Search Results - "Zukin, S R"

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome by Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., Tassone, F.

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and autism. The protein (FMRP) encoded by the fragile X mental…”
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Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats by De Butte-Smith, M, Zukin, R.S, Etgen, A.M

“…Abstract Transient global ischemia induces selective, delayed neuronal death of pyramidal neurons in the hippocampal CA1. Whereas long term treatment of…”
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Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia by Javitt, Daniel C, Zukin, Stephen R, Heresco-Levy, Uriel, Umbricht, Daniel

“…Over the last 20 years, glutamatergic models of schizophrenia have become increasingly accepted as etiopathological models of schizophrenia, based on the…”
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Chronic estradiol treatment increases CA1 cell survival but does not improve visual or spatial recognition memory after global ischemia in middle-aged female rats by De Butte-Smith, M., Gulinello, M., Zukin, R.S., Etgen, A.M.

“…Transient global ischemia induces selective, delayed neuronal death in the hippocampal CA1 and cognitive deficits. Physiological levels of 17β-estradiol…”
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Recent advances in the phencyclidine model of schizophrenia by Javitt, D C, Zukin, S R

“…Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis,…”
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Alternatively spliced isoforms of the NMDARI receptor subunit by Zukin, R.Suzanne, Bennett, Michael V.L.

“…Molecularly diverse forms of the NMDA-receptor subunit NRI are formed by alternative RNA splicing. Differential splicing of three exons generates as many as…”
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Splice Variants of the N-Methyl-D-Aspartate Receptor NR1 Identify Domains Involved in Regulation by Polyamines and Protein Kinase C by Durand, Guylaine M., Michael V. L. Bennett, Zukin, R. Suzanne

“…The N-methyl-D-aspartate (NMDA) receptor NR1 gene encodes RNA that is alternatively spliced to generate at least seven variants. The variants arise from…”
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Schizophrenia: Evidence implicating hippocampal GluN2B protein and REST epigenetics in psychosis pathophysiology by Tamminga, C.A, Zukin, R.S

“…Highlights • The hippocampus shows in vivo hyperactivity in schizophrenic psychosis. • In schizophrenia, CA3 shows synaptic strengthening, which is not present…”
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Switch in Glutamate Receptor Subunit Gene Expression in CA1 Subfield of Hippocampus Following Global Ischemia in Rats by Pellegrini-Giampietro, Domenico E., Zukin, R. Suzanne, Michael V. L. Bennett, Cho, Sunghee, Pulsinelli, William A.

“…Severe, transient global ischemia of the brain induces delayed damage to specific neuronal populations. Sustained Ca2+influx through glutamate receptor…”
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Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia by Sehara, Yoshihide, Sawicka, Kirsty, Hwang, Jee-Yeon, Latuszek-Barrantes, Adrianna, Etgen, Anne M, Zukin, R Suzanne

“…Transient global ischemia causes selective, delayed death of hippocampal CA1 pyramidal neurons in humans and animals. It is well established that estrogens…”
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Cloning of an Apparent Splice Variant of the Rat N-Methyl-D-Aspartate Receptor NMDAR1 with Altered Sensitivity to Polyamines and Activators of Protein Kinase C by Durand, Guylaine M., Gregor, Paul, Zheng, Xin, Michael V. L. Bennett, Uhl, George R., Zukin, R. Suzanne

“…Molecular cloning identified complementary DNA species, from a rat ventral midbrain library, encoding apparent splice variants of the N-methyl-D-aspartate…”
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Protein Kinase C Potentiation of N-methyl-D-aspartate Receptor Activity Is Not Mediated by Phosphorylation of N-methyl-D-aspartate Receptor Subunits by Zheng, Xin, Zhang, Ling, Wang, Alice P., Michael V. L. Bennett, Zukin, R. Suzanne

“…N-methyl-D-aspartate receptors (NMDARs) are Ca2+-permeable glutamate-gated ion channels whose physiological properties in neurons are modulated by protein…”
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Amelioration of negative symptoms in schizophrenia by glycine by Javitt, D C, Zylberman, I, Zukin, S R, Heresco-Levy, U, Lindenmayer, J P

“…Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled…”
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Neuroanatomical Patterns of the μ , δ , and κ Opioid Receptors of Rat Brain as Determined by Quantitative in vitro Autoradiography by Tempel, Ann, Zukin, R. Suzanne

“…Highly specific radioligands and quantitative autoradiography reveal strikingly different neuroanatomical patterns for the μ , δ , and κ opioid receptors of…”
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Electrical Coupling and Neuronal Synchronization in the Mammalian Brain by Bennett, Michael V.L, Zukin, R.Suzanne

“…Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently,…”
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Differential Expression of Three Glutamate Receptor Genes in Developing Rat Brain: An in situ Hybridization Study by Pellegrini-Giampietro, Domenico E., Michael V. L. Bennett, Zukin, R. Suzanne

“…Non-N-methyl-D-aspartate glutamate receptors (GluRs) are encoded by a gene family, known members of which are designated GluR-1, -2, -3, -4, and -5. The…”
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Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study by Friedman, LK, Pellegrini-Giampietro, DE, Sperber, EF, Bennett, MV, Moshe, SL, Zukin, RS

“…In adult rats, intraperitoneal administration of kainic acid, a glutamic acid analog and potent neurotoxin, induces persistent seizure activity that results in…”
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Developmental regulation and cell-specific expression of N-methyl- d-aspartate receptor splice variants in rat hippocampus by Paupard, M.-C, Friedman, L.K, Zukin, R.S

“…The present study demonstrates cell-specific and developmental regulation of 5′ and 3′ splicing of the N-methyl- d-aspartate receptor NR1 subunit within…”
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Maturation and segregation of brain networks that modify seizures by Moshé, S L, Brown, L L, Kubová, H, Velísková, J, Zukin, R S, Sperber, E F

“…The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically…”
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NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity by Carroll, Reed C., Zukin, R.Suzanne

“…Dynamic regulation of synaptic efficacy is thought to play a crucial role in formation of neuronal connections and in experience-dependent modification of…”
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