Search Results - "Zueva, Irina V"

Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry by Zueva, Irina V, Lushchekina, Sofya V, Daudé, David, Chabrière, Eric, Masson, Patrick

“…Enzyme-catalyzed hydrolysis of echothiophate, a P-S bonded organophosphorus (OP) model, was spectrofluorimetrically monitored, using Calbiochem Probe IV as the…”
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Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease by Semenov, Vyacheslav E, Zueva, Irina V, Lushchekina, Sofya V, Suleimanov, Eduard G, Gubaidullina, Liliya M, Shulaeva, Marina M, Lenina, Oksana A, Petrov, Konstantin A

“…Novel derivatives based on 6-methyluracil and condensed uracil, 2,4-quinazoline-2,4-dione, were synthesized with terminal - and -benzoate moieties in…”
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Can Activation of Acetylcholinesterase by β-Amyloid Peptide Decrease the Effectiveness of Cholinesterase Inhibitors? by Zueva, Irina V, Vasilieva, Elmira A, Gaynanova, Gulnara A, Moiseenko, Andrey V, Burtseva, Anna D, Boyko, Konstantin M, Zakharova, Lucia Ya, Petrov, Konstantin A

“…A central event in the pathogenesis of Alzheimer’s disease (AD) is the accumulation of senile plaques composed of aggregated amyloid-β (Aβ) peptides. The main…”
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Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment by Kharlamova, Alexandra D, Lushchekina, Sofya V, Petrov, Konstantin A, Kots, Ekaterina D, Nachon, Florian, Villard-Wandhammer, Marielle, Zueva, Irina V, Krejci, Eric, Reznik, Vladimir S, Zobov, Vladimir V, Nikolsky, Evgeny E, Masson, Patrick

“…Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for…”
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Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease by Semenov, Vyacheslav E, Zueva, Irina V, Mukhamedyarov, Marat A, Lushchekina, Sofya V, Petukhova, Elena O, Gubaidullina, Lilya M, Krylova, Evgeniya S, Saifina, Lilya F, Lenina, Oksana A, Petrov, Konstantin A

“…In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(…”
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Synthesis and Cholinesterase Inhibitory Potency of 2,3-Indolo-oleanolic Acid and Some Related Derivatives by Petrova, Anastasiya V, Zueva, Irina V, Petrov, Konstantin A

“…In this study, the synthesis and biological activities of previously and newly synthesized oleanolic acid derivatives containing seven-membered cyclic amines…”
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Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning by Kuznetsova, Darya A, Gaynanova, Gulnara A, Vasilieva, Elmira A, Pavlov, Rais V, Zueva, Irina V, Babaev, Vasily M, Kuznetsov, Denis M, Voloshina, Alexandra D, Petrov, Konstantin A, Zakharova, Lucia Y, Sinyashin, Oleg G

“…One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing…”
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Therapy of Organophosphate Poisoning via Intranasal Administration of 2-PAM-Loaded Chitosomes by Vasilieva, Elmira A, Kuznetsova, Darya A, Valeeva, Farida G, Kuznetsov, Denis M, Zakharov, Andrey V, Amerhanova, Syumbelya K, Voloshina, Alexandra D, Zueva, Irina V, Petrov, Konstantin A, Zakharova, Lucia Ya

“…Chitosan-decorated liposomes were proposed for the first time for the intranasal delivery of acetylcholinesterase (AChE) reactivator pralidoxime chloride…”
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1-(3- Tert -Butylphenyl)-2,2,2-Trifluoroethanone as a Potent Transition-State Analogue Slow-Binding Inhibitor of Human Acetylcholinesterase: Kinetic, MD and QM/MM Studies by Zueva, Irina V, Lushchekina, Sofya V, Pottie, Ian R, Darvesh, Sultan, Masson, Patrick

“…Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative,…”
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Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model by Pashirova, Tatiana N., Zueva, Irina V., Petrov, Konstantin A., Lukashenko, Svetlana S., Nizameev, Irek R., Kulik, Natalya V., Voloshina, Aleksandra D., Almasy, Laszlo, Kadirov, Marsil K., Masson, Patrick, Souto, Eliana B., Zakharova, Lucia Ya, Sinyashin, Oleg G.

“…[Display omitted] •Solubilization, antimicrobial properties, hemolytic activity of DHDHAB are displayed.•Mixed cationic liposomes overcome the BBB via the…”
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Biomedical potentialities of cationic geminis as modulating agents of liposome in drug delivery across biological barriers and cellular uptake by Pavlov, Rais V., Gaynanova, Gulnara A., Kuznetsova, Darya A., Vasileva, Leysan A., Zueva, Irina V., Sapunova, Anastasiia S., Buzyurova, Daina N., Babaev, Vasily M., Voloshina, Alexandra D., Lukashenko, Svetlana S., Rizvanov, Ildar Kh, Petrov, Konstantin A., Zakharova, Lucia Ya, Sinyashin, Oleg G.

“…[Display omitted] •A low-toxicity positively charged liposomal nanocarrier was obtained.•The positive charge enhances long-term stability of liposomes.•In…”
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Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning by Lenina, Oksana A., Zueva, Irina V., Zobov, Vladimir V., Semenov, Vyacheslav E., Masson, Patrick, Petrov, Konstantin A.

“…Organophosphorus (OP) compounds represent a serious health hazard worldwide. The dominant mechanism of their action results from covalent inhibition of…”
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A new sensitive spectrofluorimetric method for measurement of activity and kinetic study of cholinesterases by Mukhametgalieva, Aliya R., Zueva, Irina V., Aglyamova, Aliya R., Lushchekina, Sofya V., Masson, Patrick

“…A new spectrofluorimetric method more sensitive than the Ellman method was developed for determination of both acetylcholinesterase and butyrylcholinesterase…”
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Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat by Buzyurova, Daina N., Pashirova, Tatiana N., Zueva, Irina V., Burilova, Evgenia A., Shaihutdinova, Zukhra M., Rizvanov, Ildar Kh, Babaev, Vasily M., Petrov, Konstantin A., Souto, Eliana B.

“…[Display omitted] •PEG-lipid as a modifier improved in vitro stability of solid lipid nanoparticles.•2-PAM encapsulated into PEGylated SLNs crosses the…”
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Nanoparticle-Delivered 2‑PAM for Rat Brain Protection against Paraoxon Central Toxicity by Pashirova, Tatiana N, Zueva, Irina V, Petrov, Konstantin A, Babaev, Vasily M, Lukashenko, Svetlana S, Rizvanov, Ildar Kh, Souto, Eliana B, Nikolsky, Evgeny E, Zakharova, Lucia Ya, Masson, Patrick, Sinyashin, Oleg G

“…Solid lipid nanoparticles (SLNs) are among the most promising nanocarriers to target the blood–brain barrier (BBB) for drug delivery to the central nervous…”
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Novel slow-binding reversible acetylcholinesterase inhibitors based on uracil moieties for possible treatment of myasthenia gravis and protection from organophosphate poisoning by Saifina, Liliya F., Abdalla, Mohnad, Gubaidullina, Liliya M., Zueva, Irina V., Eltayb, Wafa Ali, El-Arabey, Amr Ahmed, Kharlamova, Alexandra D., Lenina, Oksana A., Semenov, Vyacheslav E., Petrov, Konstantin A.

“…A series of new compounds in which uracil and 3,6-dimethyluracil moieties are bridged with different spacers were prepared and evaluated in vitro for the…”
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Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase by Zueva, Irina V, Lushchekina, Sofya V, Masson, Patrick

“…The role of water in oxime-mediated reactivation of phosphylated cholinesterases (ChEs) has been asked with recurrence. To investigate oximate water structure…”
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Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer's disease via an intranasal route by Burilova, Evgenia A, Pashirova, Tatiana N, Zueva, Irina V, Gibadullina, Elmira M, Lushchekina, Sofya V, Sapunova, Anastasia S, Kayumova, Ramilya M, Rogov, Alexey M, Evtjugin, Vladimir G, Sudakov, Igor A, Vyshtakalyuk, Alexandra B, Voloshina, Alexandra D, Bukharov, Sergey V, Burilov, Alexander R, Petrov, Konstantin A, Zakharova, Lucia Ya, Sinyashin, Oleg G

“…New lipid-based nanomaterials and multi-target directed ligands (MTDLs) based on sterically hindered phenol, containing a quaternary ammonium moiety (SHP-s-R,…”
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Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection by Pashirova, Tatiana N., Braïki, Anissa, Zueva, Irina V., Petrov, Konstantin A., Babaev, Vasily M., Burilova, Evgenia A., Samarkina, Darya A., Rizvanov, Ildar Kh, Souto, Eliana B., Jean, Ludovic, Renard, Pierre-Yves, Masson, Patrick, Zakharova, Lucia Ya, Sinyashin, Oleg G.

“…A novel approach for brain protection against poisoning by organophosphorus agents is developed based on the combination treatment of dual delivery of two…”
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6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase by Semenov, Vyacheslav E., Zueva, Irina V., Lushchekina, Sofya V., Lenina, Oksana A., Gubaidullina, Lilya M., Saifina, Lilya F., Shulaeva, Marina M., Kayumova, Ramilya M., Saifina, Alina F., Gubaidullin, Aidar T., Kondrashova, Svetlana A., Latypov, Shamil K., Masson, Patrick, Petrov, Konstantin A.

“…New uncharged conjugates of 6-methyluracil derivatives with imidazole-2-aldoxime and 1,2,4-triazole-3-hydroxamic acid units were synthesized and studied as…”
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