Search Results - "Zugaza, J"

P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease by Kumarasinghe, L., Garcia-Gimeno, M.A., Ramirez, J., Mayor, U., Zugaza, J.L., Sanz, P.

“…Laforin and Malin are two proteins that are encoded by the genes EPM2A and EPM2B, respectively. Laforin is a glucan phosphatase and Malin is an E3-ubiquitin…”
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Protein kinase D (PKD) activation in intact cells through a protein kinase C‐dependent signal transduction pathway by Zugaza, J. L, Sinnett‐Smith, J, Van Lint, J, Rozengurt, E

“…Protein kinase D (PKD) is a serine/threonine protein kinase that is directly stimulated in vitro by phorbol esters and diacylglycerol in the presence of…”
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1–42 β-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death by Manterola, L, Hernando-Rodríguez, M, Ruiz, A, Apraiz, A, Arrizabalaga, O, Vellón, L, Alberdi, E, Cavaliere, F, Lacerda, H M, Jimenez, S, Parada, L A, Matute, C, Zugaza, J L

“…1–42 β-Amyloid (Aβ 1–42 ) peptide is a key molecule involved in the development of Alzheimer’s disease. Some of its effects are manifested at the neuronal…”
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Exchange Factors of the RasGRP Family Mediate Ras Activation in the Golgi by Caloca, María J., Zugaza, José L., Bustelo, Xosé R.

“…H-Ras and N-Ras become activated both at the plasma membrane and in endomembrane structures such as the Golgi apparatus. This compartmentalized activation is…”
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IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes by WERY-ZENNARO, S, ZUGAZA, J. L, LETOURNEUR, M, BERTOGLIO, J, PIERRE, J

“…The stress-activated pathways leading to activation of p38 MAP kinase (p38 MAPK) and c-jun N-terminal kinases (JNK) have been shown to be activated by…”
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The interaction between Cdc42 and WASP is required for SDF-1–induced T-lymphocyte chemotaxis by Haddad, Elie, Zugaza, José L., Louache, Fawzia, Debili, Najet, Crouin, Catherine, Schwarz, Klaus, Fischer, Alain, Vainchenker, William, Bertoglio, Jacques

“…In studies aimed at further characterizing the cellular immunodeficiency of the Wiskott-Aldrich syndrome (WAS), we found that T lymphocytes from WAS patients…”
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The Human Serotonin 5-HT4 Receptor Regulates Secretion of Non-amyloidogenic Precursor Protein by Robert, S J, Zugaza, J L, Fischmeister, R, Gardier, A M, Lezoualc'h, F

“…The serotonin 5-HT 4 receptor has recently gained a lot of attention for its functional roles in central processes such as memory and cognition. In this study,…”
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Structural Determinants for the Biological Activity of Vav Proteins by Zugaza, José L, López-Lago, Miguel A, Caloca, María J, Dosil, Mercedes, Movilla, Nieves, Bustelo, Xosé R

“…We have used an extensive mutagenesis approach to study the specific role of the eight structural domains of Vav during both the activation and signaling steps…”
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Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1 by Caloca, María J., Zugaza, José L., Matallanas, David, Crespo, Piero, Bustelo, Xosé R.

“…Here we describe a new signaling cross‐talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor…”
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Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway by Zugaza, José L., Waldron, Richard T., Sinnett-Smith, James, Rozengurt, Enrique

“…Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by phorbol esters via protein kinase C in intact cells. To assess the…”
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Inverted signaling hierarchy between RAS and RAC in T-lymphocytes by ZUGAZA, José L, CALOCA, Maria J, BUSTELO, Xosé R

“…In order to generate coherent biological responses to extracellular stimuli, cells have established synergistic and antagonistic crosstalk between pathways…”
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F-actin-dependent Translocation of the Rap1 GDP/GTP Exchange Factor RasGRP2 by Caloca, Mariía J, Zugaza, José L, Vicente-Manzanares, Miguel, Sánchez-Madrid, Francisco, Bustelo, Xosé R

“…RasGRPs constitute a new group of diacylglycerol-dependent GDP/GTP exchange factors that activate Ras subfamily GTPases. Despite a common structure, Ras-GRPs…”
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Involvement of Small GTPases in Mycoplasma fermentans Membrane Lipoproteins-mediated Activation of Macrophages by Rawadi, Georges, Zugaza, Jose-Luis, Lemercier, Brigitte, Marvaud, Jean Christophe, Popoff, Michel, Bertoglio, Jacques, Roman-Roman, Sergio

“…Mycoplasma fermentans lipoproteins (LAMPf) are capable of activating macrophages and inducing the secretion of proinflammatory cytokines. We have recently…”
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Protein kinase D: a novel target for diacylglycerol and phorbol esters by Rozengurt, E, Sinnett-Smith, J, Zugaza, J L

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cis-unsaturated free fatty acids block growth hormone and prolactin secretion in thyrotropin-releasing hormone-stimulated GH3 cells by perturbing the function of plasma membrane integral proteins by PEREZ, F. R, CASABIELL, X, CAMINA, J. P, ZUGAZA, J. L, CASANUEVAZ, F. F

“…In vivo FFA block basal and stimulated GH secretion and have been implicated in the pathogenesis of the altered GH secretion present in obesity and Cushing's…”
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McARDLE DISEASE by Quinlivan, R., Pietrusz, A., Pizzamiglio, C., Pattni, J., Mahroo, O., Khan, K., Elliott, P., Patasin, M., Chatfield, S., Lucia, A., Zugaza, J., Llavero, F., Godfrey, R.

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McARDLE DISEASE: P.115 Natural history of McArdle disease in a cohort of 220 patients by Quinlivan, R., Pietrusz, A., Pizzamiglio, C., Pattni, J., Mahroo, O., Khan, K., Elliott, P., Patasin, M., Chatfield, S., Lucia, A., Zugaza, J., Llavero, F., Godfrey, R.

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DOP60 Prevalence of undiagnosed inflammatory Bowel Disease in patients with spondyloarthritis: EISER Study by Gutiérrez Casbas, A, Rodríguez-Lago, I, Marín-Jiménez, I, Plaza, Z, Gratacós, J, Trujillo, E, Pérez-Pampín, E, Barreiro de Acosta, M, Aznar-Esquivel, A, Carrillo, M, García-Vivar, M L, Muñoz-Villafranca, M D C, Ladehesa, L, Iglesias-Flores, E, Merino, C, González-Lama, Y, Arévalo, M, Calvet, X, Brandy-García, A, Izquierdo-Romero, M, Manrique, S, Olmedo, R, García-LLorente, J F, Zugaza, J, Ros-Vilamajo, I, Rull, N, Pinto-Tasende, J A, Ucha, P, González, C, Rodríguez-Martín, F, Serrano, S, Domínguez-Alvaro, M, Prado-Galbarro, F J, Sanz, J

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P.124Is the expression of muscle glycogen phosphorylase tissue-specific? New perspectives on McArdle disease by Francisco Llavero Bernal, F., Alazne Arrazola Sastre, A., Miriam Luque Montoro, M., Renata Scalco, R., Chiara Pizzamiglio, C., Jatin Pattni, J., Sherryl Chatfield, S., Ros Quinlivan, R., Miguel A. Martin, M., Joaquín Arenas, J., Alejandro Lucia, A., José L. Zugaza, J.

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Partial characterization of a novel oestrogen-induced protein in the rat adenohypophysis by Casabiell, X, Zugaza, J L, Pombo, C M, Bokser, L, Mulet, N, Casanueva, F F

“…In order to detect putative markers of prolactin-secreting pituitary tumours, adult rats were subjected to long-term oestrogenization with oestradiol benzoate…”
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