Search Results - "Zummo, Francesco P"
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Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis
Published in Nature communications (10-09-2022)“…Tissue injury triggers activation of mesenchymal lineage cells into wound-repairing myofibroblasts, whose unrestrained activity leads to fibrosis. Although…”
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O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts
Published in Cell death & disease (03-06-2024)“…Tissue injury causes activation of mesenchymal lineage cells into wound-repairing myofibroblasts (MFs), whose uncontrolled activity ultimately leads to…”
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Glucagon-Like Peptide 1 Protects Pancreatic β-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function
Published in Diabetes (New York, N.Y.) (01-05-2017)“…Studies in animal models of type 2 diabetes have shown that glucagon-like peptide 1 (GLP-1) receptor agonists prevent β-cell loss. Whether GLP-1 mediates…”
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Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis
Published in Autophagy (03-04-2022)“…Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2…”
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Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells
Published in Journal of molecular endocrinology (01-11-2019)“…Long-chain saturated fatty acids are lipotoxic to pancreatic β-cells, whereas most unsaturates are better tolerated and some may even be cytoprotective. Fatty…”
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Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability
Published in Diabetologia (01-12-2015)“…Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a double system…”
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Heterozygous inactivation of plasma membrane Ca2+-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability
Published in Diabetologia (01-12-2015)“…Aims/hypothesis Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a…”
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8
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca 2+ -PPP3/calcineurin-TFEB axis
Published in Autophagy (03-04-2022)“…Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2…”
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Journal Article -
9
Heterozygous inactivation of plasma membrane Ca^sup 2+^-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability
Published in Diabetologia (01-12-2015)“…Aims/hypothesis Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a…”
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Journal Article