Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan

Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan

Celiac disease (CD) is a complicated autoimmune disease that is caused by gluten sensitivity. It was commonly believed that CD only affected white Europeans, but recent findings show that it is also prevailing in some other racial groups, like South Asians, Caucasians, Africans, and Arabs. Genetics...

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Published in:Genes Vol. 15; no. 7; p. 852
Main Authors: Zulfiqar, Sumaira, Fiaz, Amna, Khan, Waqas Ahmed, Hussain, Misbah, Ali, Ansar, Ahmed, Nadeem, Ali, Basharat, Masood, Muhammad Adnan
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-07-2024
Subjects:
Alleles
Antigens
Arthritis
Autoimmune diseases
Celiac disease
Diet
Diseases
Ethanol
Ethylenediaminetetraacetic acid
Gene polymorphism
Genes
Genetic aspects
Genetic diversity
Genetic polymorphisms
Genetic testing
Genotyping
Gluten
Immune system
India
Pakistan
Population studies
Proteins
Statistical analysis
Pakistan
India
Punjab Pakistan
gastrointestinal
rs1250552
celiac disease
ZMIZ1
LPP
rs1464510
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Summary:Celiac disease (CD) is a complicated autoimmune disease that is caused by gluten sensitivity. It was commonly believed that CD only affected white Europeans, but recent findings show that it is also prevailing in some other racial groups, like South Asians, Caucasians, Africans, and Arabs. Genetics plays a profound role in increasing the risk of developing CD. Genetic Variations in non- genes such as , , , and many more influence the risk of CD in various populations. This study aimed to explore the association between LPP rs1464510 and ZMIZ1 rs1250552 and CD in the Punjabi Pakistani population. For this, a total of 70 human subjects were selected and divided into healthy controls and patients. Genotyping was performed using an in-house-developed tetra-amplification refractory mutation system polymerase chain reaction. Statistical analysis revealed a significant association between LPP rs1464510 (χ = 4.421, = 0.035) and rs1250552 (χ2 = 3.867, = 0.049) and CD. Multinomial regression analysis showed that LPP rs1464510 A allele reduces the risk of CD by ~52% (OR 0.48, CI: 0.24-0.96, 0.037), while C allele-carrying subjects are at ~2.6 fold increased risk of CD (OR 3.65, CI: 1.25-10.63, 0.017). Similarly, the rs1250552 AG genotype significantly reduces the risk of CD by 73% (OR 0.26, CI: 0.077-0.867, = 0.028). In summary, Genetic Variations in the LPP and genes influence the risk of CD in Punjabi Pakistani subjects. LPP rs1464510 A allele and AG genotype play a protective role and reduce the risk of CD.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes15070852