3439 Prospective randomized comparison of lugolcombined upper gi videoendoscopy versus routine videoendosocpy
Background: Recent reports indicate that Lugol-combined endoscopy is very effective in detecting the presence and spread of malignant lesions of the esophagus as well as Barrett tongues and dysplasia in Barrett`s esophagus. The Aim of this randomized, prospective study was to evaluate the efficacy o...
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| Published in: | Gastrointestinal endoscopy Vol. 51; no. 4; p. AB92 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Inc
01-04-2000
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| Online Access: | Get full text |
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| Summary: | Background: Recent reports indicate that Lugol-combined endoscopy is very effective in detecting the presence and spread of malignant lesions of the esophagus as well as Barrett tongues and dysplasia in Barrett`s esophagus. The Aim of this randomized, prospective study was to evaluate the efficacy of routine Lugol-staining videoendoscopy. Methods: After written informed consent 268 patients (132 female,136 men ) were randomized either to routine upper GI endoscopy (group A) or to endoscopy plus staining with 20 ml of 2% Lugol solution (group B) via a dye spraying catheter (PW-5L-1, Olympus.Co.). In group A biopsies were performed in suspicous areas and at the esophagogastric junction. In group B biopsies were taken according to staining behavior. Exclusion criteria were coagulation disorders, esophageal varices and iodine allergy. Results: In 132 patients routine vidoeendoscopy was performed (group A), 136 patients were stained with Lugol-solution (group B). Dysplastic esophageal mucosa was detected in the same percentage (0.7%) in both groups (Table). Barrett`s eophagus was detected in 7.4% with and without staining (Table). Dyplasia or early carcinoma in Barrett`s esophagus (Table) was found in 0.7 % of patients in group A and in 4.4 % in group B (p = 0.002). Conclusion: Routine staining with Lugol significantly improves detection of premalignant or malignant lesions in Barrett`s esophagus. |
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| ISSN: | 0016-5107 1097-6779 |
| DOI: | 10.1016/S0016-5107(00)14139-2 |