seitz, Joshua D

“…A long-standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug-delivery systems have been explored to…”
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Targeted and armed oncolytic adenovirus via chemoselective modification by Banerjee, Partha S., Zuniga, Edison S., Ojima, Iwao, Carrico, Isaac S.

“…Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When…”
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Design, synthesis and biological evaluation of new-generation taxoid-based tumor-targeting by Zuniga, Edison S

“…Over the past decades, chemotherapy has transitioned to an age of "targeted therapy." The development of Gleevec (Novartis) and Tarceva (Genentech and OSI…”
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