Effects of preoperative dexamethasone on postoperative pain, nausea, vomiting and respiratory function in women undergoing conservative breast surgery for cancer: Results of a controlled clinical trial

The objective was to evaluate whether preoperative administration of dexamethasone improved postoperative nausea and vomiting (PONV), pain and respiratory function tests in women undergoing conservative surgery for breast cancer. This was a controlled clinical trial conducted between June 2013 and O...

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Published in:	European journal of cancer care Vol. 27; no. 1; pp. e12686 - n/a
Main Authors:	Cortés‐Flores, A.O., Jiménez‐Tornero, J., Morgan‐Villela, G., Delgado‐Gómez, M., Zuloaga‐Fernández del Valle, C. J., García‐Rentería, J., Rendón‐Félix, J., Fuentes‐Orozco, C., Macías‐Amezcua, M.D., Ambriz‐González, G., Alvarez‐Villaseñor, A.S., Urias‐Valdez, D., Chavez‐Tostado, M., Contreras‐Hernández, G. I., González‐Ojeda, A.
Format:	Journal Article
Language:	English
Published:	England Hindawi Limited 01-01-2018
Subjects:	Adenocarcinoma - surgery Adult Aged Analgesics Analgesics, Opioid - therapeutic use Antiemetics Antiemetics - therapeutic use Breast cancer Breast Neoplasms - surgery Breast surgery Cancer Cancer surgery Clinical trials Complications Dexamethasone Dexamethasone - therapeutic use Double-Blind Method Drugs Evidence-based medicine Female Forced Expiratory Volume Humans mastectomy Mastectomy, Segmental Middle Aged Morphine - therapeutic use Nausea Nursing Ondansetron - therapeutic use Pain Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - epidemiology Patients Peak Expiratory Flow Rate Postoperative Nausea and Vomiting - drug therapy Postoperative Nausea and Vomiting - epidemiology postoperative pain Postoperative period Preoperative Care - methods Respiration Disorders - epidemiology Respiration Disorders - physiopathology Respiratory function respiratory function tests Respiratory system Spirometry Steroids Surgery Vital Capacity Vomiting Womens health dexamethasone mastectomy respiratory function tests postoperative pain nausea vomiting
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Summary:	The objective was to evaluate whether preoperative administration of dexamethasone improved postoperative nausea and vomiting (PONV), pain and respiratory function tests in women undergoing conservative surgery for breast cancer. This was a controlled clinical trial conducted between June 2013 and October 2014. Eighty patients were evaluated. Patients received a preoperative dose of 8 mg of dexamethasone (n = 40) or placebo (n = 40). The data on PONV and pain intensity was obtained and forced spirometry tests were performed, 1 hr before and at 1, 6, 12 and 24 hr after surgery. Any use of additional analgesic/antiemetic drugs was recorded. Patients were followed until 30 days after surgery for any surgical or medical complications. The pain intensity was lower in the treatment group for all periods; PONV was lower at 6, 12 and 24 hr; Additional analgesics/antiemetics were required less frequently (all p < .05). Both groups exhibited a restrictive ventilatory pattern immediately after surgery, which was reversed in the following hours. However, spirometric values were higher in the dexamethasone group. There were no pulmonary or metabolic complications after surgery. Our conclusions were that dexamethasone significantly reduced the incidences of PONV, pain and improved respiratory parameters, and reduced the need for additional postoperative analgesic and antiemetic drugs.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0961-5423 1365-2354
DOI:	10.1111/ecc.12686